LRIG1 Antibody [Unconjugated]


Western blot shows lysates of bEnd.3 mouse endothelioma cell line untreated (-), treated (+) or mock treated (m) with 30 pmol mouse LRIG1 or mouse ERK1 siRNA. PVDF membrane was probed with 2 µg/mL of Goat Anti-Mouse more
bEnd.3 mouse endothelioma cell line was stained with Goat Anti-Mouse LRIG1 Antigen Affinity‑purified Polyclonal Antibody (Catalog # AF3688, filled histogram) or control antibody (Catalog # AB-108-C, open histogram), more
LRIG1 was detected in immersion fixed bEnd.3 mouse endothelioma cell line using Goat Anti-Mouse LRIG1 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF3688) at 10 µg/mL for 3 hours at room temperature. Cells more

Product Details

Reactivity MuSpecies Glossary
Applications WB, Flow, CyTOF-ready, ICC/IF

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LRIG1 Antibody [Unconjugated] Summary

Mouse myeloma cell line NS0-derived recombinant mouse LRIG1
Accession # P70193
Detects mouse LRIG1 in direct ELISAs and Western blots. In direct ELISAs, less than 10% cross-reactivity with recombinant human (rh) LRIG1 is observed and less than 5% cross-reactivity with rhLRIG3 is observed.
Immunogen affinity purified
Purity Statement
Antigen Affinity-purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.


  • CyTOF-ready
  • Flow Cytometry 0.25 ug/10^6 cells
  • Immunocytochemistry 5-15 ug/mL
  • Western Blot 2 ug/mL
Read Publications using
AF3688 in the following applications:

Packaging, Storage & Formulations

Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
No Preservative
Immunogen affinity purified
Reconstitution Instructions
Reconstitute at 0.2 mg/mL in sterile PBS.


This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for LRIG1 Antibody [Unconjugated]

  • D6Bwg0781e
  • Img
  • LIG1
  • LIG-1
  • LRIG1


LRIG-1 (leucine-rich repeats and Ig-like domains-1; also LIG-1) is an approximately 130-145 kDa glycoprotein that belongs to the LRIG gene family.  It is widely expressed, and appears on the surface of prostatic epithelium, endothelial cells, vascular and visceral smooth muscle, mammary epithelium, cardiac muscle, keratinocytes and neurons.  LRIG-1 is believed to negatively regulate the ErbB family of receptors.  In particular, and in a ligand-independent manner, LRIG-1 complexes with all four ErbBs, promoting their ubiquitination and decreasing their number.  Alternatively, LRIG-1 is suggested to bind to the ErbBs, preventing their dimerization and signal transduction.  Mature mouse LRIG-1 is a 1057 amino acid (aa) type I transmembrane protein (SwissProt #:P70193).  It contains a large 762 amino acid (aa) extracellular domain (ECD) (aa 35-795) plus a 274 aa cytoplasmic region.  The ECD contains 17 LRRs (aa’s 35-491) and three C2-type Ig-like domains (aa’s 497-781).  These two domain types are each sufficient for EGFR binding.  There one potential alternative splice form that a deletion of aa 875-923.  The LRIG-1 ECD undergoes proteolysis, generating 90-105 and 60-70 kDa soluble fragments.  Over aa 37-794, human LRIG-1 shares 97% and 90% aa sequence identity with rat and human LRIG-1, respectively.


This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for LRIG1 Antibody (AF3688)(24)

We have publications tested in 1 confirmed species: Mouse.

We have publications tested in 6 applications: Flow Cytometry, ICC, IF, IHC, IHC-Fr, IHC-P.

