MBP Antibody

Images

 
Immunohistochemistry-Paraffin: MBP Antibody [NB100-872] - Formalin fixed paraffin embedded brain.
Immunohistochemistry-Paraffin: MBP Antibody [NB100-872] - Formalin fixed paraffin embedded human brain stained with MBP antibody.
Immunohistochemistry-Paraffin: MBP Antibody [NB100-872] - Staining of brain medula.

Product Details

Summary
Reactivity Hu, RtSpecies Glossary
Applications IHC, IHC-Fr, IHC-P
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated

Order Details

MBP Antibody Summary

Immunogen
Human myelin basic protein isolated from normal human brain.
Localization
Cytoplasmic
Marker
Oligodendrocyte Marker, Myelin Marker
Specificity
This reacts with human myelin basic protein and oligodendrocytes of white matter in brain and spinal cord. Grey matter stains weakly. This also stains peripheral nerves.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
MBP
Purity
Unpurified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Frozen 1:10-1:500
  • Immunohistochemistry-Paraffin 1:10-1:500
Application Notes
This antibody may be diluted to a titer of 1:50-1:100 in an ABC allmethod. We suggest an incubation period of 30 minutes at room temperature. Suitable for formalin/paraffin tissues. Depending upon the fixation conditions and the staining system employed, optimal incubation conditions should be determined by the end user. IHC-Fr: 1/1000
Publications
Read Publication using NB100-872.

Packaging, Storage & Formulations

Storage
Store at 4C. Do not freeze.
Buffer
Whole antisera
Preservative
Sodium Azide
Purity
Unpurified

Alternate Names for MBP Antibody

  • Hmbpr
  • MBP
  • MGC99675
  • mld
  • Myelin A1 protein
  • myelin basic protein
  • Myelin membrane encephalitogenic protein
  • shi

Background

The classic group of Myelin basic protein (MBP) isoforms (isoforms 4 to 14) are with PLP the most abundant protein components of the myelin membrane in the CNS. They have a role in both its formation and stabilization. The smaller isoforms might have an important role in remyelination of denuded axons in multiple sclerosis. The non classic group of MBP isoforms (isoforms 1 to 3/Golli MBPs) may preferentially have a role in the early developing brain long before myelination, maybe as components of transcriptional complexes, and may also be involved in signaling pathways in T cells and neural cells. Differential splicing events combined to optional posttranslational modifications give a wide spectrum of isomers, each of them having maybe a specialized function.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for MBP Antibody (NB100-872)(1)

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Product General Protocols

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FAQs for MBP Antibody (NB100-872). (Showing 1 - 1 of 1 FAQ).

  1. Is your antibody NB100-872 indicated for IHC ion mouse tissue? 
    • NB100-872 has not yet been validated in mouse. It has been validated in frozen tissue sections on human and rat. We have not yet tested it in mouse and do not have any further information available.

Secondary Antibodies

 

Isotype Controls

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Bioinformatics

Gene Symbol MBP
Entrez