LMP2/PSMB9 Antibody (792520) [Alexa Fluor™ Plus 647]

• Reactivity: Hu
• Clone: 792520
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor Plus 647

LMP2/PSMB9 Antibody (792520) [Alexa Fluor™ Plus 647] Summary

• Specificity: Detects human LMP2/PSMB9 in direct ELISAs and Western blots. In direct ELISAs, approximately 50% cross-reactivity with recombinant human PSMB6 is observed.
• Isotype: IgG2b
• Clonality: Monoclonal
• Host: Mouse

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for LMP2/PSMB9 Antibody (792520) [Alexa Fluor™ Plus 647]

• beta1i
• LMP2
• LMP2MGC70470
• Low molecular mass protein 2
• Macropain chain 7
• Multicatalytic endopeptidase complex chain 7
• proteasome (prosome, macropain) subunit, beta type, 9 (large multifunctionalpeptidase 2)
• proteasome catalytic subunit 1i
• Proteasome chain 7
• proteasome subunit beta 6i
• proteasome subunit beta type-9
• Proteasome subunit beta-1i
• proteasome-related gene 2
• PSMB6iproteasome (prosome, macropain) subunit, beta type, 9 (large multifunctionalprotease 2)
• PSMB9
• Really interesting new gene 12 protein
• RING12
• RING12EC 3.4.25.1

Background

LMP2 (large multifunctional peptidase 2), also called PSMB9 (proteasome subunit beta 9) or PSMB6i, is a 22 kDa broad-specificity aminopeptidase of the T1B family that is a component of the 20S immunoproteasome core (a7b7b7a7) of the 26S proteasome particle. Induction of LMP2 by IFN-g, IRF-1, TNF-a, CD40L, or heat shock in immune-responsive cells or cancer cells promotes replacement of proteasome subunit PSMB6 by LMP2 and processing of peptides for presentation by MHC I. After auto-cleavage between amino acids (aa) 20-21, human LMP2 (aa 21-219) shares 91% aa sequence identity with mouse and rat LMP2. Alternate splicing creates a short form, LMP2.S, which lacks aa 4-13 within the propeptide.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.