MMRN2 Antibody - Azide and BSA Free

Western Blot: MMRN2 Antibody [H00079812-B01P] - Analysis of MMRN2 expression in transfected 293T cell line by MMRN2 polyclonal antibody. Lane 1: MMRN2 transfected lysate(104.39 KDa). Lane 2: Non-transfected lysate.

• Reactivity: Hu
• Applications: WB, ICC/IF, IHC, IP
• Clonality: Polyclonal
• Host: Mouse
• Conjugate: Unconjugated
• Format: Azide and BSA Free

MMRN2 Antibody - Azide and BSA Free Summary

• Immunogen: MMRN2 (AAH94744.1, 1 a.a. - 949 a.a.) full-length human protein. MILSLLFSLGGPLGWGLLGAWAQASSTSLSDLQSSRTPGVWKAEAEDTGKDPVGRNWCPYPMSKLVTLLALCKTEKFLIHSQQPCPQGAPDCQKVKVMYRMAHKPVYQVKQKVLTSLAWRCCPGYTGPNCEHHDSMAIPEPADPGDSHQEPQDGPVSFKPGHLAAVINEVEVQQEQQEHLLGDLQNDVHRVADSLPGLWKALPGNLTAAVMEANQTGHEFPDRSLEQVLLPHVDTFLQVHFSPIWRSFNQSLHSLTQAIRNLSLDVEANRQAISRVQDSAVARADFQELGAKFEAKVQENTQRVGQLRQDVEDRLHAQHFTLHRSISELQADVDTKLKRLHKAQEAPGTNGSLVLATPGAGARPEPDSLQARLGQLQRNLSELHMTTARREEELQYTLEDMRATLTRHVDEIKELYSESDETFDQISKVERQVEELQVNHTALRELRVILMEKSLIMEENKEEVERQLLELNLTLQHLQGGHADLIKYVKDCNCQKLYLDLDVIREGQRDATRALEETQVSLDERRQLDGSSLQALQNAVDAVSLAVDAHKAEGERARAATSRLRSQVQALDDEVGALKAAAAEARHEVRQLHSAFAALLEDALRHEAVLAALFGEEVLEEMSEQTPGPLPLSYEQIRVALQDAASGLQEQALGWDELAARVTALEQASEPPRPAEHLEPSHDAGREEAATTALAGLARELQSLSNDVKNVGRCCEAEAGAGAASLNASLDGLHNALFATQRSLEQHQRLFHSLFGNFQGLMEANVSLDLGKLQTMLSRKGKKQQKDLEAPRKRDKKEAEPLVDIRVTGPVPGALGAALWEAGSPVAFYASFSEGTAALQTVKFNTTYINIGSSYFPEHGYFRAPERGVYLFAVSVEFGPGPGTGQLVFGGHHRTPVCTTGQGSGSTATVFAMAELQKGERVWFELTQGSITKRSLSGTAFGGFLMFKT
• Isotype: IgG
• Clonality: Polyclonal
• Host: Mouse
• Gene: MMRN2
• Purity: Protein G purified

Applications/Dilutions

• Dilutions:
  • Immunocytochemistry/ Immunofluorescence
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin
  • Immunoprecipitation
  • Western Blot 1:100-1:2000
• Application Notes: This antibody is useful for Western Blot, Functional. Use in immunoprecipitation reported in scientific literature (PMID:28671670).

Packaging, Storage & Formulations

• Storage: Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
• Buffer: PBS (pH 7.4)
• Preservative: No Preservative
• Purity: Protein G purified

Notes

This product is produced by and distributed for Abnova, a company based in Taiwan.

Alternate Names for MMRN2 Antibody - Azide and BSA Free

• Elastin microfibril interface located protein 3
• Elastin microfibril interfacer 3EMILIN-3
• EMILIN3
• EMILIN-like protein EndoGlyx-1
• EndoGlyx-1 p125/p140 subunit
• Endoglyx-1
• FLJ13465
• MMRN2
• multimerin 2
• multimerin-2

Background

The MMRN2 gene encodes a 949 amino acid long, 104 kDA multimerin-2 protein that prevents endothelial cells motility. The elastic microfibril interface-located (EMILIN) protein family is an extracellular matrix glycoprotein. Additionally, this protein acts as a negative regulator of angiogenesis by downregulating activation by binding VEGFA. MMRN2 has been linked to adenocarcinoma and skin cancer as it participates in MAPK signaling, PTEN pathway, transendothelial migration of leukocytes, and UPA-UPAR pathway. It has been known to interact with genes VDR, MAPK7, MAP3K3, and DAXX.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for MMRN2 Antibody (H00079812-B01P)(2)

Publications using H00079812-B01P

• Khan KA, Naylor AJ, Khan A et al. Multimerin-2 is a ligand for group 14 family C-type lectins CLEC14A, CD93 and CD248 spanning the endothelial pericyte interface. Oncogene. [PMID: 28671670] (IP, WB, Human)
• Noy PJ, Lodhia P, Khan K et al. Blocking CLEC14A-MMRN2 binding inhibits sprouting angiogenesis and tumour growth. Oncogene. 2014-12-12 [PMID: 25745997]

Bioinformatics

• Gene Symbol: MMRN2
• Uniprot:
  • AAH94744.1(Human)