mGluR5 Antibody (464823) [Alexa Fluor® 488]

• Applications: IHC
• Clone: 464823
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor 488

mGluR5 Antibody (464823) [Alexa Fluor® 488] Summary

• Immunogen: Mouse myeloma cell line NS0-derived recombinant human mGluR5
  Ser19-Ser509
  Accession # P41594
• Specificity: Detects human mGLUR in direct ELISAs and Western blots.
• Isotype: IgG2b
• Clonality: Monoclonal
• Host: Mouse
• Purity Statement: Protein A or G purified

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Background

Human metabotropic glutamate receptor 5 (mGluR5; also known as mGluR5b) is a 150 kDa, 7-transmembrane glycoprotein that belongs to group I of the C-family of G-protein coupled receptors. mGluR5 is constitutively expressed and regulates neuronal ion channel activity. Human mGluR5 is 1212 amino acids (aa) in length and contains an N-terminal extracellular domain (ECD) of 558 aa. Through its ECD, mGluR5 either homodimerizes or heterodimerizes with the Ca⁺⁺-sensor receptor. There is one alternate splice form (mGluR5a) that shows a 32 aa deletion between aa 877-908 in the cytoplasmic tail. Over aa 21-509, human mGluR5 shares 98% aa sequence identity with mouse, rat, and dog mGluR5.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.