Mouse CCL2/JE/MCP-1 DuoSet ELISA, 15 Plate

• Reactivity: Mu
• Applications: ELISA
• Conjugate: Biotin

Mouse CCL2/JE/MCP-1 DuoSet ELISA, 15 Plate Summary

• Source: N/A
• Assay Type: Solid Phase Sandwich ELISA
• Inter-Assay: See PDF Datasheet for details
• Intra-Assay: See PDF Datasheet for details
• Spike Recovery: See PDF Datasheet for details
• Sample Volume: See PDF Datasheet for details
• Gene: Ccl2

Applications/Dilutions

• Dilutions:
  • ELISA
• Application Notes: No significant interference observed with available related molecules.

Packaging, Storage & Formulations

• Storage: Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Mouse CCL2/JE/MCP-1 DuoSet ELISA, 15 Plate

• C-C motif chemokine ligand 2
• CCL2
• GDCF-2
• HC11
• HSMCR30
• MCAF
• Mcp1
• MCP-1
• SCYA2
• SMC-CF

Background

CCL2/JE/MCP-1, is a chemokine that binds the receptor CCR2 and induces the chemoattraction of mononuclear cells. It induces the activation of monocytes, NK cells, lymphocytes, and basophils. Additionally, CCL2 promotes Th2 polarization in CD4+ T cells, and CCL2-mediated recruitment of monocytes to sites of inflammation contributes to disease severity in atherosclerosis, multiple sclerosis, and allergic asthma. Endogenous proteolytic trimming of CCL2 at the N-terminus, including the N-terminal pyrrolidone carboxylic acid-modified glutamine, downregulates activity but not receptor binding.

Publications for CCL2/JE/MCP-1 (DY479)(180)

