MMP-14/MT1-MMP Antibody (MM0027-9E10) Summary
This antibody was produced from a hybridoma (mouse myeloma fused with spleen cells from a mouse immunized with purified human recombinant MMP-14.
Membrane; Single-pass type I membrane protein. Melanosome.
This antibody recognizes human MMP-14 in western blot without cross reactivity with human MMP-1-13, and MMP14-15.
Protein G purified
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- Western Blot 1:400-1:800
- Immunohistochemistry 1:50-200
- Immunohistochemistry-Paraffin 1:50-200
Packaging, Storage & Formulations
Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
A 0.2 um filtered solution in PBS
Protein G purified
Reconstitute with 0.5 ml sterilized PBS to a final concentration of 0.2 mg/ml.
Alternate Names for MMP-14/MT1-MMP Antibody (MM0027-9E10)
- EC 3.4.24
- EC 22.214.171.124
- matrix metallopeptidase 14 (membrane-inserted)
- matrix metalloproteinase 14 (membrane-inserted)
- matrix metalloproteinase-14
- membrane type 1 metalloprotease
- Membrane-type matrix metalloproteinase 1
- Membrane-type-1 matrix metalloproteinase
- MT-MMP 1
The matrix metalloproteinases (MMPs) are a family of at least eighteen secreted and membrane bound zincendopeptidases. Collectively, these enzymes can degrade all the components of the extracellular matrix, including fibrillar and non fibrillar collagens, fibronectin, laminin and basement membrane glycoproteins. In general, a signal peptide, a propeptide, and a catalytic domain containing the highly conserved zinc binding site characterizes the structure of the MMPs. In addition, fibronectin like repeats, a hinge region, and a C terminal hemopexin like domain allow categorization of MMPs into the collagenase, gelatinase, stomelysin and membrane-type MMP subfamilies. All MMPs are synthesized as proenzymes, and most of them are secreted from the cells as proenzymes. Thus, the activation of these proenzymes is a critical step that leads to extracellular matrix breakdown. MMPs are considered to play an important role in wound healing, apoptosis, bone elongation, embryo development, uterine involution, angiogenesis and tissue remodeling, and in diseases such as multiple sclerosis, Alzheimer's, malignant gliomas, lupus, arthritis, periodontis, glumerulonephritis, atherosclerosis, tissue ulceration, and in cancer cell invasion and metastasis. MMP14 may be an activator of pro gelatinase A and is expressed in fibroblast cells during both wound healing and human cancer progression. MMP14 is expressed in very low levels and may require stimulation with concanavolin A or the phorbol ester TPA to stimulate production of MMP14.
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed
for 1 year from date of receipt.
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