MAP4K1 Products

Antibodies
MAP4K1 Antibody
MAP4K1 Antibody
NBP1-83221
Species: Hu
Applications: IHC, IHC-P
Host: Rabbit Polyclonal
MAP4K1 Antibody
MAP4K1 Antibody
NBP1-31000
Species: Hu, Bovine
Applications: WB, IHC, IHC-P
Host: Rabbit Polyclonal
MAP4K1 Antibody
MAP4K1 Antibody
NB100-1045
Species: Hu
Applications: WB, PEP-ELISA
Host: Goat Polyclonal
Lysates
MAP4K1 Overexpression Lysate ...
MAP4K1 Overexpression Lysate (Native)
NBP2-07520
Applications: WB
Proteins
MAP4K1 Partial Recombinant Pr ...
MAP4K1 Partial Recombinant Protein
H00011184-Q01
Species: Hu
Applications: WB, ELISA, PA
MAP4K1 Recombinant Protein An ...
MAP4K1 Recombinant Protein Antigen
NBP1-83221PEP
Species: Hu
Applications: AC
RNAi
MAP4K1 RNAi
MAP4K1 RNAi
H00011184-R02
Species: Hu

Description

The hematopoietic progenitor kinase 1 (HPK1) is a mammalian hematopoiesis-specific Ste20 homologue belonging to the germinal center (GC) kinase family, which contains at least 20 kinases (1). HPK1 is implicated in a variety of signaling systems, including epidermal growth factor, transforming growth factor-beta, erythropoietin, prostaglandin E2, and T cell receptor and B cell receptor stimulation. HPK1 is also involved in Fas ligation-mediated apoptosis, NF-B activation and a highly specific activator of the JNK/SAP signaling pathway (2-5). Phosphorylation of HPK1 on threonine 165, serine 171 and tyrosine 379 is a prerequisite for its enzymatic activation in response to immunoreceptor stimulation (6).

Bioinformatics

Entrez Human
Uniprot Human
Human
Human
Human
Product By Gene ID 11184
Alternate Names
  • MEKKK 1
  • EC 2.7.11
  • MEK kinase kinase 1
  • Hematopoietic progenitor kinase
  • MAPK/ERK kinase kinase kinase 1
  • HPK1hematopoietic progenitor kinase 1
  • EC 2.7.11.1
  • mitogen-activated protein kinase kinase kinase kinase 1

Pathways for MAP4K1

View related products by pathway and learn more about each of the pathways below.

Programmed Cell Death
Cell Death
Cell Migration
Cell Proliferation
Cell Cycle
T Cell Proliferation
Cell Development
Oncogenesis

Research Areas for MAP4K1

Find related products by research area and learn more about each of the different research areas below.

Phospho-Specific
Protein Kinase

PTMs for MAP4K1

Learn more about PTMs related to MAP4K1.

Phosphorylation
Cleavage
Methylation
Ubiquitination

Bioinformatics Tool for MAP4K1

Discover related pathways, diseases and genes to MAP4K1. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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