Immunohistochemistry: Lubricin/PRG4 Antibody [NBP1-19048] - Sections of the tibial articular cartilage of 12-week-old normal Mig-6-flox (C) and Mig-6-flox; Prx1Cre conditional knockout (Mig-6-cko) knees (D) ...read more
Immunohistochemistry: Lubricin/PRG4 Antibody [NBP1-19048] - Sections of six-week old tibial articular cartilage of normal Mig-6-flox (M) and Mig-6-cko (N) joints immunostained with antibodies against superficial zone ...read more
Lubricin is a glycoprotein encoded by the PRG4 gene. It has been identified as a component of joint lubrication and synovial homeostasis by reducing friction in joints and preventing synovial cell overgrowth. It is a large, water soluble molecule that acts as a carrier for insoluble surface-active phospholipid (SAPL). Depletion of lubricin function has been associated with camptodactyly-arthropathy-coxa vara-pericarditis syndrome (CACP), an arthritic-like autosomal recessive disorder.
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
FAQs for Lubricin/PRG4 Antibody (NBP1-19048). (Showing 1 - 1 of 1 FAQs).
Can I use the Proteoglycan 4 Antibody NBP1-19048 in rats tissues paraffined?
This antibody has not been tested for use in rat, however I have checked the percentage homology between the rat protein and the human protein and it is 96%. If you would be interested in testing this novel species, please take a look at our Innovators Reward Program.
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