Mouse CXCL2/MIP-2 DuoSet ELISA, 15 Plate

• Reactivity: Mu
• Applications: ELISA
• Conjugate: Biotin

Mouse CXCL2/MIP-2 DuoSet ELISA, 15 Plate Summary

• Source: N/A
• Assay Type: Solid Phase Sandwich ELISA
• Inter-Assay: See PDF Datasheet for details
• Intra-Assay: See PDF Datasheet for details
• Spike Recovery: See PDF Datasheet for details
• Sample Volume: See PDF Datasheet for details
• Gene: Cxcl2

Applications/Dilutions

• Dilutions:
  • ELISA
• Application Notes: No significant interference observed with available related molecules.

Packaging, Storage & Formulations

• Storage: Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Mouse CXCL2/MIP-2 DuoSet ELISA, 15 Plate

• chemokine (C-X-C motif) ligand 2
• CINC-2a
• CINC3
• CINC-3
• C-X-C Motif Chemokine 2
• CXCL2
• GRO beta
• GRO2 oncogene
• GRO2
• GROB
• Gro-beta
• Growth-regulated protein beta
• Macrophage inflammatory protein 2-alpha
• melanoma growth stimulatory activity beta
• MGSA beta
• MGSA-b
• MGSA-beta
• MIP2
• MIP-2
• MIP2A
• MIP-2a
• MIP2-alpha
• SCYB2

Background

CXCL2/GRO beta, also called MIP-2 in mouse and CINC-3 in rat, is a member of the CXC chemokine family. Human CXCL2/GRO beta is 107 amino acids (aa) in length with a predicted molecular weight of 11 kDa. The mouse and rat orthologs share 70% and 71% aa sequence identity with the human protein, respectively. N-terminal aa 1-4 of CXCL2/GRO beta can be post-translationally cleaved which confers enhanced hematopoietic bioactivity. CXCL2/GRO beta is produced by a variety of cell types including monocytes and macrophages at sites of inflammation and is chemotactic for granulocytes, including neutrophils.

Publications for CXCL2/GRO beta/MIP-2/CINC-3 (DY452)(139)

