KMT3B/NSD1 Products

Antibodies
KMT3B/NSD1 Antibody
KMT3B/NSD1 Antibody
NB100-1744
Species: Hu
Applications: IHC, IHC-P
Host: Rabbit Polyclonal
KMT3B/NSD1 Antibody (4F1)
KMT3B/NSD1 Antibody (4F1)
H00064324-M08
Species: Hu
Applications: WB, ELISA
Host: Mouse Monoclonal
KMT3B/NSD1 Antibody (3E6)
KMT3B/NSD1 Antibody (3E6)
H00064324-M06
Species: Hu
Applications: WB, ELISA
Host: Mouse Monoclonal
Proteins
Recombinant Human KMT3B/NSD1 ...
Recombinant Human KMT3B/NSD1 Protein
H00064324-Q01
Species: Hu
Applications: WB, ELISA, PA
RNAi
KMT3B/NSD1 RNAi
KMT3B/NSD1 RNAi
H00064324-R02
Species: Hu
Applications: RNAi, RNAi SP
KMT3B/NSD1 RNAi
KMT3B/NSD1 RNAi
H00064324-R01
Species: Hu
Applications: RNAi, RNAi SP

Description

KMT3B / NSD1 encodes a protein containing a SET domain, 2 LXXLL motifs, 3 nuclear translocation signals (NLSs), 4 plant homeodomain (PHD) finger regions, and a proline-rich region. The encoded protein enhances androgen receptor (AR) transactivation, and this enhancement can be increased further in the presence of other androgen receptor associated coregulators. This protein may act as a nucleus-localized, basic transcriptional factor and also as a bifunctional transcriptional regulator. Mutations of this gene have been associated with Sotos syndrome and Weaver syndrome. One version of childhood acute myeloid leukemia is the result of a cryptic translocation with the breakpoints occurring within nuclear receptor-binding Su-var, enhancer of zeste, and trithorac domain protein 1 on chromosome 5 and nucleoporin, 98-kd on chromosome 11. Two transcript variants encoding distinct isoforms have been identified for this gene.

Bioinformatics

Entrez Human
Uniprot Human
Human
Product By Gene ID 64324
Alternate Names
  • NR-binding SET domain-containing protein
  • H3 lysine-36 and H4 lysine-20 specific
  • Lysine N-methyltransferase 3B
  • FLJ44628
  • Androgen receptor-associated protein of 267 kDa
  • FLJ10684
  • Androgen receptor coactivator 267 kDa protein
  • DKFZp666C163
  • FLJ22263
  • KMT3BSotos syndrome
  • ARA267STO
  • EC 2.1.1.43
  • nuclear receptor binding SET domain protein 1

Research Areas for KMT3B/NSD1

Find related products by research area and learn more about each of the different research areas below.

Apoptosis
Breast Cancer
Cancer
Cellular Markers
Tumor Suppressors

PTMs for KMT3B/NSD1

Learn more about PTMs related to KMT3B/NSD1.

Methylation
Phosphorylation
Acetylation
Demethylation

Bioinformatics Tool for KMT3B/NSD1

Discover related pathways, diseases and genes to KMT3B/NSD1. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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