MINA Antibody (753002) [Alexa Fluor™ Plus 647]

• Reactivity: Hu
• Clone: 753002
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor Plus 647

MINA Antibody (753002) [Alexa Fluor™ Plus 647] Summary

• Specificity: Detects human MINA in direct ELISAs. In direct ELISAs, approximately 50% cross-reactivity with recombinant mouse MINA is observed.
• Isotype: IgG1
• Clonality: Monoclonal
• Host: Mouse

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for MINA Antibody (753002) [Alexa Fluor™ Plus 647]

• DKFZp762O1912
• FLJ14393
• MDIG
• MDIGDKFZp762O1912
• MINA
• Mina53
• MINA53mdig
• mineral dust induced gene protein
• Mineral dust-induced gene protein
• MYC induced nuclear antigen
• MYC-induced nuclear antigen
• myc-induced nuclear antigen, 53 kDa
• NO52
• Nucleolar protein 52

Background

MINA (myc-induced nuclear antigen; also Mina53) is a 52-54 kDa member of both the MINA53/NO66 and Jumonji C family of proteins. It expression is associated with proliferating cells, and it has been found in cytoplasm, nucleus and nucleoli. MINA appears to be induced by c-myc, and synthesized by spermatogonia, occasional squamous epithelium, naïve T cells and select cancer cells. When expressed, MINA is reported to regulate expression of genes such as HGF, EGF-R and IL-4. It may exert its regulatory activity through an intrinsic demethylase function. Mouse MINA is 465 amino acids (aa) in length. It possesses one cupin (or enzyme‑associated) region (aa 51-363) that contains a JmjC domain (aa 139-271). There are two potential isoform variants that contain either a 12 aa substitution for aa 145‑465, or a 15 aa substitution for aa 228-465. Over aa 2-192, mouse MINA shares 92% and 82% aa sequence identity with rat and human MINA, respectively.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.