Publications using DY452

• Tanino, Y;Wang, X;Nikaido, T;Sato, Y;Togawa, R;Watanabe, N;Tanino, M;Kadomatsu, K;Shibata, Y; Midkine Deficiency Attenuates Lipopolysaccharide-Induced Pulmonary Inflammation International journal of molecular sciences 2025-09-02 [PMID: 40943439] (Mouse, Transgenic Mouse)
• Brune, JE;Chang, MY;Tang, F;Lopez-Martinez, C;Reeves, SR;Chan, CK;Waldron, P;Boyd, DF;Gharib, SA;Thomas, PG;Altemeier, WA;Frevert, CW; Immunomodulation of the Innate Host Response by Mesenchymal-Derived Versican during Influenza A Virus Infection bioRxiv : the preprint server for biology 2025-08-02 [PMID: 40766376] (Mouse)
• Gong, HH;Worley, MJ;Carver, KA;Godin, CJ;Deng, JC; Deficient neutrophil responses early in influenza infection promote viral replication and pulmonary inflammation PLoS pathogens 2025-01-17 [PMID: 39823516] (Mouse)
• Hamadi, N;Al?Salam, S;Beegam, S;Zaaba, N;Elzaki, O;Nemmar, A; Chronic Exposure to Two Regimens of Waterpipe Smoke Elicits Lung Injury, Genotoxicity, and Mitochondrial Impairment with the Involvement of MAPKs Activation in Mice International journal of molecular sciences 2025-01-06 [PMID: 39796284] (Mouse)
• Kent, A;Yee Mon, KJ;Hutchins, Z;Putzel, G;Zhigarev, D;Grier, A;Jia, B;Kortlever, RM;Barbet, G;Evan, GI;Blander, JM; A stromal inflammasome Ras safeguard against Myc-driven lymphomagenesis Nature immunology 2025-01-01 [PMID: 39747433] (Mouse, Transgenic Mouse)
• Chen, K;Han, H;Zhao, S;Xu, B;Yin, B;Lawanprasert, A;Trinidad, M;Burgstone, BW;Murthy, N;Doudna, JA; Lung and liver editing by lipid nanoparticle delivery of a stable CRISPR-Cas9 ribonucleoprotein Nature biotechnology 2024-10-16 [PMID: 39415058] (Mouse)
• Diercks, AH;Podolskaia, IS;Murray, TA;Jahn, AN;Mai, D;Liu, D;Amon, LM;Nakagawa, Y;Shimano, H;Aderem, A;Gold, ES; Oxysterol binding protein regulates the resolution of TLR-induced cytokine production in macrophages Proceedings of the National Academy of Sciences of the United States of America 2024-08-13 [PMID: 39361877] (Mouse)
• Sun, L;Apweiler, M;Tirkey, A;Klett, D;Normann, C;Dietz, GPH;Lehner, MD;Fiebich, BL; Anti-Neuroinflammatory Effects of Ginkgo biloba Extract EGb 761 in LPS-Activated BV2 Microglial Cells International journal of molecular sciences 2024-07-25 [PMID: 39125680] (Mouse)
• Huang, Q;Yang, G;Tang, C;Dou, B;Hu, Y;Liu, H;Wu, X;Zhang, H;Wang, H;Xu, L;Yang, XD;Xu, Y;Zheng, Y; Rujin Jiedu decoction protects against influenza virus infection by modulating gut microbiota Heliyon 2024-07-15 [PMID: 39071618] (Mouse)
• Das, S;Kaminski, TW;Schlegel, BT;Bain, W;Hu, S;Patel, A;Kale, SL;Chen, K;Lee, JS;Mallampalli, RK;Kagan, VE;Rajasundaram, D;McVerry, BJ;Sundd, P;Kitsios, GD;Ray, A;Ray, P; Neutrophils and galectin-3 defend mice from lethal bacterial infection and humans from acute respiratory failure Nature communications 2024-06-03 [PMID: 38830855] (Mouse)
• Sun, L;Wilke Saliba, S;Apweiler, M;Akmermer, K;Herlan, C;Grathwol, C;de Oliveira, ACP;Normann, C;Jung, N;Bräse, S;Fiebich, BL; Anti-Neuroinflammatory Effects of a Macrocyclic Peptide-Peptoid Hybrid in Lipopolysaccharide-Stimulated BV2 Microglial Cells International journal of molecular sciences 2024-04-18 [PMID: 38674048] (Mouse)
• Kim, YT;Huh, JW;Choi, YH;Yoon, HK;Nguyen, TT;Chun, E;Jeong, G;Park, S;Ahn, S;Lee, WK;Noh, YW;Lee, KS;Ahn, HS;Lee, C;Lee, SM;Kim, KS;Suh, GJ;Jeon, K;Kim, S;Jin, M; Highly secreted tryptophanyl tRNA synthetase 1 as a potential theranostic target for hypercytokinemic severe sepsis EMBO molecular medicine 2024-01-01 [PMID: 38177528] (Mouse)
• Manandhar, S;Chambers, S;Miller, A;Ishii, I;Bhatia, M; Pharmacological Inhibition and Genetic Deletion of Cystathionine Gamma-Lyase in Mice Protects against Organ Injury in Sepsis: A Key Role of Adhesion Molecules on Endothelial Cells International journal of molecular sciences 2023-09-04 [PMID: 37686458] (Transgenic Mouse, Mouse)
• Bar-Oz, M;Martini, MC;Alonso, MN;Meir, M;Lore, NI;Miotto, P;Riva, C;Angala, SK;Xiao, J;Masiello, CS;Misiakou, MA;Sun, H;Moy, JK;Jackson, M;Johansen, HK;Cirillo, DM;Shell, SS;Barkan, D; The small non-coding RNA B11 regulates multiple facets of Mycobacterium abscessus virulence PLoS pathogens 2023-08-01 [PMID: 37603560] (Mouse)
• S Devi, M Indramohan, E Jäger, J Carriere, LH Chu, L de Almeida, DR Greaves, C Stehlik, A Dorfleutne CARD-only proteins regulate in�vivo inflammasome responses and ameliorate gout Cell Reports, 2023-03-16;42(3):112265. 2023-03-16 [PMID: 36930645] (Mouse)
• TTT Nguyen, YH Choi, WK Lee, Y Ji, E Chun, YH Kim, JE Lee, HS Jung, JH Suh, S Kim, M Jin Tryptophan-dependent and -independent secretions of tryptophanyl- tRNA synthetase mediate innate inflammatory responses Cell Reports, 2022-12-30;42(1):111905. 2022-12-30 [PMID: 36640342] (Mouse)
• P Selvam, CM Cheng, HU Dahms, VK Ponnusamy, YY Sun AhR Mediated Activation of Pro-Inflammatory Response of RAW 264.7 Cells Modulate the Epithelial-Mesenchymal Transition Toxics, 2022-10-27;10(11):. 2022-10-27 [PMID: 36355934] (Mouse)
