KLF6 Antibody

• Reactivity: Hu
• Applications: WB
• Clonality: Polyclonal
• Host: Sheep
• Conjugate: Unconjugated
• Concentration: LYOPH

KLF6 Antibody Summary

• Immunogen: E. coli-derived recombinant human KLF6
  Met1-Ser109
  Accession # Q99612
• Specificity: Detects human KLF6 in direct ELISAs and Western blots. In direct ELISAs and Western blots, this antibody shows less than 5% cross‑reactivity with rhKLF4, rhKLF5 and rmKLF15.
• Source: N/A
• Isotype: IgG
• Clonality: Polyclonal
• Host: Sheep
• Gene: KLF6
• Purity: Immunogen affinity purified
• Purity Statement: Antigen Affinity-purified

Applications/Dilutions

• Dilutions:
  • Western Blot 0.1 ug/mL

Packaging, Storage & Formulations

• Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
• Buffer: Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
• Preservative: No Preservative
• Concentration: LYOPH
• Purity: Immunogen affinity purified
• Reconstitution Instructions: Reconstitute at 0.2 mg/mL in sterile PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for KLF6 Antibody

• BCD1
• BCD1Zf9
• B-cell-derived protein 1
• COPEB
• COPEBCBA1
• core promoter element binding protein
• Core promoter element-binding protein
• CPBP
• CPBPZF9
• DKFZp686N0199
• EC 2.1.1.43
• EC 6.1.1.15
• GBF
• GC-rich binding factor
• GC-rich sites-binding factor GBF
• KLF6
• Krueppel-like factor 6
• Kruppel-like factor 6
• Kruppel-like zinc finger protein Zf9
• PAC1
• Proto-oncogene BCD1
• protooncogene B-cell derived 1
• ST12
• suppression of tumorigenicity 12 (prostate)
• Suppressor of tumorigenicity 12 protein
• Transcription factor Zf9

Background

KLF6 is a ubiquitously expressed nuclear protein belonging to the Kruppel C2H2-type zinc finger transcription factor family. It is a 283 amino acid (aa) protein that contains an N-terminal acidic domain, a Ser/Thr-rich region and three zinc-finger motifs. The acidic region may interact with other transcription factors. The Ser-Thr-rich region likely serves as an activation domain, and the zinc-finger motifs bind DNA. One alternate splice form is known that shows a 55 aa substitution for the C‑terminal 57 amino acids. KLF6 is considered a tumor-suppressor gene. It also promotes iNOS and TGF-beta 1 expression. Human KLF6 shares 94%, 95% and 94% aa sequence identity with rat, mouse and canine KLF6, respectively.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for KLF6 Antibody (AF3499)(1)

Publication using AF3499

• Donev RM, Gray LC, Sivasankar B, Hughes TR, van den Berg CW, Morgan BP Modulation of CD59 expression by restrictive silencer factor-derived peptides in cancer immunotherapy for neuroblastoma. Cancer Res., 2008-07-15;68(14):5979-87. 2008-07-15 [PMID: 18632654] (Immunoprecipitation, Human)

Bioinformatics

• Gene Symbol: KLF6
• Uniprot:
  • Q99612()