Latent TGF-beta bp4 Antibody [Alexa Fluor® 350]

• Reactivity: Mu
• Applications: WB
• Clonality: Polyclonal
• Host: Goat
• Conjugate: Alexa Fluor 350

Latent TGF-beta bp4 Antibody [Alexa Fluor® 350] Summary

• Immunogen: Mouse myeloma cell line NS0-derived recombinant mouse Latent TGF‑β bp4 isoform 1
  Ser25-Ala1666 (Arg542-Pro547)
  Accession # AAI41006
• Specificity: Detects mouse Latent TGF‑ beta bp4 in direct ELISAs and Western blots. In direct ELISAs and Western blots, less than 1% cross-reactivity with recombinant human (rh) LTBP-1 and rhLTBP-2 is observed.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Goat
• Purity Statement: Antigen Affinity-purified

Applications/Dilutions

• Dilutions:
  • Western Blot

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Latent TGF-beta bp4 Antibody [Alexa Fluor® 350]

• Latent TGFbeta bp4
• Latent TGF-beta bp4
• latent transforming growth factor beta binding protein 4
• LTBP4
• LTBP-4
• LTBP4L
• LTBP4S

Background

LTBP-4 is a 170 kDa extracellular glycoprotein that belongs to the LTBP/fibrillin family. These proteins contain a conserved pattern of eight cysteine residues (8Cys) and EGF-like domains. Mouse LTBP-4 isoform 1 is synthesized as 1666 amino acid residues and contains 14 EGF-like motifs and three 8Cys, the 3^rd of which is responsible for disulfide-association with the latency-linked associated peptide (LAP) of latent TGF-beta 1. LTBP-4 is expressed in multiple tissues and is involved in the assembly, secretion and targeting of latent TGF-beta to sites where it can be activated. Two additional splice isoforms that differ from isoform 1 in residues 60‑150 or 67‑150, have been described. Human and mouse LTBP-4 share 90% amino acid sequence homology.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.