Publications using DY479

• Feng, J;Carreño, M;Jung, H;Naidu, SD;Arroyo-Diaz, N;Ang, AD;Kulkarni, B;Kisielewski, D;Suzuki, T;Yamamoto, M;Hayes, JD;Honda, T;Leon-Ruiz, B;Eggler, AL;Vitturi, DA;Dinkova-Kostova, AT; The electrophilic metabolite of kynurenine, kynurenine-CKA, requires C151 in Keap1 to derepress Nrf2 Redox Biol 2026-01-06 [PMID: 41534303] (Mouse, Transgenic Mouse)
• Kagelmacher, M;Quella, CS;Kautz, E;Klumpp, A;Weichert, F;Zhang, I;Maysinger, D;Wedamulla, PG;Straus, SK;Risse, T;Haag, R;Pigaleva, M;Dernedde, J; Dendritic Polyglycerol Sulfate Reduces Inflammation Through Inhibition of the HMGB1/RAGE Axis in RAW 264.7 Macrophages International journal of molecular sciences 2025-10-27 [PMID: 41226481] (Mouse)
• Ganapathy, T;Yuan, J;Ho, MY;Wu, KK;Hoque, MM;Wang, B;Li, X;Wang, K;Wabitsch, M;Feng, X;Niu, Y;Long, K;Lian, Q;Zhu, Y;Cheng, KK; Adipocyte FMO3-derived TMAO induces WAT dysfunction and metabolic disorders by promoting inflammasome activation in ageing Nature communications 2025-10-06 [PMID: 41053195] (Mouse)
• Yang, J;Xu, B;Cao, J;Liu, Y;Tang, L;Zhao, P;Li, S;Li, X;Liu, J;Yu, R;Tang, Y;Tan, W;Ding, H;Li, J;Liu, Y; Characterizing the mechanisms underpinning interleukin-15R?-mediated protection against sepsis and candidiasis Cytokine 2025-09-17 [PMID: 40967153] (Mouse, Transgenic Mouse)
• Chang, KW;Chen, JT;Chuang, CN;Thi Thanh Thao, D;Huang, YT;Wu, HY;Kuo, ML;Kao, KC;Chiu, CH;Lai, CH; Microplastic exposure aggravates pneumococcus-induced inflammation in macrophages by activating ferroptosis Journal of hazardous materials 2025-08-29 [PMID: 40907312] (Mouse)
• Kumar, A;O'Brien, M;Young, VB;Yung, R; Single-cell RNA sequencing identifies accumulation of Fcgr2b+ virtual memory like CD8 T cells with cytotoxic and inflammatory potential in aged mouse white adipose tissue bioRxiv : the preprint server for biology 2025-06-30 [PMID: 40631318] (Mouse)
• Dean, LS;Wahl, M;Threatt, AN;Pauly, M;Barahona, M;Oyewole, EO;Nordgren, TM; Spectral immune cell profiling reveals modulations in immune cell response to repetitive inhaled organic dust exposure in a high omega-3 fatty acid mouse model Lipids in health and disease 2025-07-02 [PMID: 40604979] (Mouse)
• Adamowicz, K;Lima Ribeiro, AS;Golda, A;Wadowska, M;Potempa, J;Schmaderer, C;Anders, HJ;Koziel, J;Lech, M; Bidirectional Interaction Between Chronic Kidney Disease and Porphyromonas gingivalis Infection Drives Inflammation and Immune Dysfunction Journal of immunology research 2025-04-17 [PMID: 40276114] (Mouse)
• Hu, Z;Deshmukh, M;Jarneborn, A;Bollmann, M;Corciulo, C;Kopparapu, PK;Ali, A;Svensson, MND;Engdahl, C;Pullerits, R;Mohammad, M;Jin, T; Combination treatment with anti-RANKL and antibiotics for preventing joint destruction in septic arthritis JCI insight 2025-03-24 [PMID: 40067374] (Mouse)
• Faizan, MI;Kaur, G;Shaikh, SB;Effah, F;Unwalla, H;Rahman, I; Genetic diversity leads to differential inflammatory responses to cigarette smoke in mice Physiological reports 2025-01-01 [PMID: 39844449] (Mouse)
• Hamadi, N;Al?Salam, S;Beegam, S;Zaaba, N;Elzaki, O;Nemmar, A; Chronic Exposure to Two Regimens of Waterpipe Smoke Elicits Lung Injury, Genotoxicity, and Mitochondrial Impairment with the Involvement of MAPKs Activation in Mice International journal of molecular sciences 2025-01-06 [PMID: 39796284] (Mouse)
