MAP4K1 Products

Description

The hematopoietic progenitor kinase 1 (HPK1) is a mammalian hematopoiesis-specific Ste20 homologue belonging to the germinal center (GC) kinase family, which contains at least 20 kinases (1). HPK1 is implicated in a variety of signaling systems, including epidermal growth factor, transforming growth factor-beta, erythropoietin, prostaglandin E2, and T cell receptor and B cell receptor stimulation. HPK1 is also involved in Fas ligation-mediated apoptosis, NF-B activation and a highly specific activator of the JNK/SAP signaling pathway (2-5). Phosphorylation of HPK1 on threonine 165, serine 171 and tyrosine 379 is a prerequisite for its enzymatic activation in response to immunoreceptor stimulation (6).

Bioinformatics

Entrez	11184 Human
Uniprot	AAI52995.1 Human NP_009112 Human NP_009112. Human Q92918 Human
Product By Gene ID	11184
Alternate Names	EC 2.7.11 EC 2.7.11.1 Hematopoietic progenitor kinase HPK1hematopoietic progenitor kinase 1 MAPK/ERK kinase kinase kinase 1 MEK kinase kinase 1 MEKKK 1 mitogen-activated protein kinase kinase kinase kinase 1

Research Areas for MAP4K1

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Phospho-Specific
Protein Kinase