mGluR1 Antibody (511601) [Alexa Fluor™ Plus 488]

• Reactivity: Hu
• Clone: 511601
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor Plus 488

mGluR1 Antibody (511601) [Alexa Fluor™ Plus 488] Summary

• Specificity: Detects human mGluR1a in direct ELISAs.
• Isotype: IgG2a
• Clonality: Monoclonal
• Host: Mouse

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for mGluR1 Antibody (511601) [Alexa Fluor™ Plus 488]

• glutamate receptor, metabotropic 1
• GPRC1A
• GRM1
• GRM1A
• metabotropic glutamate receptor 1
• mGluR1
• MGLUR1A
• MGLUR1GPRC1AmGlu1

Background

Metabotropic glutamate receptor 1 (mGluR1 alpha ) is a 130 kDa, 7-transmembrane glycoprotein that belongs to group I of the C-family of G-protein coupled receptors. On neurons, mGluR1 is postsynaptic, associates with G_q-like proteins, mobilizes intracellular Ca⁺⁺, and influences ion channel activity. Mature mGluR1 is 1176 amino acids (aa) in length and contains a 574 aa N-terminal extracellular domain (ECD) (aa 19‑592). The ECD binds glutamate and forms either a covalent homodimer, or heterodimer with CaSR. There is one alternative splice form for human mGluR1 that shows a 20 aa substitution for the C-terminal 308 amino acids. Over aa 33‑522, human mGluR1 shares more that 98% aa identity with mouse, rat and canine mGluR1.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.