Mouse FGF acidic/FGF1 DuoSet ELISA, 5 Plate

• Reactivity: Mu
• Applications: ELISA
• Conjugate: Biotin

Mouse FGF acidic/FGF1 DuoSet ELISA, 5 Plate Summary

• Source: N/A
• Assay Type: Solid Phase Sandwich ELISA
• Inter-Assay: See PDF Datasheet for details
• Intra-Assay: See PDF Datasheet for details
• Spike Recovery: See PDF Datasheet for details
• Sample Volume: See PDF Datasheet for details
• Gene: Fgf1

Applications/Dilutions

• Dilutions:
  • ELISA
• Application Notes: No significant interference observed with available related molecules.

Packaging, Storage & Formulations

• Storage: Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Mouse FGF acidic/FGF1 DuoSet ELISA, 5 Plate

• AFGF
• alpha
• alpha-ECGF
• beta-ECGF
• ECGF
• ECGFB
• ECGF-betaAcidic fibroblast growth factor
• endothelial cell growth factor, beta
• FGF acidic
• FGF-1
• FGFABeta-endothelial cell growth factor
• FGF-alpha
• fibroblast growth factor 1 (acidic)
• GLIO703
• HBGF1
• HBGF-1
• heparin-binding growth factor 1

Background

FGF acidic, also known as FGF-1, ECGF, and HBGF-1, is a secreted mitogen that stimulates the proliferation of all cells of mesodermal origin and many cells of neuroectodermal, ectodermal, and endodermal origin. It plays a number of roles in development, regeneration, and angiogenesis. FGF acidic is released extracellularly as a disulfide-linked homodimer and is stored in complex with extracellular heparan sulfate. The association of FGF acidic with heparan sulfate is a prerequisite for its subsequent interaction with FGF receptors. Internalized FGF acidic can translocate to the cytosol and to the nucleus. Intracellular FGF acidic functions as a survival factor by inhibiting p53 activity and proapoptotic signaling.

Publications for FGF acidic/FGF1 (DY4686-05)(3)

Publications using DY4686-05

• Xu, Y;Alves-Wagner, AB;Inada, H;Firouzjah, SD;Osana, S;Amir, MS;Conlin, RH;Hirshman, MF;Nozik, ES;Goodyear, LJ;Nagatomi, R;Kusuyama, J; Placenta-derived SOD3 deletion impairs maternal behavior via alterations in FGF/FGFR-prolactin signaling axis Cell reports 2024-09-25 [PMID: 39325622] (Mouse)
• Luis, TC;Barkas, N;Carrelha, J;Giustacchini, A;Mazzi, S;Norfo, R;Wu, B;Aliouat, A;Guerrero, JA;Rodriguez-Meira, A;Bouriez-Jones, T;Macaulay, IC;Jasztal, M;Zhu, G;Ni, H;Robson, MJ;Blakely, RD;Mead, AJ;Nerlov, C;Ghevaert, C;Jacobsen, SEW; Perivascular niche cells sense thrombocytopenia and activate hematopoietic stem cells in an IL-1 dependent manner Nature communications 2023-09-28 [PMID: 37770432] (Mouse)
• P Podkalicka, O Mucha, I Bronisz-Bu, M Kozakowska, K Pietraszek, A Cetnarowsk, U G?owniak-K, K Bukowska-S, M Cie?la, M Kulecka, J Ostrowski, M Miku?a, A Potulska-C, A Kostera-Pr, A Józkowicz, A ?oboda, J Dulak Lack of miR-378 attenuates muscular dystrophy in mdx mice JCI Insight, 2020-06-04;5(11):. 2020-06-04 [PMID: 32493839] (Transgenic Mouse)

FAQs for FGF acidic/FGF1 (DY4686-05). (Showing 1 - 1 of 1 FAQs).

1. What is the difference between the Quantikine and Duoset ELISA kits?
   • Our Quantikine kits are fully optimized and validated for the sample types listed on the product specific webpage and datasheet, as this can vary between kits. Each kit is supplied ready to use with one pre-coated 96-well plate, a detection antibody directly conjugated to HRP, and all other necessary reagents. These kits are ideal for researchers who want the convenience of a ready to use and optimized ELISA product. Some of these kits are also available prepackaged in larger 6 and 50 plate sizes.Our DuoSet Kits, in contrast, are ELISA development kits containing the capture and detection antibody, the mass-value calibrated standard, and streptavidin-HRP to prepare approximately 5 or 15 plates. Ancillary reagents will need to be used/purchased, and for most kits, we will recommend one of our Ancillary Reagent Kits, which contain the reagents we use ourselves in-house. DuoSet kits are validated only for cell culture supernatant samples and therefore require further development and validation for accurate measurement in more complex samples such as serum and plasma. Our DuoSet Kits offer an economical, flexible alternative for the experienced ELISA user.

Bioinformatics

• Gene Symbol: Fgf1