• Pinto, LG;Vilar, B;McNaughton, PA; PGE2 and HCN2 ion channels are critical mediators of pain initiated by angiotensin II Brain, behavior, and immunity 2024-12-28 [PMID: 39736364] (Mouse)
• Cheung, EC;Strathdee, D;Stevenson, D;Coomes, J;Blyth, K;Vousden, KH; Regulation of ROS signaling by TIGAR induces cancer-modulating responses in the tumor microenvironment Proceedings of the National Academy of Sciences of the United States of America 2024-12-10 [PMID: 39636862] (Mouse)
• Guo, ZF;Tongmuang, N;Li, C;Zhang, C;Hu, L;Capreri, D;Zuo, MX;Summer, R;Sun, J; Inhibiting endothelial cell Mst1 attenuates acute lung injury in mice JCI insight 2024-09-10 [PMID: 39253972] (Mouse, Transgenic Mouse)
• Nayer, B;Tan, JL;Alshoubaki, YK;Lu, YZ;Legrand, JMD;Lau, S;Hu, N;Park, AJ;Wang, XN;Amann-Zalcenstein, D;Hickey, PF;Wilson, T;Kuhn, GA;Müller, R;Vasanthakumar, A;Akira, S;Martino, MM; Local administration of regulatory T cells promotes tissue healing Nature communications 2024-09-09 [PMID: 39251592] (Mouse)
• Gabele, L;Bochow, I;Rieke, N;Sieben, C;Michaelsen-Preusse, K;Hosseini, S;Korte, M; H7N7 viral infection elicits pronounced, sex-specific neuroinflammatory responses in vitro Frontiers in cellular neuroscience 2024-08-07 [PMID: 39171200] (Mouse)
• Galley, JD;King, MK;Rajasekera, TA;Batabyal, A;Woodke, ST;Gur, TL; Gestational administration of Bifidobacterium dentium results in intergenerational modulation of inflammatory, metabolic, and social behavior Brain, behavior, and immunity 2024-08-12 [PMID: 39128569] (Mouse)
• Sun, L;Apweiler, M;Tirkey, A;Klett, D;Normann, C;Dietz, GPH;Lehner, MD;Fiebich, BL; Anti-Neuroinflammatory Effects of Ginkgo biloba Extract EGb 761 in LPS-Activated BV2 Microglial Cells International journal of molecular sciences 2024-07-25 [PMID: 39125680] (Mouse)
• Lai, HC;Chen, PH;Tang, CH;Chen, LW; IL-10 Enhances the Inhibitory Effect of Adipose-Derived Stromal Cells on Insulin Resistance/Liver Gluconeogenesis by Treg Cell Induction International journal of molecular sciences 2024-07-25 [PMID: 39125659] (Mouse)
• Huang, Q;Yang, G;Tang, C;Dou, B;Hu, Y;Liu, H;Wu, X;Zhang, H;Wang, H;Xu, L;Yang, XD;Xu, Y;Zheng, Y; Rujin Jiedu decoction protects against influenza virus infection by modulating gut microbiota Heliyon 2024-07-15 [PMID: 39071618] (Mouse)
• Sun, L;Wilke Saliba, S;Apweiler, M;Akmermer, K;Herlan, C;Grathwol, C;de Oliveira, ACP;Normann, C;Jung, N;Bräse, S;Fiebich, BL; Anti-Neuroinflammatory Effects of a Macrocyclic Peptide-Peptoid Hybrid in Lipopolysaccharide-Stimulated BV2 Microglial Cells International journal of molecular sciences 2024-04-18 [PMID: 38674048] (Mouse)
• Mingo, YB;Gabele, L;Lonnemann, N;Brône, B;Korte, M;Hosseini, S; The effects of urolithin A on poly I:C-induced microglial activation Frontiers in cellular neuroscience 2024-03-20 [PMID: 38577490] (Mouse)
• Sluiter, TJ;Tillie, RJHA;de Jong, A;de Bruijn, JBG;Peters, HAB;van de Leijgraaf, R;Halawani, R;Westmaas, M;Starink, LIW;Quax, PHA;Sluimer, JC;de Vries, MR; Myeloid PHD2 Conditional Knockout Improves Intraplaque Angiogenesis and Vascular Remodeling in a Murine Model of Venous Bypass Grafting Journal of the American Heart Association 2024-01-23 [PMID: 38258662] (Transgenic Mouse)
