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Mucosal vascular addressin-1 (MAdCAM-1) is a type I transmembrane glycoprotein expressed at high levels on high endothelial venules (HEV) of Peyer's patches and mesenteric lymph nodes, and on flat walled venules within the gut lamina propria. It is also expressed on sinus-lining cells in the spleen. (1-3) The countereceptor or "homing receptor" for MAdCAM-1 is alpha4beta7 integrin (also known as LPAM-1). MAdCAM-1 is also a facultative ligand for CD62L/L-selectin. (4, 5) The monoclonal antibody MECA-367 binds to the first domain of MAdCAM-1 and blocks MAdCAM-1-dependent binding in vitro and lymphocyte homing to Peyer's patch HEV in vivo. (1, 2, 4)
![Western Blot MAdCAM-1 Antibody [Unconjugated]](http://images.novusbio.com/fullsize/antibody/MAdCAM1_AF993_Western_Blot_17234.jpg)
![Immunohistochemistry MAdCAM-1 Antibody [Unconjugated]](http://images.novusbio.com/fullsize/antibody/MAdCAM-1_AF993_Immunohistochemistry_7223.jpg)
![Western Blot MAdCAM-1 Antibody (683715) [Unconjugated]](http://images.novusbio.com/fullsize/antibody/mab6056_human-madcam-1-mab-clone-683715-western-blot-1182021114949.jpg)
![Flow Cytometry MAdCAM-1 Antibody (683715) [Unconjugated]](http://images.novusbio.com/fullsize/antibody/MAdCAM-1_MAB6056_Flow_Cytometry_11194.jpg)
![N/A MAdCAM-1 [Biotin]](http://images.novusbio.com/fullsize/elisa/DATA_MAdCAM1_DY2768_ELISA_1884.jpg)
![N/A MAdCAM-1 [Biotin]](http://images.novusbio.com/fullsize/elisa/DATA_MAdCAM1_DY605605_ELISA_2487.jpg)
![Binding Activity MAdCAM-1 [Biotin]](http://images.novusbio.com/fullsize/avi11379_recombinant-human-madcam-1-fc-chimera-avi-tag-protein-cf-binding-activity-45202314853..jpg)
![SDS-Page MAdCAM-1 [Biotin]](http://images.novusbio.com/fullsize/avi11379_recombinant-human-madcam-1-fc-chimera-avi-tag-protein-cf-sds-page-452023145127..jpg)