Lysine (K)-specific Demethylase 4C/KDM4C/JMJD2C Antibody [Alexa Fluor™ Plus 555]

• Reactivity: Hu, Mu
• Applications: WB, IP, ChIP
• Clonality: Polyclonal
• Host: Rabbit
• Conjugate: Alexa Fluor Plus 555

Lysine (K)-specific Demethylase 4C/KDM4C/JMJD2C Antibody [Alexa Fluor™ Plus 555] Summary

• Immunogen: The immunogen recognized by this antibody maps to a region between residue 475 and 525 of human Jumonji Domain Containing 2C using the numbering given in entry NP_055876.2
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: KDM4C
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Chromatin Immunoprecipitation (ChIP)
  • Immunoprecipitation
  • Western Blot
• Application Notes: Optimal dilution of this antibody should be experimentally determined.

Reactivity Notes

Use in Mouse reported in scientific literature (PMID:33441614)

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: 50mM Sodium Borate
• Preservative: 0.05% Sodium Azide
• Purity: Immunogen affinity purified

Notes

This product is provided under an intellectual property license from Life Technologies Corporation. The transfer of this product is conditioned on the buyer using the purchased product solely in research conducted by the buyer, excluding contract research or any fee for service research, and the buyer must not (1) use this product or its components for (a) diagnostic, therapeutic or prophylactic purposes; (b) testing, analysis or screening services, or information in return for compensation on a per-test basis; or (c) manufacturing or quality assurance or quality control, and/or (2) sell or transfer this product or its components for resale, whether or not resold for use in research. For information on purchasing a license to this product for purposes other than as described above, contact Life Technologies Corporation, 5781 Van Allen Way, Carlsbad, CA 92008 USA or outlicensing@thermofisher.com. This conjugate is made on demand. Actual recovery may vary from the stated volume of this product. The volume will be greater than or equal to the unit size stated on the datasheet.

Alternate Names for Lysine (K)-specific Demethylase 4C/KDM4C/JMJD2C Antibody [Alexa Fluor™ Plus 555]

• EC 1.14.11
• EC 1.14.11.-
• GASC-1 protein
• GASC1
• GASC1JmjC domain-containing histone demethylation protein 3C
• Gene amplified in squamous cell carcinoma 1 protein
• JHDM3C
• JMJD2C
• JMJD2CbA146B14.1
• jumonji domain containing 2C
• Jumonji domain-containing protein 2C
• KDM4C
• KIAA0780FLJ25949
• Lysine (K)specific Demethylase 4C
• Lysine (K)-specific Demethylase 4C
• lysine-specific demethylase 4C

Background

JMJD2C is a member of the Jumonji domain 2 (JMJD2) family and encodes a protein with one JmjC domain, one JmjN domain, two PHD-type zinc fingers, and two Tudor domains. This nuclear protein functions as a trimethylation-specific demethylase, converting specific trimethylated histone residues to the dimethylated form. Chromosomal aberrations and increased transcriptional expression of this gene are associated with esophageal squamous cell carcinoma.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: KDM4C