MAP4K1 Antibody (1G6) - Azide and BSA Free

Western Blot: MAP4K1 Antibody (1G6) [H00011184-M02-100ug] - Detection against Immunogen (36.63 KDa) .

Western Blot: MAP4K1 Antibody (1G6) [H00011184-M02-100ug] - Monoclonal antibody (M02), clone 1G6. Western Blot analysis of MAP4K1 expression in Jurkat.

ELISA: MAP4K1 Antibody (1G6) [H00011184-M02-100ug] - Detection limit for recombinant GST tagged MAP4K1 is 0.03 ng/ml as a capture antibody.

• Reactivity: Hu
• Applications: WB, ELISA
• Clone: 1G6
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Unconjugated
• Format: Azide and BSA Free

MAP4K1 Antibody (1G6) - Azide and BSA Free Summary

• Description: Novus Biologicals Mouse MAP4K1 Antibody (1G6) - Azide and BSA Free (H00011184-M02-100ug) is a monoclonal antibody validated for use in WB and ELISA. All Novus Biologicals antibodies are covered by our 100% guarantee.
• Immunogen: MAP4K1 (NP_009112, 278 a.a. ~ 377 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. GLNRGLILDLLDKLKNPGKGPSIGDIEDEEPELPPAIPRRIRSTHRSSSLGIPDADCCRRHMEFRKLRGMETRPPANTARLQPPRDLRSSSPRKQLSESS
• Isotype: IgG1 Kappa
• Clonality: Monoclonal
• Host: Mouse
• Gene: MAP4K1
• Purity: Protein A or G purified

Applications/Dilutions

• Dilutions:
  • ELISA
  • Western Blot

Packaging, Storage & Formulations

• Storage: Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
• Buffer: In 1x PBS, pH 7.4
• Preservative: No Preservative
• Purity: Protein A or G purified

Notes

This product is produced by and distributed for Abnova, a company based in Taiwan.

Alternate Names for MAP4K1 Antibody (1G6) - Azide and BSA Free

• EC 2.7.11
• EC 2.7.11.1
• Hematopoietic progenitor kinase
• HPK1hematopoietic progenitor kinase 1
• MAPK/ERK kinase kinase kinase 1
• MEK kinase kinase 1
• MEKKK 1
• mitogen-activated protein kinase kinase kinase kinase 1

Background

The hematopoietic progenitor kinase 1 (HPK1) is a mammalian hematopoiesis-specific Ste20 homologue belonging to the germinal center (GC) kinase family, which contains at least 20 kinases (1). HPK1 is implicated in a variety of signaling systems, including epidermal growth factor, transforming growth factor-beta, erythropoietin, prostaglandin E2, and T cell receptor and B cell receptor stimulation. HPK1 is also involved in Fas ligation-mediated apoptosis, NF-B activation and a highly specific activator of the JNK/SAP signaling pathway (2-5). Phosphorylation of HPK1 on threonine 165, serine 171 and tyrosine 379 is a prerequisite for its enzymatic activation in response to immunoreceptor stimulation (6).

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: MAP4K1
• Entrez:
  • 11184(Human)
• OMIM:
  • 601983(Human)
• Uniprot:
  • NP_009112(Human)