KMT3B/NSD1 Antibody

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Immunohistochemistry: KMT3B/NSD1 Antibody [NB100-1744] - Sample: FFPE section of human breast carcinoma. Antibody: Affinity purified rabbit anti-NSD1 used at a dilution of 1:250. Detection: DAB staining using ...read more
Immunohistochemistry: KMT3B/NSD1 Antibody [NB100-1744] - Sample : FFPE section of human prostate adenocarcinoma. Antibody: Affinity purified rabbit anti-NSD1 used at a dilution of 1:250. Detection: DAB

Product Details

Summary
Reactivity HuSpecies Glossary
Applications IHC-P
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated

Order Details

KMT3B/NSD1 Antibody Summary

Immunogen
The immunogen recognized by this antibody maps to a region between residue 650 and 700 of human NSD1 using the numbering given in SwissProt entry Q96L73 (GeneID 64324).
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
NSD1
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Immunohistochemistry-Paraffin 1:100-1:500
Publications
Read Publication using NB100-1744.

Packaging, Storage & Formulations

Storage
Store at 4C. Do not freeze.
Buffer
TBS and 0.1% BSA
Preservative
0.09% Sodium Azide
Purity
Immunogen affinity purified

Alternate Names for KMT3B/NSD1 Antibody

  • Androgen receptor coactivator 267 kDa protein
  • Androgen receptor-associated protein of 267 kDa
  • ARA267STO
  • DKFZp666C163
  • EC 2.1.1.43
  • FLJ10684
  • FLJ22263
  • FLJ44628
  • H3 lysine-36 and H4 lysine-20 specific
  • KMT3BSotos syndrome
  • Lysine N-methyltransferase 3B
  • NR-binding SET domain-containing protein
  • nuclear receptor binding SET domain protein 1

Background

KMT3B/NSD1 is a histone methyltransferase that preferentially methylates Lys-36 of histone H3 and Lys-20 of histone H4. KMT3B/NSD1 can function as an androgen receptor coactivator and is capable of both negatively and positively influencing transcription. Mutations in KMT3B/NSD1 are responsible for Sotos syndrome, Weaver syndrome, Beckwith-Wiedemann syndrome, and a form of childhood leukemia. Alternate names for KMT3B/NSD1 include nuclear receptor binding SET domain protein 1, ARA267, ARA-267 androgen receptor-associated coregulator 267, STO, SOTOS, Sotos syndrome, and FLJ22263.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for KMT3B/NSD1 Antibody (NB100-1744)(1)

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Secondary Antibodies

 

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Bioinformatics

Gene Symbol NSD1
Entrez
Uniprot