LDLR Antibody Blocking Peptide

• Reactivity: Hu
• Applications: AC
• Concentration: 1.0 mg/ml

LDLR Antibody Blocking Peptide Summary

• Description: A LDLR antibody blocking peptide.
• Immunogen: Synthetic peptide made to an internal portion of the human protein (within residues 500-550). [Swiss-Prot# P01130]
• Localization: Membrane; Single-pass type I membrane protein. Membrane ? clathrin-coated pit; Single-pass type I membrane protein.
• Protein/Peptide Type: Antibody Blocking Peptide
• Gene: LDLR
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Antibody Competition
• Application Notes: This peptide is useful as a blocking peptide for NBP1-06709. For further blocking peptide related protocol, click here. This peptide is useful as a negative control for Western blot.

Packaging, Storage & Formulations

• Storage: Store at -80C. Avoid freeze-thaw cycles.
• Buffer: PBS, 30% glycerol
• Preservative: 0.1% Sodium Azide
• Concentration: 1.0 mg/ml
• Purity: Immunogen affinity purified

Alternate Names for LDLR Antibody Blocking Peptide

• FH
• FHC
• LDL R
• LDL receptor
• LDLCQ2
• LDLR
• low density lipoprotein receptor
• low-density lipoprotein receptor class A domain-containing protein 3
• low-density lipoprotein receptor

Background

The low density lipoprotein (LDL) receptor system coordinates the metabolism of cholesterol, an essential component of the plasma membrane of all mammalian cells. Study of this system has led to an enhanced understanding of the cellular basis of cholesterol homeostasis. It has also brought into focus an important mechanism of metabolic regulation--the process of receptor-mediated endocytosis (1). Data suggest that the juxtamembranous region of the cytoplasmic domain participates in protein:protein interactions that allow the low density lipoprotein receptor to cluster in coated pits (2). It has been shown that the family of LDL receptors may serve as viral receptors. Endocytosis of the Flaviviridae viruses, hepatitis C virus, GB virus C/hepatitis G virus, and bovine viral diarrheal virus (BVDV) was shown to be mediated by LDL receptors on cultured cells (3).

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Peptides and proteins are guaranteed for 3 months from date of receipt.

Review for LDLR Protein (NBP1-06709PEP) (1)

Average Rating: 5

(Based on 1 review)

reviewed by: Verified Customer antibody (NBP1-06709) blocking test with Peptide (NBP1-06709pep) 03/17/2025

Summary

• Application: Other
• Lot: A-4

Bioinformatics

• Gene Symbol: LDLR