MEX3C Antibody - BSA Free

Western Blot: MEX3C Antibody [NBP1-76341] - Rat heart tissue lysate with MEX3C antibody at (A) 0.5 ug/mL and (B) 1 ug/mL.

• Reactivity: Hu, Mu, Rt
• Applications: WB, ELISA, ICC/IF
• Clonality: Polyclonal
• Host: Rabbit
• Conjugate: Unconjugated
• Format: BSA Free
• Concentration: 1 mg/ml

MEX3C Antibody - BSA Free Summary

• Immunogen: Antibody was raised against a 15 amino acid synthetic peptide from near the carboxy terminus of human RKHD2. The immunogen is located within amino acids 540 - 590 of Rkhd2. Amino Acid Squence: LARRVRSDPPSTGNH
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: MEX3C
• Purity: Peptide affinity purified

Applications/Dilutions

• Dilutions:
  • ELISA 1:100-1:2000
  • Immunocytochemistry/ Immunofluorescence
  • Western Blot 0.5-1 ug/ml
• Application Notes: Use in ICC/IF reported in scientific literature (PMID: 30741721).
• Control Peptide:

  MEX3C Peptide (NBP1-76341PEP)

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: PBS
• Preservative: 0.02% Sodium Azide
• Concentration: 1 mg/ml
• Purity: Peptide affinity purified

Alternate Names for MEX3C Antibody - BSA Free

• BM-013
• FLJ38871
• mex-3 homolog C (C. elegans)
• ring finger and KH domain containing 2
• RING finger protein 194
• RNA-binding protein MEX3C
• RNF194

Background

Rkhd2, also known as MEX3C is a member of a novel family of four homologous human MEX3 proteins each containing two heterogeneous nuclear ribonucleoprotein K homology (KH) domains and one carboxy-terminal RING finger module. MEX3 proteins, including Rkhd2, are phosphoproteins that bind RNA through their KH domains and shuttle between the nucleus and the cytoplasm via the CRM1 export pathway. These proteins are a novel family of evolutionarily conserved RNA-binding proteins, differentially recruited to P bodies and potentially involved in post-transcriptional regulatory mechanisms. It has been suggested that genetic variations in Rkhd2 may be associated with susceptibility to essential hypertension type 8. Rkhd3 and Rkhd4, but not Rkhd2, co-localize with both the hDcp1a decapping factor and Argonaute (Ago) proteins in processing bodies (P bodies), recently characterized as centers of mRNA turnover.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for MEX3C Antibody (NBP1-76341)(1)

Publication using NBP1-76341

• Li Y, Hu Q, Li C et al. PTEN-induced partial epithelial-mesenchymal transition drives diabetic kidney disease J. Clin. Invest. 2019-03-01 [PMID: 30741721] (ICC/IF, Mouse)

Bioinformatics

• Gene Symbol: MEX3C
• Uniprot:
  • NP_057710(Human)