Recombinant Human MIA Protein

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Product Details

Summary
Reactivity HuSpecies Glossary
Applications PAGE, HPLC
Concentration
Lyoph

Order Details

Recombinant Human MIA Protein Summary

Description
Recombinant bioactive protein containing 108 amino acids for Human MIA

Source:E. coli
Amino Acid Sequence:(Q16674)

Preparation
Method
>98% SDS-PAGE
Details of Functionality
The biological activity is determined by the inhibitory effect on the invasion of Mel In Tumor cells and found active in Mel In assay.
Source
E. coli
Protein/Peptide Type
Biologically Active Protein
Gene
MIA
Purity
>95%, by SDS-PAGE
Endotoxin Note
<0.1 ng/ug

Applications/Dilutions

Theoretical MW
12.2 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Packaging, Storage & Formulations

Storage
Store at -20 to -80C. Avoid freeze-thaw cycles.
Buffer
Sterile filtered and lyophilized with no additives
Concentration
Lyoph
Purity
>95%, by SDS-PAGE
Reconstitution Instructions
Reconstitute in H2O to a concentration of 0.1-1.0 mg/ml. The solution can then be diluted into other aqueous buffers

Alternate Names for Recombinant Human MIA Protein

  • CD-RAP
  • Melanoma inhibitory activity protein
  • melanoma inhibitory activity
  • melanoma-derived growth regulatory protein
  • MIA

Background

MIA is the first discovered member of a family of secreted cytokines termed the MIA/OTOR family. The four known members of this family; MIA, MIA2, OTOR and TANGO each contain a Src homology-3 (SH3)-like domain. MIA is an autocrine growth regulatory protein secreted from chondrocytes and malignant melanoma cells that promotes melanoma metastasis by binding competitively to fibronectin and laminin in a manner that results in melanoma cell detachment from the extraCellular matrix in vivo. Elevated levels of MIA may represent a clinically useful marker for diagnosis of melanoma metastasis as well as a potential marker for rheumatoid arthritis. Recombinant human MIA is a 12.2 kDa globular protein containing 108 amino acid residues including two intramolecular disulfide bonds.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Peptides and proteins are guaranteed for 2 years from date of receipt.

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Bioinformatics

Gene Symbol MIA
Entrez