• J Yang, L Jin, HS Kim, F Tian, Z Yi, K Bedi, M Ljungman, M Pasca di M, H Crawford, J Shi KDM6A Loss Recruits Tumor-Associated Neutrophils and Promotes Neutrophil Extracellular Trap Formation in Pancreatic Cancer Cancer Research, 2022-11-15;0(0):OF1-OF14. 2022-11-15 [PMID: 36306422] (Mouse)
• AE Pottash, D Levy, A Jeyaram, L Kuo, SM Kronstadt, W Chao, SM Jay Combinatorial microRNA Loading into Extracellular Vesicles for Increased Anti-Inflammatory Efficacy Non-coding RNA, 2022-10-21;8(5):. 2022-10-21 [PMID: 36287123] (Mouse)
• PHF Sucupira, TR Moura, ILS Gurgel, TTP Pereira, ACB Padovan, MM Teixeira, D Bahia, FM Soriani In vitro and in vivo Characterization of Host-Pathogen Interactions of the L3881 Candida albicans Clinical Isolate Frontiers in Microbiology, 2022-07-11;13(0):901442. 2022-07-11 [PMID: 35898912] (Mouse)
• Xintong Dong, Nathachit Limjunyawong, Elizabeth I. Sypek, Gaofeng Wang, Roger V. Ortines, Christine Youn et al. Keratinocyte-derived defensins activate neutrophil-specific receptors Mrgpra2a/b to prevent skin dysbiosis and bacterial infection Immunity 2022-09-01 [PMID: 35882236] (Mouse)
• HOJ Morad, S Luqman, LG Pinto, KP Cunningham, B Vilar, G Clayton, M Shankar-Ha, PA McNaughton Artemisinin inhibits neutrophil and macrophage chemotaxis, cytokine production and NET release Scientific Reports, 2022-06-30;12(1):11078. 2022-06-30 [PMID: 35773325] (Mouse)
• D Boff, RC Russo, H Crijns, VLS de Oliveir, MS Mattos, PE Marques, GB Menezes, AT Vieira, MM Teixeira, P Proost, FA Amaral The Therapeutic Treatment with the GAG-Binding Chemokine Fragment CXCL9(74-103) Attenuates Neutrophilic Inflammation and Lung Dysfunction during Klebsiella pneumoniae Infection in Mice International Journal of Molecular Sciences, 2022-06-02;23(11):. 2022-06-02 [PMID: 35682923] (Mouse)
• JW Kwon, H Quan, J Song, H Chung, D Jung, JJ Hong, YR Na, SH Seok Liposomal Dexamethasone Reduces A/H1N1 Influenza-Associated Morbidity in Mice Frontiers in Microbiology, 2022-04-12;13(0):845795. 2022-04-12 [PMID: 35495698] (Mouse)
• R Giri, EC Hoedt, S Khushi, AA Salim, AS Bergot, V Schreiber, R Thomas, MA McGuckin, TH Florin, M Morrison, RJ Capon, P Ó Cuív, J Begun Secreted NF-kappaB suppressive microbial metabolites modulate gut inflammation Cell Reports, 2022-04-12;39(2):110646. 2022-04-12 [PMID: 35417687] (Mouse)
• A Moshensky, CS Brand, H Alhaddad, J Shin, JA Masso-Silv, I Advani, D Gunge, A Sharma, S Mehta, A Jahan, S Nilaad, J Olay, W Gu, T Simonson, D Almarghala, J Pham, S Perera, K Park, R Al-Kolla, H Moon, S Das, M Byun, Z Shah, Y Sari, J Heller Bro, LE Crotty Ale Effects of mango and mint pod-based e-cigarette aerosol inhalation on inflammatory states of the brain, lung, heart, and colon in mice Elife, 2022-04-12;11(0):. 2022-04-12 [PMID: 35411847] (Mouse)
• KC Ngamsri, A Fuhr, K Schindler, M Simelitidi, M Hagen, Y Zhang, J Gamper-Tsi, FM Konrad Sevoflurane Dampens Acute Pulmonary Inflammation via the Adenosine Receptor A2B and Heme Oxygenase-1 Cells, 2022-03-24;11(7):. 2022-03-24 [PMID: 35406657] (Mouse)
• P Gao, H Liu, H Huang, Y Sun, B Jia, B Hou, X Zhou, W Strober, F Zhang The Crohn Disease-associated ATG16L1T300A polymorphism regulates inflammatory responses by modulating TLR- and NLR-mediated signaling Autophagy, 2022-02-27;0(0):1-15. 2022-02-27 [PMID: 35220902] (Human)
• HI Warheit-Ni, SJ Edwards, S SenGupta, CA Parent, X Zhou, DN O'Dwyer, BB Moore Fibrotic lung disease inhibits innate immune responses to Staphylococcal pneumonia via impaired neutrophil and macrophage function JCI Insight, 2022-02-22;0(0):. 2022-02-22 [PMID: 34990413] (Mouse)
• KC Ngamsri, RA Putri, C Jans, K Schindler, A Fuhr, Y Zhang, J Gamper-Tsi, S Ehnert, FM Konrad CXCR4 and CXCR7 Inhibition Ameliorates the Formation of Platelet-Neutrophil Complexes and Neutrophil Extracellular Traps through Adora2b Signaling International Journal of Molecular Sciences, 2021-12-17;22(24):. 2021-12-17 [PMID: 34948374] (Mouse)
• L Zou, J He, L Gu, RA Shahror, Y Li, T Cao, S Wang, J Zhu, H Huang, F Chen, X Fan, J Wu, W Chao Brain innate immune response via miRNA-TLR7 sensing in polymicrobial sepsis Brain, Behavior, and Immunity, 2021-11-19;100(0):10-24. 2021-11-19 [PMID: 34808293] (Mouse)
• D Cela, SL Knackstedt, S Groves, CM Rice, JTW Kwon, B Mordmüller, B Amulic PAD4 controls chemoattractant production and neutrophil trafficking in malaria Journal of leukocyte biology, 2021-11-10;0(0):. 2021-11-10 [PMID: 34755385] (Mouse)
• E Zajta, K Csonka, A Tóth, L Tiszlavicz, T Németh, A Orosz, Á Novák, M Csikós, C Vágvölgyi, A Mócsai, A Gácser Signaling through Syk or CARD9 Mediates Species-Specific Anti-Candida Protection in Bone Marrow Chimeric Mice MBio, 2021-08-31;12(4):e0160821. 2021-08-31 [PMID: 34465030] (Mouse, Transgenic Mouse)
• A Doni, R Parente, I Laface, E Magrini, C Cunha, FS Colombo, JF Lacerda, A Campos, SN Mapelli, F Petroni, R Porte, T Schorn, A Inforzato, T Mercier, K Lagrou, J Maertens, JD Lambris, B Bottazzi, C Garlanda, M Botto, A Carvalho, A Mantovani Serum amyloid P component is an essential element of resistance against Aspergillus fumigatus Nature Communications, 2021-06-18;12(1):3739. 2021-06-18 [PMID: 34145258] (Mouse)