• Nakajima, S;Demers, G;Machuca-Parra, AI;Pour, ZD;Bairamian, D;Bouyakdan, K;Fisette, A;Kabahizi, A;Robb, J;Rodaros, D;Laurent, C;Ferreira, G;Arbour, N;Alquier, T;Fulton, S; Central activation of the fatty acid sensor GPR120 suppresses microglia reactivity and alleviates sickness- and anxiety-like behaviors Journal of neuroinflammation 2023-12-19 [PMID: 38111048] (Mouse)
• Pereira, RDD;Rabelo, RAN;Oliveira, NFM;Porto, SLT;Andrade, ACDSP;Queiroz-Junior, CM;Barbosa, CLN;de Souza-Costa, LP;Santos, FRDS;Oliveira, FBR;da Silva, BLV;Umezu, HL;Ferreira, R;da Silva, GSF;Cruz, JS;Teixeira, MM;Costa, VV;Machado, FS; A 5-Lipoxygenase Inhibitor, Zileuton, Modulates Host Immune Responses and Improves Lung Function in a Model of Severe Acute Respiratory Syndrome (SARS) Induced by Betacoronavirus Viruses 2023-10-04 [PMID: 37896826] (Mouse)
• Guo, ZF;Tongmuang, N;Li, C;Zhang, C;Hu, L;Capreri, D;Zuo, MX;Summer, R;Sun, J; Inhibiting endothelial cell Mst1 attenuates acute lung injury in mice bioRxiv : the preprint server for biology 2023-09-29 [PMID: 37808846] (Mouse)
• Hou, C;Jiang, X;Sheng, W;Zhang, Y;Lin, Q;Hong, S;Zhao, J;Wang, T;Ye, X; Xinmaikang (XMK) tablets alleviate atherosclerosis by regulating the SREBP2-mediated NLRP3/ASC/Caspase-1 signaling pathway Journal of ethnopharmacology 2023-09-28 [PMID: 37777030] (Mouse)
• Manandhar, S;Chambers, S;Miller, A;Ishii, I;Bhatia, M; Pharmacological Inhibition and Genetic Deletion of Cystathionine Gamma-Lyase in Mice Protects against Organ Injury in Sepsis: A Key Role of Adhesion Molecules on Endothelial Cells International journal of molecular sciences 2023-09-04 [PMID: 37686458] (Mouse, Transgenic Mouse)
• Hendrik Demuth, Shirin Hosseini, Henning Peter Düsedeau, Ildiko Rita Dunay, Martin Korte, Marta Zagrebelsky Deletion of p75NTR rescues the synaptic but not the inflammatory status in the brain of a mouse model for Alzheimer’s disease Frontiers in Molecular Neuroscience 2023-05-05 [PMID: 37213691] (Mouse)
• Gschwandtner, M;Gammage, AN;Deligne, C;Mies, LFM;Domaingo, A;Murdamoothoo, D;Loustau, T;Schwenzer, A;Derler, R;Carapito, R;Koch, M;M�rgelin, M;Orend, G;Kungl, AJ;Midwood, KS; Investigating Chemokine-Matrix Networks in Breast Cancer: Tenascin-C Sets the Tone for CCL2 International journal of molecular sciences 2023-05-06 [PMID: 37176074] (Mouse)
• C Zhang, ZF Guo, W Liu, K Kazama, L Hu, X Sun, L Wang, H Lee, L Lu, XF Yang, R Summer, J Sun PIMT is a novel and potent suppressor of endothelial activation Elife, 2023-04-18;12(0):. 2023-04-18 [PMID: 37070640] (Mouse)
• KD Marshall, PJ Klutho, L Song, R Roy, M Krenz, CP Baines Cardiac Myocyte-Specific Overexpression of FASTKD1 Prevents Ventricular Rupture After Myocardial Infarction Journal of the American Heart Association, 2023-02-15;12(4):e025867. 2023-02-15 [PMID: 36789858] (Mouse, Transgenic Mouse)
• TTT Nguyen, YH Choi, WK Lee, Y Ji, E Chun, YH Kim, JE Lee, HS Jung, JH Suh, S Kim, M Jin Tryptophan-dependent and -independent secretions of tryptophanyl- tRNA synthetase mediate innate inflammatory responses Cell Reports, 2022-12-30;42(1):111905. 2022-12-30 [PMID: 36640342] (Mouse)
• DC Sarver, C Xu, LM Velez, S Aja, AE Jaffe, MM Seldin, RH Reeves, GW Wong Dysregulated systemic metabolism in a Down syndrome mouse model Molecular Metabolism, 2022-12-29;68(0):101666. 2022-12-29 [PMID: 36587842] (Mouse)
