MICA/B Antibody (6D4)

Images

 
Flow Cytometry: MICA/B Antibody (6D4) [NB100-78034] - Analysis using the Biotin conjugate of NB100-78034. Staining of Human Hela cell line biotinylated 6D4, followed by Sav-PE.
Flow Cytometry: MICA/B Antibody (6D4) [NB100-78034] - man Hela cell line stained with purified 6D4, followed by anti-mouse IgG FITC

Product Details

Summary
Product Discontinued
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Order Details


    • Catalog Number
      NB100-78034
    • Availability
      Product Discontinued

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MICA/B Antibody (6D4) Summary

Immunogen
The immunogen was the full length version of the protein: MICA/MICB (6D4)
Isotype
IgG2a Kappa
Clonality
Monoclonal
Host
Mouse
Gene
MICA
Purity
Protein A or G purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Flow Cytometry < = 0.5 ug/10^6 cells in 100 ul
  • Immunohistochemistry-Paraffin
Application Notes
Additional reported applications include: immunohistochemistry of acetone-fixed frozen sections and formalin-fixed paraffin-embedded tissue sections, immunoprecipitation, and blocking of MIC mediated cytotoxicity. Use in Immunohistochemistry-Paraffin reported in scientific literature (PMID 25510288)
Publications
Read Publications using
NB100-78034 in the following applications:

Packaging, Storage & Formulations

Storage
Store at 4C. Do not freeze.
Buffer
PBS (pH 7.2)
Preservative
0.09% Sodium Azide
Concentration
0.5 mg/ml
Purity
Protein A or G purified

Alternate Names for MICA/B Antibody (6D4)

  • MHC class I chain-related protein A
  • MHC class I chain-related protein B
  • MIC
  • MICA
  • MICA/B
  • MICB
  • PERB11
  • PERB11.1
  • PERB11.2

Background

6D4 antibody reacts with a common epitope of the human nonclassical MHC class I chain-related protein A (MICA) and B (MICB), also known as PERB11.1 and PERB11.2. The MIC gene is located in MHC class I region. MICA/B are 65-75 kD stress-inducible glycoproteins with highly polymorphic. They are MHC class I-like transmembrane molecules that do not associate beta2-microglobulin and do not present peptides. MICA and MICB share 85% identify, and are mainly expressed on Intestinal epithelial cells, epithelial tumor cells, endothelial cells, fibroblasts, and IFN- alpha-stimulated dendritic cells. MIC molecules bind NKG2D, an activating receptor, and induce activation of NK cells, and subset of CD8+ alpha/ beta T cells and gamma/ delta T cells, as well as suppression of T cell proliferation. MICA/B recognition is involved in the regulation of tumor surveillance, viral infection and autoimmune diseases. The 6D4 antibody is able to block MIC mediated cytotoxicity.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for MICA/B Antibody (NB100-78034)(2)

We have publications tested in 1 confirmed species: Human.

We have publications tested in 1 application: IHC-P.


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IHC-P
(1)
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Human
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Secondary Antibodies

 

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Additional MICA/B Products

MICA/B NB100-78034

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Bioinformatics

Gene Symbol MICA
Entrez