Reactivity | HuSpecies Glossary |
Applications | WB, ELISA, IHC, IHC-Fr |
Clone | UJ127 |
Clonality | Monoclonal |
Host | Mouse |
Conjugate | HRP |
Immunogen | Homogenous suspension of 16 week human fetal brain |
Localization | Cell surface |
Marker | Axonal Marker |
Specificity | Recognizes a cell surface protein of 220-240kDa, identified as L1 cell adhesion molecule. The L1CAM gene, which is located in Xq28, is involved in three distinct conditions: 1) HSAS (hydrocephalus-stenosis of the aqueduct of Sylvius); 2) MASA (mental retardation, aphasia, shuffling gait, and adducted thumbs); and 3) SPG1 (spastic paraplegia). The L1, neural cell adhesion molecule (L1CAM) also plays an important role in axon growth, fasciculation, and neural migration as well as in mediating neuronal differentiation. Expression of L1 protein is restricted to tissues arising from neuroectoderm. This MAb is useful in the identification of primitive neuroectodermal tumors. It binds to tumors of neuroectodermal and glial origin e.g. neuroblastoma and Schwannomas. It does not bind to pediatric or adult brain. |
Isotype | IgG1 Kappa |
Clonality | Monoclonal |
Host | Mouse |
Gene | L1CAM |
Purity | Protein A purified |
Innovator's Reward | Test in a species/application not listed above to receive a full credit towards a future purchase. |
Dilutions |
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Readout System | |||
Control |
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Storage | Store at 4C in the dark. |
Buffer | PBS |
Preservative | No Preservative |
Purity | Protein A purified |
Secondary Antibodies |
Isotype Controls |
Alexa Fluor 350 | NBP2-34505AF350 | |
Alexa Fluor 405 | NBP2-34505AF405 | |
Alexa Fluor 488 | NBP2-34505AF488 | |
Alexa Fluor 532 | NBP2-34505AF532 | |
Alexa Fluor 594 | NBP2-34505AF594 | |
Alexa Fluor 647 | NBP2-34505AF647 | |
Alexa Fluor 700 | NBP2-34505AF700 | |
Alexa Fluor 750 | NBP2-34505AF750 | |
Allophycocyanin | NBP2-34505APC | |
Biotin | NBP2-34505B | |
DyLight 350 | NBP2-34505UV | |
DyLight 405 | NBP2-34505V | |
DyLight 488 | NBP2-34505G | |
DyLight 550 | NBP2-34505R | |
DyLight 594 | NBP2-34505DL594 | |
DyLight 650 | NBP2-34505C | |
DyLight 680 | NBP2-34505FR | |
DyLight 755 | NBP2-34505IR | |
FITC | NBP2-34505F | |
HRP | NBP2-34505H | |
Janelia Fluor 549 | NBP2-34505JF549 | |
Janelia Fluor 646 | NBP2-34505JF646 | |
PE | NBP2-34505PE | |
PerCP | NBP2-34505PCP |
Diseases for L1CAM Antibody (NBP2-34505H)Discover more about diseases related to L1CAM Antibody (NBP2-34505H).
| Pathways for L1CAM Antibody (NBP2-34505H)View related products by pathway.
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PTMs for L1CAM Antibody (NBP2-34505H)Learn more about PTMs related to L1CAM Antibody (NBP2-34505H).
| Research Areas for L1CAM Antibody (NBP2-34505H)Find related products by research area.
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Identifying tumoral and stromal transcriptomes that underlie tumor plasticity and stromal neuroinflammatory response in brain metastasis By Jamshed Arslan, Pharm. D., PhD. Cancers in the brain often come from tumors elsewhere in the body. Several adaptive mechanisms influence brain metastasis, such as blood brain barrier leakage that can be induced by... Read full blog post. |
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Gene Symbol | L1CAM |