• MTP de Oliveir, DS Coutinho, SS Guterres, AR Pohlmann, PMRE Silva, MA Martins, A Bernardi Resveratrol-Loaded Lipid-Core Nanocapsules Modulate Acute Lung Inflammation and Oxidative Imbalance Induced by LPS in Mice Pharmaceutics, 2021-05-10;13(5):. 2021-05-10 [PMID: 34068619] (Mouse)
• P Wohlrab, M Johann Dan, W Schaubmayr, A Tiboldi, K Krenn, K Markstalle, R Ullrich, K Ulrich Kle, V Tretter Oxygen conditions oscillating between hypoxia and hyperoxia induce different effects in the pulmonary endothelium compared to constant oxygen conditions Physiological Reports, 2021-02-01;9(3):e14590. 2021-02-01 [PMID: 33565273] (Mouse)
• BA Stanfield, T Purves, S Palmer, B Sullenger, K Welty-Wolf, K Haines, S Agarwal, G Kasotakis IL-10 and class 1 histone deacetylases act synergistically and independently on the secretion of proinflammatory mediators in alveolar macrophages PLoS ONE, 2021-01-20;16(1):e0245169. 2021-01-20 [PMID: 33471802] (Mouse)
• JM Kline, E Arriaga-Go, T Yangdon, B Boo, J Landry, M Saldías-Mo, N Neamonitak, H Mengistu, S Silverio, H Zacheis, D Pasha, T Martinov, BT Fife, D Chatterjea Repeated dermal application of the common preservative methylisothiazolinone triggers local inflammation, T cell influx, and prolonged mast cell-dependent tactile sensitivity in mice PLoS ONE, 2020-10-26;15(10):e0241218. 2020-10-26 [PMID: 33104726] (Mouse)
• L Gifre-Reno, E Ugarte-Ber, E Martens, L Boon, O Cano-Garri, E Martínez-N, T Luque, R Roca-Pinil, Ò Conchillo-, N Ferrer-Mir, A Villaverde, G Opdenakker, E Garcia-Fru, A Arís Recombinant Protein-Based Nanoparticles: Elucidating their Inflammatory Effects In Vivo and their Potential as a New Therapeutic Format Pharmaceutics, 2020-05-13;12(5):. 2020-05-13 [PMID: 32414218] (Mouse)
• M Karmakar, M Minns, EN Greenberg, J Diaz-Apont, K Pestonjama, JL Johnson, JK Rathkey, DW Abbott, K Wang, F Shao, SD Catz, GR Dubyak, E Pearlman N-GSDMD trafficking to neutrophil organelles facilitates IL-1&beta release independently of plasma membrane pores and pyroptosis Nat Commun, 2020-05-05;11(1):2212. 2020-05-05 [PMID: 32371889] (Mouse)
• SH Kim, JH Hong, WK Yang, JH Geum, HR Kim, SY Choi, YM Kang, HJ An, YC Lee Herbal Combinational Medication of Glycyrrhiza glabra, Agastache rugosa Containing Glycyrrhizic Acid, Tilianin Inhibits Neutrophilic Lung Inflammation by Affecting CXCL2, Interleukin-17/STAT3 Signal Pathways in a Murine Model of COPD Nutrients, 2020-03-27;12(4):. 2020-03-27 [PMID: 32230838] (Mouse)
• A Famà, A Midiri, G Mancuso, C Biondo, G Lentini, R Galbo, MM Giardina, GV De Gaetano, L Romeo, G Teti, C Beninati Nucleic Acid-Sensing Toll-Like Receptors Play a Dominant Role in Innate Immune Recognition of Pneumococci MBio, 2020-03-24;11(2):. 2020-03-24 [PMID: 32209688] (Mouse)
• CL Hsu, KD Chhiba, R Krier-Burr, S Hosakoppal, S Berdnikovs, ML Miller, PJ Bryce Allergic inflammation is initiated by IL-33-dependent crosstalk between mast cells and basophils PLoS ONE, 2020-01-15;15(1):e0226701. 2020-01-15 [PMID: 31940364] (Mouse)
• Y Ye, L Pei, C Wu, S Liu Protective Effect of Traditional Chinese Medicine Formula RP on Lung Microenvironment in Pre-Metastasis Stage of Breast Cancer Integr Cancer Ther, 2019-01-01;18(0):1534735419876. 2019-01-01 [PMID: 31517546] (Mouse)
• S Tariket, H Hamzeh-Cog, S Laradi, CA Arthaud, MA Eyraud, T Bourlet, P Berthelot, O Garraud, F Cognasse Evidence of CD40L/CD40 pathway involvement in experimental transfusion-related acute lung injury Sci Rep, 2019-08-29;9(1):12536. 2019-08-29 [PMID: 31467410] (Human)
• M Mohammad, MT Nguyen, C Engdahl, M Na, A Jarneborn, Z Hu, A Karlsson, R Pullerits, A Ali, F Götz, T Jin The YIN and YANG of lipoproteins in developing and preventing infectious arthritis by Staphylococcus aureus PLoS Pathog., 2019-06-21;15(6):e1007877. 2019-06-21 [PMID: 31226163] (Mouse)
• JL Fachi, JS Felipe, LP Pral, BK da Silva, RO Corrêa, MCP de Andrade, DM da Fonseca, PJ Basso, NOS Câmara, ÉL de Sales E, F Dos Santos, SES Guima, AM Thomas, JC Setubal, YT Magalhães, FL Forti, T Candreva, HG Rodrigues, MB de Jesus, SR Consonni, ADS Farias, P Varga-Weis, MAR Vinolo Butyrate Protects Mice from Clostridium difficile-Induced Colitis through an HIF-1-Dependent Mechanism Cell Rep, 2019-04-16;27(3):750-761.e7. 2019-04-16 [PMID: 30995474] (Mouse)
• AC Luissint, HC Williams, W Kim, S Flemming, V Azcutia, RS Hilgarth, MNO Leary, TL Denning, A Nusrat, CA Parkos Macrophage-dependent neutrophil recruitment is impaired under conditions of increased intestinal permeability in JAM-A-deficient mice Mucosal Immunol, 2019-02-11;0(0):. 2019-02-11 [PMID: 30745566] (Mouse)
• D Emal, E Rampanelli, N Claessen, FJ Bemelman, JC Leemans, S Florquin, MC Dessing Calcineurin inhibitor Tacrolimus impairs host immune response against urinary tract infection Sci Rep, 2019-01-14;9(1):106. 2019-01-14 [PMID: 30643171] (Mouse)
