LOX propeptide Antibody [DyLight 405]


There are currently no images for LOX propeptide Antibody (NB110-41568V).

Every product we sell is backed by Novus' 100% Guarantee. If you have used this product, please submit your images and reviews to earn reward points.

Product Details

Reactivity Hu, Mu, Rt, Po, PmSpecies Glossary
Applications WB, ICC/IF, IHC, IHC-P
DyLight 405

LOX propeptide Antibody [DyLight 405] Summary

A synthetic peptide made to an internal region of mouse LOX propeptide (residues 78-115). [UniProt# P28301]
This antibody specifically recognizes both the pro-enzyme and pro-peptide forms of LOX protein in mouse and rat.
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.


  • Western Blot
  • Immunocytochemistry/Immunofluorescence
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin
Application Notes
This LOX propeptide antibody is useful for Immunocytochemistry/Immunofluorescence, Immunohistochemistry-Paraffin and Western Blot where a band is seen at ~18 kDa. The strong band at 50 kDa and smear of bands that run between 46 kDa and 50 kDa are glycosylated and non-glycosylated forms of pro-lysyl oxidase. Bands between 28-36 kDa are glycosylated propeptide. The variation in MW depends on the extent of glycosylation.

Reactivity Notes

Human, mouse, rat, primate, and pig.

Packaging, Storage & Formulations

Store at 4C in the dark.
50mM Sodium Borate
0.05% Sodium Azide
Immunogen affinity purified


Dylight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries. This conjugate is made on demand. Actual recovery may vary from the stated volume of this product. The volume will be greater than or equal to the unit size stated on the datasheet.

Alternate Names for LOX propeptide Antibody [DyLight 405]

  • lysyl oxidaseEC
  • MGC105112
  • protein-lysine 6-oxidase


Lysyl oxidase (LOX) is a critical enzyme in extracellular matrix biosynthesis as well as in the maintainance of normal bone phenotype. It is synthesized/secreted as a 50-kD proenzyme 'pro-LOX' which is then processed to 30-kD mature enzyme 'LOX' and 18-kD lysyl oxidase propeptide 'LOX-PP' by extracellular procollagen C-proteinases (BMP1, Tll1, and Tll2). LOX-PP has been proposed to implicate in the maintenance of inactive state of LOX within the secretory pathway and to act as intramolecular chaperones which facilitate the accurate protein folding/targeting to correct destinations. LOX-PP involves tumor suppression by inhibiting RAS-dependent cellular transformation and its expression has also been associated with inhibition of anchorage-independent progression as well as migration and growth suppression xenografts in Her-2/neu-driven breast cancer. LOX-PP also inhibits PI3K/AKT and ERK1/2 MAP kinase pathways, as well as the levels of downstream NF-kB/cyclin D1 signals in certain cancers - breast, pancreatic, lung, prostate and oral cancers. LOX-PP has also been shown to inhibit DNA synthesis in rat's VSMCs cultures, osteoblast proliferation and FGF-2 signaling.


This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Customers Who Viewed This Item Also Viewed...

Species: Hu, Po, Ca, Fe, Gt, GP, Sh
Applications: WB, IHC, IHC-P
Species: Hu, Mu
Applications: WB, ICC/IF, IHC, IHC-P
Species: Hu
Applications: WB, ELISA, Flow, ICC/IF
Species: Hu
Species: Hu, Mu
Applications: WB, Simple Western, ICC/IF
Species: Hu, Rt, Ca, Mk, Pm
Applications: WB, ICC/IF, IHC, IHC-P
Species: Hu
Applications: IHC, IHC-P
Species: Hu, Mu, Rt
Applications: WB, Simple Western, IHC, IHC-P
Species: Hu
Applications: WB, Flow, ICC/IF, IHC, IHC-P
Species: Hu, Mu
Applications: WB, ICC/IF, IHC, IHC-P
Species: Hu
Applications: WB, ICC/IF, IP
Species: Hu, Mu
Applications: WB, Simple Western, ICC/IF
Species: Hu
Applications: WB, IP, ICC
Species: Hu, Mu, Rt, Bv
Applications: WB, IHC, IHC-P
Species: Hu, Mu, Rt
Applications: WB, ICC/IF, IHC
Species: Hu, Mu, Rt, Po, Pm
Applications: WB, ICC/IF, IHC, IHC-P

Publications for LOX propeptide Antibody (NB110-41568V) (0)

There are no publications for LOX propeptide Antibody (NB110-41568V).
By submitting your publication information earn gift cards and discounts for future purchases.

Reviews for LOX propeptide Antibody (NB110-41568V) (0)

There are no reviews for LOX propeptide Antibody (NB110-41568V). By submitting a review you will receive an Amazon e-Gift Card or Novus Product Discount.
  • Review with no image -- $10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen
  • Review with an image -- $25/€18/£15/$25 CAD/¥150 Yuan/¥2500 Yen
  • 1st to review with an image -- $50/€35/£30/$50 CAD/¥300 Yuan/¥5000 Yen

Product General Protocols

Find general support by application which include: protocols, troubleshooting, illustrated assays, videos and webinars.

Video Protocols

WB Video Protocol
ICC/IF Video Protocol

FAQs for LOX propeptide Antibody (NB110-41568V) (0)

There are no specific FAQs related to this product. Read our general customer & technical service FAQs.

Secondary Antibodies


Isotype Controls

Additional LOX propeptide Products

Bioinformatics Tool for LOX propeptide Antibody (NB110-41568V)

Discover related pathways, diseases and genes to LOX propeptide Antibody (NB110-41568V). Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
Visit Tool

Diseases for LOX propeptide Antibody (NB110-41568V)

Discover more about diseases related to LOX propeptide Antibody (NB110-41568V).

Pathways for LOX propeptide Antibody (NB110-41568V)

View related products by pathway.

PTMs for LOX propeptide Antibody (NB110-41568V)

Learn more about PTMs related to LOX propeptide Antibody (NB110-41568V).

Research Areas for LOX propeptide Antibody (NB110-41568V)

Find related products by research area.

Blogs on LOX propeptide.

LOX propeptide: A novel peptide cancer therapeutic
Lysyl oxidase, also known as LOX, is a copper-dependent enzyme that cross-links collagen and elastin through the oxidative deamination of peptidyl lysine (collagen and elastin) and hydroxylysine (collagen only) residues, thereby playing a critical rol...  Read full blog post.

Customers Who Bought This Also Bought

COX-2 Antibody

Contact Information

Product PDFs


Concentration Calculator

The concentration calculator allows you to quickly calculate the volume, mass or concentration of your vial. Simply enter your mass, volume, or concentration values for your reagent and the calculator will determine the rest.


Review this Product

Be the first to review our LOX propeptide Antibody [DyLight 405] and receive a gift card or discount.


Gene Symbol LOX