LCoR Antibody (731229) [Alexa Fluor® 647]

• Reactivity: Hu
• Applications: ICC/IF
• Clone: 731229
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor 647

LCoR Antibody (731229) [Alexa Fluor® 647] Summary

• Immunogen: E. coli-derived recombinant human LCoR
  Asn110-Gln338
  Accession # Q96JN0
• Specificity: Detects human LCoR in direct ELISAs.
• Isotype: IgG2b
• Clonality: Monoclonal
• Host: Mouse
• Purity Statement: Protein A or G purified

Applications/Dilutions

• Dilutions:
  • Immunocytochemistry

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for LCoR Antibody (731229) [Alexa Fluor® 647]

• FLJ38026
• KIAA1795RP11-175O19.1
• LCoR
• ligand dependent nuclear receptor corepressor
• Mblk1-related protein 2
• MLR2
• MLR2ligand-dependent corepressor

Background

LCoR (ligand-dependent corepressor), also known as MLR2 (Mblk1-related protein 2), is a 47-50 kDa nuclear phosphoprotein that is a corepressor of ligand-dependent transcriptional activation by nuclear receptors such as estrogen and progesterone receptors. It is widely expressed throughout fetal development and in the adult. The 433 amino acid (aa) LCoR contains two N-terminal PxDLS nuclear receptor interaction motifs, a central HDAC interaction motif, a nuclear localization signal, and a C‑terminal Helix-Turn-Helix motif. Alternate splicing produces a truncated 406 aa variant. Within the region used as an immunogen, human LCoR shares 97% aa identity with mouse and rat LCoR.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.