MAdCAM-1 Antibody (CA 102.2C1) - Azide and BSA Free

• Reactivity: Hu
• Applications: WB, ELISA, Func
• Clone: CA 102.2C1
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Unconjugated
• Format: Azide and BSA Free
• Concentration: 1.0 mg/ml

MAdCAM-1 Antibody (CA 102.2C1) - Azide and BSA Free Summary

• Description: Novus Biologicals Mouse MAdCAM-1 Antibody (CA 102.2C1) - Azide and BSA Free (NB100-63277) is a monoclonal antibody validated for use in WB and ELISA. All Novus Biologicals antibodies are covered by our 100% guarantee.
• Immunogen: Bacterially expressed human MAdCAM-1
• Localization: Membrane; single pass type I membrane protein.
• Specificity: NB100-63277 recognizes human MAdCAM-1 (mucosal addressin cell adhesion molecule -1), a 40kD protein expressed by vascular endothelium. Clone CA102.2C1 has been reported to block the binding of human cells expressing alpha4 Beta7 to immobilized MAdCAM-1 in vitro.
• Isotype: IgG1
• Clonality: Monoclonal
• Host: Mouse
• Gene: MADCAM1
• Purity: Protein A purified

Applications/Dilutions

• Dilutions:
  • ELISA 1:100-1:2000
  • Functional
  • Western Blot 1:100-1:2000

Packaging, Storage & Formulations

• Storage: Store at -20C. Avoid freeze-thaw cycles.
• Buffer: PBS
• Preservative: No Preservative
• Concentration: 1.0 mg/ml
• Purity: Protein A purified

Alternate Names for MAdCAM-1 Antibody (CA 102.2C1) - Azide and BSA Free

• hMAdCAM-1
• MACAM1
• MAdCAM1
• MAdCAM-1
• mucosal addressin cell adhesion molecule 1
• mucosal addressin cell adhesion molecule-1
• mucosal vascular addressin cell adhesion molecule 1

Background

The protein encoded by this gene is an endothelial cell adhesion molecule that interacts preferentially with the leukocyte beta7 integrin LPAM1 (alpha4 beta7), L selectin, and VLA4 (alpha4 beta1) on myeloid cells to direct leukocytes into mucosal and inflamed tissues. It is a member of the immunoglobulin family and is similar to ICAM1 and VCAM1. At least seven alternatively spliced transcripts encoding different protein isoforms have been found for this gene, but the full length nature of some variants has not been determined.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: MADCAM1
• Entrez:
  • 8174(Human)
• Uniprot:
  • Q13477()
  • Q13477()