• U Kulkarni, RL Zemans, CA Smith, SC Wood, JC Deng, DR Goldstein Excessive neutrophil levels in the lung underlie the age-associated increase in influenza mortality Mucosal Immunol, 2019-01-07;12(2):545-554. 2019-01-07 [PMID: 30617300] (Mouse)
• P Wohlrab, L Soto-Gonza, T Benesch, MP Winter, IM Lang, K Markstalle, V Tretter, KU Klein Intermittent Hypoxia Activates Duration-Dependent Protective and Injurious Mechanisms in Mouse Lung Endothelial Cells Front Physiol, 2018-12-06;9(0):1754. 2018-12-06 [PMID: 30574096] (Mouse)
• V Ciancarell, L Lembo-Fazi, I Paciello, AK Bruno, S Jaillon, S Berardi, M Barbagallo, S Meron-Suda, D Cohen, A Molinaro, G Rossi, C Garlanda, ML Bernardini Role of a fluid-phase PRR in fighting an intracellular pathogen: PTX3 in Shigella infection PLoS Pathog., 2018-12-07;14(12):e1007469. 2018-12-07 [PMID: 30532257] (Mouse)
• T Imai, T Matsumura, S Mayer-Lamb, CA Wells, E Ishikawa, SK Butcher, TC Barnett, MJ Walker, A Imamura, H Ishida, T Ikebe, T Miyamoto, M Ato, S Ohga, B Lepenies, NM van Sorge, S Yamasaki Lipoteichoic acid anchor triggers Mincle to drive protective immunity against invasive group A Streptococcus infection Proc. Natl. Acad. Sci. U.S.A., 2018-10-23;0(0):. 2018-10-23 [PMID: 30352847] (Mouse)
• S Cicko, TC Köhler, CK Ayata, T Müller, N Ehrat, A Meyer, M Hossfeld, A Zech, F Di Virgili, M Idzko Extracellular ATP is a danger signal activating P2X7 receptor in a LPS mediated inflammation (ARDS/ALI) Oncotarget, 2018-07-17;9(55):30635-30648. 2018-07-17 [PMID: 30093975] (Mouse)
• IK Sundar, K Rashid, J Gerloff, J Rangel-Mor, D Li, I Rahman Genetic ablation of histone deacetylase 2 leads to lung cellular senescence and lymphoid follicle formation in COPD/emphysema FASEB J., 2018-04-09;0(0):fj201701518R. 2018-04-09 [PMID: 29630406] (Mouse)
• EE Hornick, B Banoth, AM Miller, ZR Zacharias, N Jain, ME Wilson, KN Gibson-Cor, KL Legge, GA Bishop, FS Sutterwala, SL Cassel Nlrp12 Mediates Adverse Neutrophil Recruitment during Influenza Virus Infection J. Immunol., 2017-12-27;0(0):. 2017-12-27 [PMID: 29282312] (Mouse)
• K Watanabe, CA Gilchrist, MJ Uddin, SL Burgess, MM Abhyankar, SN Moonah, Z Noor, JR Donowitz, BN Schneider, T Arju, E Ahmed, M Kabir, M Alam, R Haque, P Pramoonjag, B Mehrad, WA Petri Microbiome-mediated neutrophil recruitment via CXCR2 and protection from amebic colitis PLoS Pathog., 2017-08-17;13(8):e1006513. 2017-08-17 [PMID: 28817707] (Mouse)
• Y Unno, Y Sato, S Nishida, A Nakano, R Nakano, T Ubagai, Y Ono Acinetobacter baumannii Lipopolysaccharide Influences Adipokine Expression in 3T3-L1 Adipocytes Mediators Inflamm., 2017-07-05;2017(0):9039302. 2017-07-05 [PMID: 28757686] (Mouse)
• APL D'Almeida, MT Pacheco de, ÉT de Souza, D de Sá Cout, BT Ciambarell, CR Gomes, T Terroso, SS Guterres, AR Pohlmann, PM Silva, MA Martins, A Bernardi ?-bisabolol-loaded lipid-core nanocapsules reduce lipopolysaccharide-induced pulmonary inflammation in mice Int J Nanomedicine, 2017-06-19;12(0):4479-4491. 2017-06-19 [PMID: 28684908] (Mouse)
• HH Chen, H Yuan, H Cho, Y Feng, S Ngoy, AT Kumar, R Liao, W Chao, L Josephson, DE Sosnovik Theranostic Nucleic Acid Binding Nanoprobe Exerts Anti-inflammatory and Cytoprotective Effects in Ischemic Injury Theranostics, 2017-02-08;7(4):814-825. 2017-02-08 [PMID: 28382156] (Mouse)
• M Lynch, TA Walsh, I Marszalows, AE Webb, M MacAogain, TR Rogers, H Windle, D Kelleher, MJ O'Connell, CE Loscher Surface layer proteins from virulent Clostridium difficile ribotypes exhibit signatures of positive selection with consequences for innate immune response BMC Evol. Biol, 2017-03-23;17(1):90. 2017-03-23 [PMID: 28335725] (Mouse)
• Y Wang, Q Liu, D Chen, J Guan, L Ma, G Zhong, H Shu, X Wu Chlamydial Lipoproteins Stimulate Toll-Like Receptors 1/2 Mediated Inflammatory Responses through MyD88-Dependent Pathway Front Microbiol, 2017-01-26;8(0):78. 2017-01-26 [PMID: 28184217] (Human)
• SB Fleming, C McCaughan, Z Lateef, A Dunn, LM Wise, NC Real, AA Mercer Deletion of the Chemokine Binding Protein Gene from the Parapoxvirus Orf Virus Reduces Virulence and Pathogenesis in Sheep Front Microbiol, 2017-01-24;8(0):46. 2017-01-24 [PMID: 28174562] (Mouse)
• R Th„nert, O Goldmann, A Beineke, E Medina Host-inherent variability influences the transcriptional response of Staphylococcus aureus during in vivo infection Nat Commun, 2017-02-03;8(0):14268. 2017-02-03 [PMID: 28155859] (Mouse)
• The Carbohydrate Lectin Receptor, Dectin-1, Mediates Immune Response to Exserohilum rostratum Infect. Immun, 2017-02-23;0(0):. 2017-02-23 [PMID: 28031265] (Mouse)
• Anti-Inflammatory Effects of Rosiglitazone in Obesity-Impaired Wound Healing Depend on Adipocyte Differentiation PLoS ONE, 2016-12-19;11(12):e0168562. 2016-12-19 [PMID: 27992530] (Mouse)
• Xian K Zhang The Fli-1 transcription factor is a critical regulator for controlling the expression of chemokine C-X-C motif ligand 2 (CXCL2) Mol. Immunol., 2016-11-24;81(0):59-66. 2016-11-24 [PMID: 27889620] (Mouse)