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Showing Publications 1 - 10 of 24. Show All 24 Publications.
Publications using AF3688 Applications Species
AE Lewis, A Kuwahara, J Franzosi, JO Bush Tracheal separation is driven by NKX2-1-mediated repression of Efnb2 and regulation of endodermal cell sorting Cell Reports, 2022-03-15;38(11):110510. 2022-03-15 [PMID: 35294885] (IF, Mouse) IF Mouse
J Bhuju, KM Olesen, CS Muenyi, TS Patel, RW Read, L Thompson, O Skalli, Q Zheng, EA Grice, CH Sutter, TR Sutter Cutaneous Effects of In Utero and Lactational Exposure of C57BL/6J Mice to 2,3,7,8-Tetrachlorodibenzo-p-dioxin Toxics, 2021-08-20;9(8):. 2021-08-20 [PMID: 34437510] (IHC, Mouse) IHC Mouse
S Huang, P Kuri, Y Aubert, M Brewster, N Li, O Farrelly, G Rice, H Bae, S Prouty, T Dentchev, W Luo, BC Capell, P Rompolas Lgr6 marks epidermal stem cells with a nerve-dependent role in wound re-epithelialization Cell Stem Cell, 2021-06-07;0(0):. 2021-06-07 [PMID: 34102139] (IHC, Mouse) IHC Mouse
D Jeong, D Lozano Cas, A Gengathara, K Edwards, A Saghatelya, DR Kaplan, FD Miller, SA Yuzwa LRIG1-Mediated Inhibition of EGF Receptor Signaling Regulates Neural Precursor Cell Proliferation in the Neocortex Cell Rep, 2020-10-13;33(2):108257. 2020-10-13 [PMID: 33053360] (ICC, IHC, Mouse) ICC, IHC Mouse
A Kuwahara, AE Lewis, C Coombes, FS Leung, M Percharde, JO Bush Delineating the early transcriptional specification of the mammalian trachea and esophagus Elife, 2020-06-09;9(0):. 2020-06-09 [PMID: 32515350] (IHC, Mouse) IHC Mouse
G Piedrafita, V Kostiou, A Wabik, B Colom, D Fernandez-, A Herms, K Murai, BA Hall, PH Jones A single-progenitor model as the unifying paradigm of epidermal and esophageal epithelial maintenance in mice Nat Commun, 2020-03-18;11(1):1429. 2020-03-18 [PMID: 32188860] (IHC, Mouse) IHC Mouse
Y Ge, Y Miao, S Gur-Cohen, N Gomez, H Yang, M Nikolova, L Polak, Y Hu, A Verma, O Elemento, JG Krueger, E Fuchs The aging skin microenvironment dictates stem cell behavior Proc. Natl. Acad. Sci. U.S.A., 2020-02-24;0(0):. 2020-02-24 [PMID: 32094197] (IHC, Mouse) IHC Mouse
K Murai, G Skrupskely, G Piedrafita, M Hall, V Kostiou, SH Ong, T Nagy, A Cagan, D Goulding, AM Klein, BA Hall, PH Jones Epidermal Tissue Adapts to Restrain Progenitors Carrying Clonal p53 Mutations Cell Stem Cell, 2018-09-27;0(0):. 2018-09-27 [PMID: 30269904] (IHC, Mouse) IHC Mouse
K Singh, E Camera, L Krug, A Basu, RK Pandey, S Munir, M Wlaschek, S Kochanek, M Schorpp-Ki, M Picardo, P Angel, C Niemann, P Maity, K Scharffett JunB defines functional and structural integrity of the epidermo-pilosebaceous unit in the skin Nat Commun, 2018-08-24;9(1):3425. 2018-08-24 [PMID: 30143626] (IHC-P, Mouse) IHC-P Mouse
S Yui, L Azzolin, M Maimets, MT Pedersen, RP Fordham, SL Hansen, HL Larsen, J Guiu, MRP Alves, CF Rundsten, JV Johansen, Y Li, CD Madsen, T Nakamura, M Watanabe, OH Nielsen, PJ Schweiger, S Piccolo, KB Jensen YAP/TAZ-Dependent Reprogramming of Colonic Epithelium Links ECM Remodeling to Tissue Regeneration Cell Stem Cell, 2017-12-14;22(1):35-49.e7. 2017-12-14 [PMID: 29249464] (IHC, Mouse) IHC Mouse
Show All 24 Publications.

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Gene Symbol Lrig1