LMP2/PSMB9 Products

Antibodies
LMP2/PSMB9 Antibody (1D1)
LMP2/PSMB9 Antibody (1D1)
Species: Hu, Mk
Applications: WB, Flow, ICC/IF, IHC, IHC-P
Host: Mouse Monoclonal
LMP2/PSMB9 Antibody
LMP2/PSMB9 Antibody
NBP2-33681
Species: Hu, Rat
Applications: WB, ICC/IF, IHC, IHC-P
Host: Rabbit Polyclonal
LMP2/PSMB9 Antibody (792520)
LMP2/PSMB9 Antibody (792520)
MAB7709
Species: Hu
Applications: WB, ICC
Host: Mouse Monoclonal
Lysates
LMP2/PSMB9 Overexpression Lys ...
LMP2/PSMB9 Overexpression Lysate (...
NBL1-14885
Applications: WB
Proteins
LMP2/PSMB9 Recombinant Protei ...
LMP2/PSMB9 Recombinant Protein Ant...
NBP2-33681PEP
Species: Hu
Applications: AC
LMP2/PSMB9 Recombinant Protei ...
LMP2/PSMB9 Recombinant Protein
NBP1-51067
Applications: PAGE
RNAi
LMP2/PSMB9 RNAi
LMP2/PSMB9 RNAi
H00005698-R02
Species: Hu
LMP2/PSMB9 RNAi
LMP2/PSMB9 RNAi
H00005698-R01
Species: Hu

Description

Proteolytic degradation is critical to the maintenance of appropriate levels of short-lived and regulatory proteins as important and diverse as those involved in cellular metabolism, heat shock and stress response, antigen presentation, modulation of cell surface receptors and ion channels, cell cycle regulation, transcription, and signalling factors. The ubiquitin-proteasome pathway deconstructs most proteins in the eukaryotic cell cytosol and nucleus. Other proteins are degraded via the vacuolar pathway which includes endosomes, lysosomes, and the endoplasmic reticulum. The 26S proteasome is an ATP-dependent, multisubunit (~31), barrel-shaped molecular machine with an apparent molecular weight of ~2.5 MDa. It consists of a 20S proteolytic core complex which is crowned at one or both ends by 19S regulatory subunit complexes. The 19S regulatory subunits recognize ubiquitinated proteins and play an essential role in unfolding and translocating targets into the lumen of the 20S subunit. The PA28/11S REG Activator protein complex functions as a proteolytic activator. LMP2 is a catalytic subunit of the 20S proteasome and, upon interferon gamma-induction, replaces the delta subunit. LMP2 alters the specificity of the 20S proteasome and is critical for the production of MHC class I ligands, production of T-lymphocytes, and is suggested to increase the efficiency of antigen presentation of the immune response. Several genetic diseases are associated with defects in the ubiquitin-proteasome pathway. Some examples of affected proteins include those linked to cystic fibrosis (CF transmembrane regulator), Angelman's syndrome (E6-AP), and Liddle syndrome (endothelial sodium channels).

Bioinformatics

Entrez Human
Mouse
Rat
Uniprot Human
Human
Human
Human
Human
Product By Gene ID 5698
Alternate Names
  • proteasome-related gene 2
  • Proteasome subunit beta-1i
  • proteasome subunit beta type-9
  • Proteasome chain 7
  • proteasome subunit beta 6i
  • Multicatalytic endopeptidase complex chain 7
  • proteasome catalytic subunit 1i
  • Macropain chain 7
  • Low molecular mass protein 2
  • beta1i
  • LMP2MGC70470
  • PSMB6iproteasome (prosome, macropain) subunit, beta type, 9 (large multifunctionalprotease 2)
  • RING12EC 3.4.25.1
  • Really interesting new gene 12 protein
  • proteasome (prosome, macropain) subunit, beta type, 9 (large multifunctionalpeptidase 2)

PTMs for LMP2/PSMB9

Learn more about PTMs related to LMP2/PSMB9.

Acetylation
Methylation

Bioinformatics Tool for LMP2/PSMB9

Discover related pathways, diseases and genes to LMP2/PSMB9. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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