• Arne Yndestad Palmitate promotes inflammatory responses and cellular senescence in cardiac fibroblasts Biochim. Biophys. Acta, 2016-11-12;0(0):. 2016-11-12 [PMID: 27845246] (Mouse)
• Joerg Mattes TRAIL signaling is pro-inflammatory and pro-viral in a murine model of rhinovirus 1B infection Am. J. Physiol. Lung Cell Mol. Physiol., 2016-11-11;0(0):ajplung.00200. 2016-11-11 [PMID: 27836899] (Mouse)
• Klebsiella pneumoniae Siderophores Induce Inflammation, Bacterial Dissemination, and HIF-1? Stabilization during Pneumonia MBio, 2016-09-13;7(5):. 2016-09-13 [PMID: 27624128] (Mouse)
• NK cells regulate CXCR2+ neutrophil recruitment during acute lung injury J Leukoc Biol, 2016-09-06;0(0):. 2016-09-06 [PMID: 27601626] (Mouse)
• Poly-N-acetyl glucosamine production by Staphylococcus epidermidis cells increases their in vivo pro-inflammatory effect Infect Immun, 2016-09-19;0(0):. 2016-09-19 [PMID: 27481237] (Mouse)
• Marieke Pingen Host Inflammatory Response to Mosquito Bites Enhances the Severity of Arbovirus Infection Immunity, 2016-06-21;44(6):1455-69. 2016-06-21 [PMID: 27332734] (Mouse)
• Kamlesh K Gupta Plasminogen activator inhibitor-1 stimulates macrophage activation through Toll-like Receptor-4 Biochem Biophys Res Commun, 2016-06-15;0(0):. 2016-06-15 [PMID: 27317488] (Mouse)
• Tatiana Paula Teixeira Ferreira, Lívia Lacerda Mariano, Roberta Ghilosso-Bortolini, Ana Carolina Santos de de Arantes, Andrey Junior Fernandes, Michelle Berni et al. Potential of PEGylated Toll-Like Receptor 7 Ligands for Controlling Inflammation and Functional Changes in Mouse Models of Asthma and Silicosis Frontiers in Immunology 2016-03-11 [PMID: 27014274] (Mouse)
• C1P Attenuates Lipopolysaccharide-Induced Acute Lung Injury by Preventing NF-?B Activation in Neutrophils J Immunol, 2016-01-22;196(5):2319-26. 2016-01-22 [PMID: 26800872] (Mouse)
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• Yoshida K, Maekawa T, Zhu Y, Renard-Guillet C, Chatton B, Inoue K, Uchiyama T, Ishibashi K, Yamada T, Ohno N, Shirahige K, Okada-Hatakeyama M, Ishii S The transcription factor ATF7 mediates lipopolysaccharide-induced epigenetic changes in macrophages involved in innate immunological memory. Nat Immunol, 2015-08-31;16(10):1034-43. 2015-08-31 [PMID: 26322480] (Mouse)
• Sundar , Isaac K, Ahmad , Tanveer, Yao , Hongwei, Hwang , Jae-woon, Gerloff , Janice, Lawrence , B Paige, Sellix , Michael, Rahman , Irfan Influenza A virus-dependent remodeling of pulmonary clock function in a mouse model of COPD. Sci Rep, 2015-04-29;4(0):9927. 2015-04-29 [PMID: 25923474] (Mouse)
• Miyake Y, Masatsugu O, Yamasaki S C-Type Lectin Receptor MCL Facilitates Mincle Expression and Signaling through Complex Formation. J Immunol, 2015-04-17;194(11):5366-74. 2015-04-17 [PMID: 25888641] (Mouse)
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• Djukic M, Sostmann N, Bertsch T, Mecke M, Nessler S, Manig A, Hanisch U, Triebel J, Bollheimer L, Sieber C, Nau R Vitamin D deficiency decreases survival of bacterial meningoencephalitis in mice. J Neuroinflammation, 2015-01-07;12(0):208. 2015-01-07 [PMID: 25563481] (Mouse)
• Bernard N, Finlay C, Tannahill G, Cassidy J, O'Neill L, Mills K A critical role for the TLR signaling adapter Mal in alveolar macrophage-mediated protection against Bordetella pertussis. Mucosal Immunol, 2014-12-17;8(5):982-92. 2014-12-17 [PMID: 25515629] (Mouse)
• Mancuso P, O Brien E, Prano J, Goel D, Aronoff D No Impairment in host defense against Streptococcus pneumoniae in obese CPEfat/fat mice. PLoS ONE, 2014-09-09;9(9):e106420. 2014-09-09 [PMID: 25203099] (Mouse)
• Ohm I, Alfsnes K, Belland Olsen M, Ranheim T, Sandanger O, Dahl T, Aukrust P, Finsen A, Yndestad A, Vinge L Toll-like receptor 9 mediated responses in cardiac fibroblasts. PLoS ONE, 2014-08-15;9(8):e104398. 2014-08-15 [PMID: 25126740] (Mouse)
• Chen , Lianyu, Qu , Chao, Chen , Hao, Xu , Litao, Qi , Qi, Luo , Jianmin, Wang , Kun, Meng , Zhiqiang, Chen , Zhen, Wang , Peng, Liu , Luming Chinese herbal medicine suppresses invasion-promoting capacity of cancer-associated fibroblasts in pancreatic cancer. PLoS ONE, 2014-04-29;9(4):e96177. 2014-04-29 [PMID: 24781445] (Human)
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• Muto , Jun, Morioka , Yasuhide, Yamasaki , Kenshi, Kim , Margaret, Garcia , Andrea, Carlin , Aaron F, Varki , Ajit, Gallo , Richard Hyaluronan digestion controls DC migration from the skin. J Clin Invest, 2014-03-01;124(3):1309-19. 2014-03-01 [PMID: 24487587] (Mouse)
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• Hansen , Michelle, Chen , Hui, Jones , Jessica, Langenbach , Shenna Y, Vlahos , Ross, Gualano , Rosa C, Morris , Margaret, Anderson , Gary P The lung inflammation and skeletal muscle wasting induced by subchronic cigarette smoke exposure are not altered by a high-fat diet in mice. PLoS ONE, 2013-11-19;8(11):e80471. 2013-11-19 [PMID: 24260397] (Mouse)