• K Chen, LY Cheong, Y Gao, Y Zhang, T Feng, Q Wang, L Jin, E Honoré, KSL Lam, W Wang, X Hui, A Xu Adipose-targeted triiodothyronine therapy counteracts obesity-related metabolic complications and atherosclerosis with negligible side effects Nature Communications, 2022-12-20;13(1):7838. 2022-12-20 [PMID: 36539421] (Mouse)
• CS Rigazio, N Mariz-Pont, EP Caballero, FN Penas, NB Goren, MH Santamaría, RS Corral Involvement of glycoinositolphospholipid from Trypanosoma cruzi and macrophage migration inhibitory factor in proinflammatory mechanisms promoting cardiovascular injury mechanisms promoting cardiovascular inflammation tThe combined action of glycoinositolphospholipid from Trypanosoma cruzi and macrophage migration inhibitory factor increases proinflammatory mediator production by cardiomyocytes and vascular endothelial cells Microbial pathogenesis, 2022-11-12;0(0):105881. 2022-11-12 [PMID: 36379373] (Mouse)
• K Tange, S Yagi, E Takeshita, M Abe, Y Yamamoto, H Tomida, T Kawamura, M Hanayama, B Matsuura, Y Ikeda, Y Hiasa Oral administration of human carbonic anhydrase I suppresses colitis in a murine inflammatory bowel disease model Scientific Reports, 2022-10-26;12(1):17983. 2022-10-26 [PMID: 36289244] (Mouse)
• Y Ji, Y Liang, PH Chu, M Ge, SC Yeung, MS Man Ip, JC Wo Mak The effects of intermittent hypoxia on hepatic expression of fatty acid translocase CD36 in lean and diet-induced obese mice Biomedical journal, 2022-10-13;0(0):. 2022-10-13 [PMID: 36244649] (Mouse)
• J Liu, L Shi, W Huang, Z Zheng, X Huang, Y Su Homoharringtonine Attenuates Dextran Sulfate Sodium-Induced Colitis by Inhibiting NF-kappaB Signaling Mediators of Inflammation, 2022-09-29;2022(0):3441357. 2022-09-29 [PMID: 36211988] (Mouse)
• R Gawish, B Maier, G Obermayer, ML Watzenboec, AD Gorki, F Quattrone, A Farhat, K Lakovits, A Hladik, A Korosec, A Alimohamma, I Mesteri, F Oberndorfe, F Oakley, J Brain, L Boon, I Lang, CJ Binder, S Knapp A neutrophil-B-cell axis impacts tissue damage control in a mouse model of intraabdominal bacterial infection via Cxcr4 Elife, 2022-09-30;11(0):. 2022-09-30 [PMID: 36178806] (Mouse)
• N Milad, M Pineault, F Tremblay, J Routhier, A Lechasseur, MJ Beaulieu, S Aubin, MC Morissette Smoking status impacts treatment efficacy in smoke-induced lung inflammation: A pre-clinical study Frontiers in Pharmacology, 2022-09-07;13(0):971238. 2022-09-07 [PMID: 36160400] (Mouse)
• F Seidel, R Kleemann, W van Duyven, N van Trigt, N Keijzer, S van der Ko, C van Kooten, L Verschuren, A Menke, AJ Kiliaan, J Winter, TR Hughes, BP Morgan, F Baas, K Fluiter, MC Morrison Therapeutic Intervention with Anti-Complement Component 5 Antibody Does Not Reduce NASH but Does Attenuate Atherosclerosis and MIF Concentrations in Ldlr-/-.Leiden Mice International Journal of Molecular Sciences, 2022-09-14;23(18):. 2022-09-14 [PMID: 36142647] (Mouse)
• XY Choo, LE McInnes, A Grubman, JM Wasielewsk, I Belaya, E Burrows, H Quek, JC Martín, S Loppi, A Sorvari, D Rait, A Powell, C Duncan, JR Liddell, H Tanila, JM Polo, T Malm, KM Kanninen, PS Donnelly, AR White Novel Anti-Neuroinflammatory Properties of a Thiosemicarbazone-Pyridylhydrazone Copper(II) Complex International Journal of Molecular Sciences, 2022-09-14;23(18):. 2022-09-14 [PMID: 36142627] (Mouse)
