Kir6.2 Antibody

Images

 
Western Blot: Kir6.2 Antibody [NBP1-00206] - (0.1ug/ml) staining of Human Muscle lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
Immunohistochemistry-Paraffin: Kir6.2 Antibody [NBP1-00206] - (3.8ug/ml) staining of paraffin embedded Human Pancreas. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.

Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB, IHC, IHC-P, PEP-ELISA
Clonality
Polyclonal
Host
Goat
Conjugate
Unconjugated
Concentration
0.5 mg/ml

Order Details

Kir6.2 Antibody Summary

Immunogen
Peptide with sequence C-AEDPAKPRYRARQ corresponding to internal region (near N-Terminus) according to NP_000516.3.
Specificity
This antibody is expected to recognise isoform 1 (NP_000516.3) only.
Isotype
IgG
Clonality
Polyclonal
Host
Goat
Gene
KCNJ11
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 0.1 - 0.3 ug/ml
  • Immunohistochemistry 3 - 5 ug/ml
  • Immunohistochemistry-Paraffin 3 - 5 ug/ml
  • Peptide ELISA Detection limit 1:32000
Application Notes
WB: Approx. 45-48 kDa band observed in human skeletal muscle lysates (calculated MW of 43.5 kDa band according to NP_000516.3). IHC-P: Human pancreas shows variable staining across the islet of langerhans.
Publications
Read Publication using NBP1-00206.

Packaging, Storage & Formulations

Storage
Store at -20C. Avoid freeze-thaw cycles.
Buffer
0.5 mg/ml Tris (pH 7.3) and 0.5% BSA
Preservative
0.02% Sodium Azide
Concentration
0.5 mg/ml
Purity
Immunogen affinity purified

Alternate Names for Kir6.2 Antibody

  • ATP-sensitive inward rectifier potassium channel 11
  • beta-cell inward rectifier subunit
  • BIRKIR6.2
  • HHF2
  • IKATP
  • Inward rectifier K(+) channel Kir6.2
  • inwardly rectifying potassium channel KIR6.2
  • Kir6.2
  • MGC133230
  • PHHI
  • potassium channel inwardly rectifing subfamily J member 11
  • Potassium channel, inwardly rectifying subfamily J member 11
  • potassium inwardly-rectifying channel, subfamily J, member 11
  • TNDM3

Background

Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins and is found associated with the sulfonylurea receptor SUR. Mutations in this gene are a cause of familial persistent hyperinsulinemic hypoglycemia of infancy (PHHI), an autosomal recessive disorder characterized by unregulated insulin secretion. Defects in this gene may also contribute to autosomal dominant non-insulin-dependent diabetes mellitus type II (NIDDM), transient neonatal diabetes mellitus type 3 (TNDM3), and permanent neonatal diabetes mellitus (PNDM). [provided by RefSeq]

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for Kir6.2 Antibody (NBP1-00206)(1)

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Secondary Antibodies

 

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Bioinformatics

Gene Symbol KCNJ11
Entrez
Uniprot