MLL5 Antibody - BSA Free

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Immunohistochemistry-Paraffin: MLL5 Antibody [NBP2-33775] - Staining of human bone marrow shows strong positivity in a subset of hematopoietic cells.

Product Details

Summary
Reactivity HuSpecies Glossary
Applications IHC
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated
Format
BSA Free

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Catalog# & Formulation Size Price

MLL5 Antibody - BSA Free Summary

Description
Novus Biologicals Rabbit MLL5 Antibody - BSA Free (NBP2-33775) is a polyclonal antibody validated for use in IHC. All Novus Biologicals antibodies are covered by our 100% guarantee.
Immunogen
This antibody was developed against a recombinant protein corresponding to amino acids: TYSQEGYDRSSTMLTLGPFRNSNLTELGLQEIKTIGYTSPRSRTEVNRQCPGEKEPVSDLQLGLDAVEPTALHKTLETPAHDRAEPNSQLDSTH
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
KMT2E
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Immunohistochemistry 1:200 - 1:500
  • Immunohistochemistry-Paraffin 1:200 - 1:500
Application Notes
For IHC-Paraffin, HIER pH 6 retrieval is recommended.
Control Peptide
MLL5 Protein (NBP2-33775PEP)

Reactivity Notes

Immunogen displays the following percentage of sequence identity for non-tested species: Mouse (87%)

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS (pH 7.2) and 40% Glycerol
Preservative
0.02% Sodium Azide
Purity
Immunogen affinity purified

Alternate Names for MLL5 Antibody - BSA Free

  • EC 2.1.1.43
  • FLJ10078
  • HDCMC04P
  • histone-lysine N-methyltransferase MLL5
  • KMT2EFLJ14026
  • Lysine N-methyltransferase 2E
  • MGC70452
  • myeloid/lymphoid or mixed-lineage leukemia 5 (trithorax homolog, Drosophila)
  • Myeloid/lymphoid or mixed-lineage leukemia protein 5

Background

MLL5 is a divergent member of the Drosophila Trithorax related SET and PHD domain containing chromatin regulators that are involved in the regulation of transcriptional "memory" during differentiation. Human MLL5 is located on chromosome 7q22, that is frequently deleted in myeloid leukemias. Inactivation of the Mll5 gene in mice results in a reduction in the average representation of hematopoietic stem cells, and in functional impairment of long term hematopoietic repopulation potential under competitive conditions. Overexpression of the protein also inhibits cell cycle progression.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Secondary Antibodies

 

Isotype Controls

Additional MLL5 Products

Array NBP2-33775

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Bioinformatics

Gene Symbol KMT2E
Uniprot