• Farina F, Sancini G, Battaglia C, Tinaglia V, Mantecca P, Camatini M, Palestini P Milano summer particulate matter (PM10) triggers lung inflammation and extra pulmonary adverse events in mice. PLoS ONE, 2013-02-25;8(2):e56636. 2013-02-25 [PMID: 23451061] (Mouse)
• Kempuraj D, Twait E, Williard D, Yuan Z, Meyerholz D, Samuel I The novel cytokine interleukin-33 activates acinar cell proinflammatory pathways and induces acute pancreatic inflammation in mice. PLoS ONE, 2013-02-13;8(2):e56866. 2013-02-13 [PMID: 23418608] (Mouse)
• Georgiev P, Belikoff B, Hatfield S, Ohta A, Sitkovsky M, Lukashev D Genetic deletion of the HIF-1alpha isoform I.1 in T cells enhances antibacterial immunity and improves survival in a murine peritonitis model. Eur J Immunol, 2013-01-31;43(3):655-66. 2013-01-31 [PMID: 23208786] (Mouse)
• Fecal lipocalin 2, a sensitive and broadly dynamic non-invasive biomarker for intestinal inflammation. PLoS ONE, 2012-09-05;7(9):e44328. 2012-09-05 [PMID: 22957064] (Mouse)
• Aziz M, Matsuda A, Yang WL, Jacob A, Wang P Milk fat globule-epidermal growth factor-factor 8 attenuates neutrophil infiltration in acute lung injury via modulation of CXCR2. J. Immunol., 2012-05-25;189(1):393-402. 2012-05-25 [PMID: 22634615] (Mouse)
• Habibzay , M, Saldana , J I, Goulding , J, Lloyd , C M, Hussell , T Altered regulation of Toll-like receptor responses impairs antibacterial immunity in the allergic lung. Mucosal Immunol, 2012-05-02;5(5):524-34. 2012-05-02 [PMID: 22549744] (Mouse)
• Chuquimia OD, Petursdottir DH, Rahman MJ, Hartl K, Singh M, Fernandez C The role of alveolar epithelial cells in initiating and shaping pulmonary immune responses: communication between innate and adaptive immune systems. PLoS ONE, 2012-02-29;7(2):e32125. 2012-02-29 [PMID: 22393384] (Mouse)
• Veliz Rodriguez T, Moalli F, Polentarutti N, Paroni M, Bonavita E, Anselmo A, Nebuloni M, Mantero S, Jaillon S, Bragonzi A, Mantovani A, Riva F, Garlanda C Role of Toll interleukin-1 receptor (IL-1R) 8, a negative regulator of IL-1R/Toll-like receptor signaling, in resistance to acute Pseudomonas aeruginosa lung infection. Infect. Immun., 2011-10-24;80(1):100-9. 2011-10-24 [PMID: 22025515] (Mouse)
• Steinwede K, Tempelhof O, Bolte K, Maus R, Bohling J, Ueberberg B, Langer F, Christman JW, Paton JC, Ask K, Maharaj S, Kolb M, Gauldie J, Welte T, Maus UA Local delivery of GM-CSF protects mice from lethal pneumococcal pneumonia. J. Immunol., 2011-10-14;187(10):5346-56. 2011-10-14 [PMID: 22003204] (Mouse)
• McMillan DH, Baglole CJ, Thatcher TH, Maggirwar S, Sime PJ, Phipps RP Lung-targeted overexpression of the NF-kappaB member RelB inhibits cigarette smoke-induced inflammation. Am. J. Pathol., 2011-05-05;179(1):125-33. 2011-05-05 [PMID: 21703398] (Mouse)
• Arndt PG, Strahan B, Wang Y, Long C, Horiuchi K, Walcheck B Leukocyte ADAM17 Regulates Acute Pulmonary Inflammation. PLoS ONE, 2011-05-16;6(5):e19938. 2011-05-16 [PMID: 21603616] (Mouse)
• Moalli F, Paroni M, Veliz Rodriguez T, Riva F, Polentarutti N, Bottazzi B, Valentino S, Mantero S, Nebuloni M, Mantovani A, Bragonzi A, Garlanda C The Therapeutic Potential of the Humoral Pattern Recognition Molecule PTX3 in Chronic Lung Infection Caused by Pseudomonas aeruginosa. J. Immunol., 2011-03-25;186(9):5425-34. 2011-03-25 [PMID: 21441447] (Mouse)
• Russo RC, Garcia CC, Barcelos LS, Rachid MA, Guabiraba R, Roffe E, Souza AL, Sousa LP, Mirolo M, Doni A, Cassali GD, Pinho V, Locati M, Teixeira MM Phosphoinositide 3-kinase gamma plays a critical role in bleomycin-induced pulmonary inflammation and fibrosis in mice. J. Leukoc. Biol., 2010-11-02;89(2):269-82. 2010-11-02 [PMID: 21048214] (Mouse)
• Van Den Boogaard FE, Brands X, Schultz MJ, Levi M, Roelofs JJ, Van 't Veer C, van der Poll T Recombinant human tissue factor pathway inhibitor exerts anticoagulant, anti-inflammatory and antimicrobial effects in murine pneumococcal pneumonia. J. Thromb. Haemost., 2011-01-01;9(1):122-32. 2011-01-01 [PMID: 21029363] (Mouse)
• Lamacchia C, Palmer G, Bischoff L, Rodriguez E, Talabot-Ayer D, Gabay C Distinct roles of hepatocyte- and myeloid cell-derived IL-1 receptor antagonist during endotoxemia and sterile inflammation in mice. J. Immunol., 2010-07-16;185(0):2516-24. 2010-07-16 [PMID: 20639493] (Mouse)
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• van Zoelen MA, Achouiti A, Schmidt AM, Yang H, Florquin S, Tracey KJ, van der Poll T Ligands of the receptor for advanced glycation end products, including high-mobility group box 1, limit bacterial dissemination during Escherichia coli peritonitis. Crit. Care Med., 2010-06-01;38(6):1414-22. 2010-06-01 [PMID: 20386310] (Mouse)
• Zhu M, Hug C, Kasahara DI Impact of adiponectin deficiency on pulmonary responses to acute ozone exposure in mice. Am. J. Respir. Cell Mol. Biol., 2009-11-13;43(4):487-97. 2009-11-13 [PMID: 19915153] (Mouse)
