MMP-14/MT1-MMP Products

Antibodies
MMP-14/MT1-MMP Antibody
MMP-14/MT1-MMP Antibody
NB100-91872
Species: Hu, Mu, Rt
Applications: WB, IHC, IHC-P
Host: Rabbit Polyclonal
MMP-14/MT1-MMP Antibody
MMP-14/MT1-MMP Antibody
AF918
Species: Hu
Applications: WB, Flow, IHC
Host: Goat Polyclonal
Lysates
MMP-14/MT1-MMP Overexpression ...
MMP-14/MT1-MMP Overexpression Lysa...
NBL1-13153
Applications: WB
MMP-14/MT1-MMP Overexpression ...
MMP-14/MT1-MMP Overexpression Lysa...
H00004323-T02
Applications: WB
Proteins
MMP-14/MT1-MMP Recombinant Pr ...
MMP-14/MT1-MMP Recombinant Protein
H00004323-P01
Species: Hu
Applications: WB, ELISA, PA
MMP-14/MT1-MMP Recombinant Pr ...
MMP-14/MT1-MMP Recombinant Protein...
NBP2-38649PEP
Species: Hu
Applications: AC
MMP-14/MT1-MMP Recombinant Pr ...
MMP-14/MT1-MMP Recombinant Protein
NBP2-53057
Species: Hu
Applications: PAGE
RNAi
MMP-14/MT1-MMP RNAi
MMP-14/MT1-MMP RNAi
H00004323-R01
Species: Hu

Description

The matrix metalloproteinase (MMP) family (approximately 25 members in mammals) has been implicated in extracellular matrix remodeling associated with embryonic development, cancer formation and progression, and various other physiological and pathological events. MMP-14 is a membrane-bound matrix metalloproteinase (MT-MMP) capable of mediating pericellular proteolysis of extracellular matrix components. MMP-14 is therefore thought to be an important molecular tool for cellular remodeling of the surrounding matrix (1). Gelatinase A (type-IV collagenase; M(r) 72,000) is produced by tumour stroma cells and is believed to be crucial for their invasion and metastasis, acting by degrading extracellular matrix macro-molecules such as type IV collagen. MMP-14 may thus trigger invasion by tumor cells by activating pro-gelatinase A on the tumor cell surface (2). Observations identify MT1-MMP as a tumor-derived growth factor that regulates proliferation by controlling cell geometry within the confines of the 3D extracellular matrix (ECM) (3).

Bioinformatics

Entrez Human
Mouse
Rat
Uniprot Human
Human
Human
Human
Human
Product By Gene ID 4323
Alternate Names
  • EC 3.4.24
  • MMP-X1
  • membrane type 1 metalloprotease
  • MMP-14
  • matrix metalloproteinase-14
  • Membrane-type-1 matrix metalloproteinase
  • EC 3.4.24.80
  • Membrane-type matrix metalloproteinase 1
  • MT-MMP 1
  • matrix metalloproteinase 14 (membrane-inserted)
  • MT1-MMPMTMMP1
  • MT1MMP
  • matrix metallopeptidase 14 (membrane-inserted)

Research Areas for MMP-14/MT1-MMP

Find related products by research area and learn more about each of the different research areas below.

Cancer
Extracellular Matrix

Bioinformatics Tool for MMP-14/MT1-MMP

Discover related pathways, diseases and genes to MMP-14/MT1-MMP. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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