MIA Recombinant Protein Summary
A recombinant protein corresponding to 108 amino acids of Human MIA
Source: E. coli
Amino Acid Sequence: The amino acid sequence of this product is not available.
|Details of Functionality
The biological activity is determined by the inhibitory effect on the invasion of Mel In Tumor cells and found active in Mel In assay.
Packaging, Storage & Formulations
Store at -20C. Avoid freeze-thaw cycles.
Sterile filtered and with no additives.
Reconstitute with water to a final concentration of 0.1 - 1.0 mg/ml.
After reconstituted, dilute further with other aqueous solutions.
Alternate Names for MIA Recombinant Protein
- Melanoma inhibitory activity protein
- melanoma inhibitory activity
- melanoma-derived growth regulatory protein
MIA is the first discovered member of a family of secreted cytokines termed the MIA/OTOR family. The four known members of this family; MIA, MIA2, OTOR and TANGO each contain a Src homology-3 (SH3)-like domain. MIA is an autocrine growth regulatory protein secreted from chondrocytes and malignant melanoma cells that promotes melanoma metastasis by binding competitively to fibronectin and laminin in a manner that results in melanoma cell detachment from the extraCellular matrix in vivo. Elevated levels of MIA may represent a clinically useful marker for diagnosis of melanoma metastasis as well as a potential marker for rheumatoid arthritis. Recombinant human MIA is a 12.2 kDa globular protein containing 108 amino acid residues including two intramolecular disulfide bonds.
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Peptides and proteins are guaranteed
for 3 months from date of receipt.
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