MMP-2 Antibody (1A10) [Alexa Fluor® 350] Summary
Chinese hamster ovary cell line CHO-derived recombinant human MMP-2
Detects the pro and active forms of human MMP-2 in Western blots. In dot blots, no cross-reactivity with recombinant human MMP-1, -3, -7,
-8, -9, -10, -12, or -13 is observed.
Test in a species/application not listed above to receive a full credit towards a future purchase.
- Intracellular Staining by Flow Cytometry 0.25-1 ug/10^6 cells
Packaging, Storage & Formulations
Store the unopened product at 2 - 8 °C. Do not use past expiration date.
Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.
This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.
Alternate Names for MMP-2 Antibody (1A10) [Alexa Fluor® 350]
- 72 kDa gelatinase
- CLG4A72 kDa type IV collagenase
- collagenase type IV-A
- EC 3.4.24
- EC 18.104.22.168
- Gelatinase A
- matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IVcollagenase)
- matrix metalloproteinase 2 (gelatinase A, 72kD gelatinase, 72kD type IVcollagenase)
- Matrix metalloproteinase-2
- matrix metalloproteinase-II
- neutrophil gelatinase
- TBE-1matrix metalloproteinase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IVcollagenase)
metalloproteinases are a family of zinc and calcium dependent
endopeptidases with the combined ability to degrade all the components
of the extracellular matrix. MMP‑2 (gelatinase A), a type IV
collagenase, can degrade a broad range of substrates including type IV,
V, VII and X collagens as well as elastin and fibronectin. It is
believed to act synergistically with interstitial collagenase (MMP‑1) in
the degradation of fibrillar collagens as it degrades their denatured
gelatin forms. MMP‑2 has been shown to be associated with many
connective tissue cells as well as neutrophils, macrophages and
monocytes. Structurally, MMP‑2 may be divided into several distinct
domains: a pro-domain which is cleaved upon activation; a catalytic
domain containing the zinc binding site; a fibronectin-like domain
thought to play a role in substrate targeting; and a carboxyl terminal
(hemopexin-like) domain containing 2 N-linked glycosylation sites.
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed
for 1 year from date of receipt.
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