Latent TGF-beta bp1 Antibody (MM0447-5L38) [Janelia Fluor® 669]

• Reactivity: Hu
• Applications: WB, IHC
• Clone: MM0447-5L38
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Janelia Fluor 669

Latent TGF-beta bp1 Antibody (MM0447-5L38) [Janelia Fluor® 669] Summary

• Description: This conjugate is made on demand and is not held in inventory. Each order represents a unique lot. All conjugates are generated using validated conjugation protocols and meet strict degree of labeling (F/P) specifications; additional information is available upon request. The antibody concentration is provided on the individual product label.
  
  For specialized conjugation needs, like large quantities, specific concentrations, and defined F/P ratios, bulk and custom antibody conjugation services are available.
• Immunogen: Human recombinant Latent TGF-beta bp1
• Isotype: IgG1
• Clonality: Monoclonal
• Host: Mouse
• Gene: LTBP1
• Purity: Protein G purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin
  • Western Blot
• Application Notes: Recommended applications are based on validated applications from the unconjugated base product NBP2-11783. This conjugated antibody is not kept in inventory and is made to order using validated conjugation protocols.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: 50mM Sodium Borate
• Preservative: 0.05% Sodium Azide
• Purity: Protein G purified

Notes

Sold under license from the Howard Hughes Medical Institute, Janelia Research Campus.

Alternate Names for Latent TGF-beta bp1 Antibody (MM0447-5L38) [Janelia Fluor® 669]

• Latent TGFbeta bp1
• Latent TGF-beta bp1
• latent transforming growth factor beta binding protein 1
• latent-transforming growth factor beta-binding protein 1
• LTBP1
• LTBP-1
• MGC163161
• TGF-beta1-BP-1
• Transforming growth factor beta-1-binding protein 1

Background

LTBP1, also known as latent-transforming growth factor beta-binding protein 1, consists of five isoforms of sizes 186.8 kDa, 152.9 kDa, 147.2 kDa, 186.9 kDa, and 153 kDa and is involved in directing and regulating the activity of TGFB1. Current research is being conducted on diseases and disorders such as cataracts, fibrosis, geleophysic dysplasia, macular degeneration, aortic aneurysm, malignant glioma, hepatitis, vaginitis, scleroderma, and nephropathy. The protein is involved in extracellular matrix organization, mitochondrial apoptosis, TGF-beta signaling, and GSK3 signaling pathways, where it interacts with FN1, FBN2, TGFB1, ITGB5, and ATN1.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: LTBP1