• Zhou H, Andonegui G, Wong CH, Kubes P Role of endothelial TLR4 for neutrophil recruitment into central nervous system microvessels in systemic inflammation. J. Immunol., 2009-09-28;183(8):5244-50. 2009-09-28 [PMID: 19786543] (Mouse)
• van der Veen BS, Petersen AH, Belperio JA, Satchell SC, Mathieson PW, Molema G, Heeringa P Spatiotemporal expression of chemokines and chemokine receptors in experimental anti-myeloperoxidase antibody-mediated glomerulonephritis. Clin. Exp. Immunol., 2009-10-01;158(1):143-53. 2009-10-01 [PMID: 19737241] (Mouse)
• Lagler H, Sharif O, Haslinger I, Matt U, Stich K, Furtner T, Doninger B, Schmid K, Gattringer R, de Vos AF, Knapp S TREM-1 activation alters the dynamics of pulmonary IRAK-M expression in vivo and improves host defense during pneumococcal pneumonia. J. Immunol., 2009-07-13;183(3):2027-36. 2009-07-13 [PMID: 19596984] (Mouse)
• Kariya S, Okano M, Fukushima K, Nomiya S, Kataoka Y, Nomiya R, Akagi H, Nishizaki K Expression of inflammatory mediators in the otitis media induced by Helicobacter pylori antigen in mice. Clin. Exp. Immunol., 2008-08-22;154(1):134-40. 2008-08-22 [PMID: 18727622] (Mouse)
• Coelho FM, Pinho V, Amaral FA, Sachs D, Costa VV, Rodrigues DH, Vieira AT, Silva TA, Souza DG, Bertini R, Teixeira AL, Teixeira MM The chemokine receptors CXCR1/CXCR2 modulate antigen-induced arthritis by regulating adhesion of neutrophils to the synovial microvasculature. Arthritis Rheum., 2008-08-01;58(8):2329-37. 2008-08-01 [PMID: 18668539] (Mouse)
• Sun J, Ramnath RD, Tamizhselvi R, Bhatia M Neurokinin A engages neurokinin-1 receptor to induce NF-kappaB-dependent gene expression in murine macrophages: implications of ERK1/2 and PI 3-kinase/Akt pathways. Am. J. Physiol., Cell Physiol., 2008-07-02;295(3):C679-91. 2008-07-02 [PMID: 18596216] (Mouse)
• Lembo A, Pelletier M, Iyer R, Timko M, Dudda JC, West TE, Wilson CB, Hajjar AM, Skerrett SJ Administration of a synthetic TLR4 agonist protects mice from pneumonic tularemia. J. Immunol., 2008-06-01;180(11):7574-81. 2008-06-01 [PMID: 18490759] (Mouse)
• Brandt EB, Mingler MK, Stevenson MD, Wang N, Khurana Hershey GK, Whitsett JA, Rothenberg ME Surfactant protein D alters allergic lung responses in mice and human subjects. J. Allergy Clin. Immunol., 2008-03-19;121(5):1140-1147.e2. 2008-03-19 [PMID: 18355911] (Mouse)
• Cardona AE, Sasse ME, Liu L, Cardona SM, Mizutani M, Savarin C, Hu T, Ransohoff RM Scavenging roles of chemokine receptors: chemokine receptor deficiency is associated with increased levels of ligand in circulation and tissues. Blood, 2008-03-17;112(2):256-63. 2008-03-17 [PMID: 18347198] (Mouse)
• Nomellini V, Faunce DE, Gomez CR, Kovacs EJ An age-associated increase in pulmonary inflammation after burn injury is abrogated by CXCR2 inhibition. J. Leukoc. Biol., 2008-03-13;83(6):1493-501. 2008-03-13 [PMID: 18319289] (Mouse)
• Cheng W, Shivshankar P, Li Z, Chen L, Yeh IT, Zhong G Caspase-1 contributes to Chlamydia trachomatis-induced upper urogenital tract inflammatory pathologies without affecting the course of infection. Infect. Immun., 2007-11-19;76(2):515-22. 2007-11-19 [PMID: 18025098] (Mouse)
• Tsuruta Y, Park YJ, Siegal GP, Liu G, Abraham E Involvement of vitronectin in lipopolysaccaride-induced acute lung injury. J. Immunol., 2007-11-15;179(10):7079-86. 2007-11-15 [PMID: 17982099] (Mouse)
• Kielian T, Esen N, Liu S, Phulwani NK, Syed MM, Phillips N, Nishina K, Cheung AL, Schwartzman JD, Ruhe JJ Minocycline modulates neuroinflammation independently of its antimicrobial activity in staphylococcus aureus-induced brain abscess. Am. J. Pathol., 2007-08-23;171(4):1199-214. 2007-08-23 [PMID: 17717149] (Mouse)
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FAQs for CXCL2/GRO beta/MIP-2/CINC-3 (DY452). (Showing 1 - 1 of 1 FAQs).

1. What is the difference between the Quantikine and Duoset ELISA kits?
   • Our Quantikine kits are fully optimized and validated for the sample types listed on the product specific webpage and datasheet, as this can vary between kits. Each kit is supplied ready to use with one pre-coated 96-well plate, a detection antibody directly conjugated to HRP, and all other necessary reagents. These kits are ideal for researchers who want the convenience of a ready to use and optimized ELISA product. Some of these kits are also available prepackaged in larger 6 and 50 plate sizes.Our DuoSet Kits, in contrast, are ELISA development kits containing the capture and detection antibody, the mass-value calibrated standard, and streptavidin-HRP to prepare approximately 5 or 15 plates. Ancillary reagents will need to be used/purchased, and for most kits, we will recommend one of our Ancillary Reagent Kits, which contain the reagents we use ourselves in-house. DuoSet kits are validated only for cell culture supernatant samples and therefore require further development and validation for accurate measurement in more complex samples such as serum and plasma. Our DuoSet Kits offer an economical, flexible alternative for the experienced ELISA user.

Bioinformatics

• Gene Symbol: Cxcl2