• P Boroumand, DC Prescott, T Mukherjee, PJ Bilan, M Wong, J Shen, I Tattoli, Y Zhou, A Li, T Sivasubram, N Shi, LY Zhu, Z Liu, C Robbins, DJ Philpott, SE Girardin, A Klip Bone marrow adipocytes drive the development of tissue invasive Ly6Chigh monocytes during obesity Elife, 2022-09-20;11(0):. 2022-09-20 [PMID: 36125130] (Mouse)
• J Lee, SY Ahn, CTT Le, DH Lee, J Jung, EJ Ko Protective and vaccine dose-sparing efficacy of Poly I:C-functionalized calcium phosphate nanoparticle adjuvants in inactivated influenza vaccination International immunopharmacology, 2022-09-14;112(0):109240. 2022-09-14 [PMID: 36115278] (Mouse)
• SJ Matissek, M Karbalivan, W Han, A Boutilier, E Yzar-Garci, LL Kehoe, DS Gardner, A Hage, K Fleck, V Jeffers, R Rajsbaum, SF Elsawa A novel mechanism of regulation of the oncogenic transcription factor GLI3 by toll-like receptor signaling Oncotarget, 2022-08-03;13(0):944-959. 2022-08-03 [PMID: 35937499] (Mouse)
• J Faura, L Ramiro, A Simats, F Ma, A Penalba, T Gasull, A Rosell, J Montaner, A Bustamante Evaluation and Characterization of Post-Stroke Lung Damage in a Murine Model of Cerebral Ischemia International Journal of Molecular Sciences, 2022-07-22;23(15):. 2022-07-22 [PMID: 35897671] (Mouse)
• PS Woods, LM Kimmig, KA Sun, AY Meliton, OR Shamaa, Y Tian, R Cetin-Atal, WW Sharp, RB Hamanaka, GM Mutlu HIF-1alpha induces glycolytic reprograming in tissue-resident alveolar macrophages to promote cell survival during acute lung injury Elife, 2022-07-13;11(0):. 2022-07-13 [PMID: 35822617] (Mouse)
• B Dolfi, A Gallerand, MM Firulyova, Y Xu, J Merlin, A Dumont, A Castiglion, N Vaillant, S Quemener, H Gerke, MI Stunault, PR Schrank, SH Kim, A Zhu, J Ding, J Gilleron, V Magnone, P Barbry, D Dombrowicz, C Duranton, A Wakkach, C Blin-Wakka, B Becher, S Pagnotta, RJ Argüello, P Rantakari, S Chakarov, F Ginhoux, K Zaitsev, KW Kim, L Yvan-Charv, RR Guinamard, JW Williams, S Ivanov Unravelling the sex-specific diversity and functions of adrenal gland macrophages Cell Reports, 2022-06-14;39(11):110949. 2022-06-14 [PMID: 35705045] (Mouse)
• S Kim, W Lee, H Jo, SK Sonn, SJ Jeong, S Seo, J Suh, J Jin, HY Kweon, TK Kim, SH Moon, S Jeon, JW Kim, YR Kim, EW Lee, HK Shin, SH Park, GT Oh The antioxidant enzyme Peroxiredoxin-1 controls stroke-associated microglia against acute ischemic stroke Redox Biology, 2022-05-25;54(0):102347. 2022-05-25 [PMID: 35688114] (Mouse)
• H Choe, BS Hausman, KM Hujer, O Akkus, PN Rather, Z Lee, RA Bonomo, EM Greenfield Acinetobacter quorum sensing contributes to inflammation-induced inhibition of orthopaedic implant osseointegration Oncogene, 2022-06-09;43(0):267-276. 2022-06-09 [PMID: 35678763] (Mouse)
• A Moshensky, CS Brand, H Alhaddad, J Shin, JA Masso-Silv, I Advani, D Gunge, A Sharma, S Mehta, A Jahan, S Nilaad, J Olay, W Gu, T Simonson, D Almarghala, J Pham, S Perera, K Park, R Al-Kolla, H Moon, S Das, M Byun, Z Shah, Y Sari, J Heller Bro, LE Crotty Ale Effects of mango and mint pod-based e-cigarette aerosol inhalation on inflammatory states of the brain, lung, heart, and colon in mice Elife, 2022-04-12;11(0):. 2022-04-12 [PMID: 35411847] (Mouse)
• X Li, G He, J Liu, M Yan, M Shen, L Xu, M An, J Huang, Z Gao CCL2-mediated monocytes regulate immune checkpoint blockade resistance in pancreatic cancer International immunopharmacology, 2022-02-17;106(0):108598. 2022-02-17 [PMID: 35183036] (Mouse)
