Kir6.2 Products

Description

Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins and is found associated with the sulfonylurea receptor SUR. Mutations in this gene are a cause of familial persistent hyperinsulinemic hypoglycemia of infancy (PHHI), an autosomal recessive disorder characterized by unregulated insulin secretion. Defects in this gene may also contribute to autosomal dominant non-insulin-dependent diabetes mellitus type II (NIDDM), transient neonatal diabetes mellitus type 3 (TNDM3), and permanent neonatal diabetes mellitus (PNDM). [provided by RefSeq]

Bioinformatics

Entrez	16514 Mouse 3767 Human 83535 Rat
Uniprot	NP_000516 Human NP_000516.3 Human NP_034732.1 Mouse Q14654 Human
Product By Gene ID	3767
Alternate Names	ATP-sensitive inward rectifier potassium channel 11 beta-cell inward rectifier subunit BIRKIR6.2 HHF2 IKATP Inward rectifier K(+) channel Kir6.2 inwardly rectifying potassium channel KIR6.2 Kir6.2 MGC133230 PHHI potassium channel inwardly rectifing subfamily J member 11 Potassium channel, inwardly rectifying subfamily J member 11 potassium inwardly-rectifying channel, subfamily J, member 11 TNDM3