L1CAM Antibody (OTI10C12)

Product Discontinued

L1CAM Antibody (OTI10C12) Summary

• Immunogen: Full length human recombinant protein of human L1CAM (NP_000416) produced in HEK293T cell.
• Marker: Axon Marker
• Specificity: This antibody is specific for Homo sapiens L1 cell adhesion molecule (L1CAM), transcript variant 1.
• Isotype: IgG1
• Clonality: Monoclonal
• Host: Mouse
• Gene: L1CAM
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Flow Cytometry 1:100
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Paraffin 1:50
  • Western Blot 1:500-1000
• Theoretical MW: 140 kDa.
  Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Reactivity Notes

Human

Packaging, Storage & Formulations

• Storage: Store at -20C. Avoid freeze-thaw cycles.
• Buffer: PBS (pH 7.3), 1.0% BSA and 50% Glycerol
• Preservative: 0.02% Sodium Azide
• Purity: Immunogen affinity purified

Alternate Names for L1CAM Antibody (OTI10C12)

• antigen identified by monoclonal R1
• CAML1
• CAML1N-CAML1
• CD171 antigen
• CD171
• HSAS
• HSAS1
• L1 cell adhesion molecule
• L1CAM
• MASA
• MIC5
• N-CAM-L1
• NCAM-L1
• neural cell adhesion molecule L1
• S10
• SPG1

Background

The protein encoded by this gene is an axonal glycoprotein belonging to the immunoglobulin supergene family. The ectodomain, consisting of several immunoglobulin-like domains and fibronectin-like repeats (type III), is linked via a single transmembrane sequence to a conserved cytoplasmic domain. This cell adhesion molecule plays an important role in nervous system development, including neuronal migration and differentiation. Mutations in the gene cause three X-linked neurological syndromes known by the acronym CRASH (corpus callosum hypoplasia, retardation, aphasia, spastic paraplegia and hydrocephalus). Alternative splicing of a neuron-specific exon is thought to be functionally relevant.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: L1CAM
• Entrez:
  • 3897(Human)