• X Gao, W Li, F Syed, F Yuan, P Li, Q Yu PD-L1 signaling in reactive astrocytes counteracts neuroinflammation and ameliorates neuronal damage after traumatic brain injury Journal of Neuroinflammation, 2022-02-08;19(1):43. 2022-02-08 [PMID: 35135580] (Mouse)
• R Pohl, S Feder, EM Haberl, L Rein-Fisch, TS Weiss, M Spirk, A Bruckmann, N McMullen, CJ Sinal, C Buechler Chemerin Overexpression in the Liver Protects against Inflammation in Experimental Non-Alcoholic Steatohepatitis Biomedicines, 2022-01-07;10(1):. 2022-01-07 [PMID: 35052810] (Mouse)
• HI Warheit-Ni, SJ Edwards, S SenGupta, CA Parent, X Zhou, DN O'Dwyer, BB Moore Fibrotic lung disease inhibits innate immune responses to Staphylococcal pneumonia via impaired neutrophil and macrophage function JCI Insight, 2022-02-22;0(0):. 2022-02-22 [PMID: 34990413] (Mouse)
• Taito Miyamoto, Ryusuke Murakami, Junzo Hamanishi, Kenji Tanigaki, Yuko Hosoe, Nathan Mise et al. B7-H3 Suppresses Antitumor Immunity via the CCL2–CCR2–M2 Macrophage Axis and Contributes to Ovarian Cancer Progression Cancer Immunology Research 2022-01-01 [PMID: 34799346] (Mouse)
• KKL Wu, K Long, H Lin, PMF Siu, RLC Hoo, D Ye, A Xu, KKY Cheng The APPL1-Rab5 axis restricts NLRP3 inflammasome activation through early endosomal-dependent mitophagy in macrophages Nature Communications, 2021-11-17;12(1):6637. 2021-11-17 [PMID: 34789781] (Mouse)
• YK Wu, ZN Ren, SL Zhu, YZ Wu, G Wang, H Zhang, W Chen, Z He, XL Ye, QX Zhai Sulforaphane ameliorates non-alcoholic fatty liver disease in mice by promoting FGF21/FGFR1 signaling pathway Acta pharmacologica Sinica, 2021-10-15;0(0):. 2021-10-15 [PMID: 34654875] (Mouse)
• C Luci, E Vieira, M Bourinet, D Rousseau, S Bonnafous, S Patouraux, L Lefevre, F Larbret, V Prod'homme, A Iannelli, A Tran, R Anty, B Bailly-Mai, M Deckert, P Gual SYK-3BP2 pathway activity in parenchymal and myeloid cells is a key pathogenic factor in metabolic steatohepatitis Cellular and Molecular Gastroenterology and Hepatology, 2021-08-16;0(0):. 2021-08-16 [PMID: 34411785] (Mouse)
• F Guo, M Seldin, M Péterfy, S Charugundl, Z Zhou, SD Lee, A Mouton, P Rajbhandar, W Zhang, M Pellegrini, P Tontonoz, AJ Lusis, DM Shih NOTUM promotes thermogenic capacity and protects against diet-induced obesity in male mice Scientific Reports, 2021-08-12;11(1):16409. 2021-08-12 [PMID: 34385484] (Mouse)
• DJ Levy, A Goundry, RSS Laires, TFR Costa, CM Novo, DJ Grab, JC Mottram, APCA Lima Role of the inhibitor of serine peptidase 2 (ISP2) of Trypanosoma brucei rhodesiense in parasite virulence and modulation of the inflammatory responses of the host PloS Neglected Tropical Diseases, 2021-06-21;15(6):e0009526. 2021-06-21 [PMID: 34153047] (Mouse)
• LG Lima, S Ham, H Shin, EPZ Chai, ESH Lek, RJ Lobb, AF Müller, S Mathivanan, B Yeo, Y Choi, BS Parker, A Möller Tumor microenvironmental cytokines bound to cancer exosomes determine uptake by cytokine receptor-expressing cells and biodistribution Nature Communications, 2021-06-10;12(1):3543. 2021-06-10 [PMID: 34112803] (Mouse)
• MTP de Oliveir, DS Coutinho, SS Guterres, AR Pohlmann, PMRE Silva, MA Martins, A Bernardi Resveratrol-Loaded Lipid-Core Nanocapsules Modulate Acute Lung Inflammation and Oxidative Imbalance Induced by LPS in Mice Pharmaceutics, 2021-05-10;13(5):. 2021-05-10 [PMID: 34068619] (Mouse)
• L Liu, Y Wu, B Wang, Y Jiang, L Lin, X Li, S Yang DA-DRD5 signaling controls colitis by regulating colonic M1/M2 macrophage polarization Cell Death & Disease, 2021-05-17;12(6):500. 2021-05-17 [PMID: 34001860] (Mouse)
• Chunmei Ma, Sheng Li, Yingchao Hu, Yan Ma, Yuqing Wu, Chunyan Wu et al. AIM2 controls microglial inflammation to prevent experimental autoimmune encephalomyelitis Journal of Experimental Medicine 2021-05-03 [PMID: 33710283] (Mouse)
• M Grancieri, HSD Martino, E Gonzalez d Protein Digests and Pure Peptides from Chia Seed Prevented Adipogenesis and Inflammation by Inhibiting PPAR&gamma and NF-&kappaB Pathways in 3T3L-1 Adipocytes Nutrients, 2021-01-08;13(1):. 2021-01-08 [PMID: 33430086] (Mouse)
• E Mai, CM Percopo, AR Limkar, AC Sek, M Ma, HF Rosenberg Respiratory Epithelial Cells Respond to Lactobacillus plantarum but Provide No Cross-Protection against Virus-Induced Inflammation Viruses, 2020-12-22;13(1):. 2020-12-22 [PMID: 33374950] (Mouse)
• M Song, OO Yeku, S Rafiq, T Purdon, X Dong, L Zhu, T Zhang, H Wang, Z Yu, J Mai, H Shen, B Nixon, M Li, RJ Brentjens, X Ma Tumor derived UBR5 promotes ovarian cancer growth and metastasis through inducing immunosuppressive macrophages Nature Communications, 2020-12-08;11(1):6298. 2020-12-08 [PMID: 33293516] (Mouse)
• A Taberner-C, Á Vinué, A Herrero-Ce, M Aguilar-Ba, JT Real, DJ Burks, S Martínez-H, H González-N Dapagliflozin Does Not Modulate Atherosclerosis in Mice with Insulin Resistance International Journal of Molecular Sciences, 2020-12-03;21(23):. 2020-12-03 [PMID: 33287201] (Mouse)
• AM Antonson, MV Evans, JD Galley, HJ Chen, TA Rajasekera, SM Lammers, VL Hale, MT Bailey, TL Gur Unique maternal immune and functional microbial profiles during prenatal stress Sci Rep, 2020-11-20;10(1):20288. 2020-11-20 [PMID: 33219314] (Mouse)
• AS Khan, T Langmann Indole-3-carbinol regulates microglia homeostasis and protects the retina from degeneration J Neuroinflammation, 2020-11-03;17(1):327. 2020-11-03 [PMID: 33143743] (Mouse)
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FAQs for CCL2/JE/MCP-1 (DY479). (Showing 1 - 1 of 1 FAQs).

1. What is the difference between the Quantikine and Duoset ELISA kits?
   • Our Quantikine kits are fully optimized and validated for the sample types listed on the product specific webpage and datasheet, as this can vary between kits. Each kit is supplied ready to use with one pre-coated 96-well plate, a detection antibody directly conjugated to HRP, and all other necessary reagents. These kits are ideal for researchers who want the convenience of a ready to use and optimized ELISA product. Some of these kits are also available prepackaged in larger 6 and 50 plate sizes.Our DuoSet Kits, in contrast, are ELISA development kits containing the capture and detection antibody, the mass-value calibrated standard, and streptavidin-HRP to prepare approximately 5 or 15 plates. Ancillary reagents will need to be used/purchased, and for most kits, we will recommend one of our Ancillary Reagent Kits, which contain the reagents we use ourselves in-house. DuoSet kits are validated only for cell culture supernatant samples and therefore require further development and validation for accurate measurement in more complex samples such as serum and plasma. Our DuoSet Kits offer an economical, flexible alternative for the experienced ELISA user.

Bioinformatics

• Gene Symbol: Ccl2