Kir2.1 Antibody (2153C) [Alexa Fluor® 350]

• Reactivity: Hu, Mu
• Applications: WB, IHC, ICC/IF
• Clone: 2153C
• Clonality: Monoclonal
• Host: Rabbit
• Conjugate: Alexa Fluor 350

Kir2.1 Antibody (2153C) [Alexa Fluor® 350] Summary

• Additional Information: Recombinant Monoclonal Antibody.
• Immunogen: E. coli-derived recombinant human Kir2.1
  Asn352-Ile427
  Accession # P63252
• Specificity: Detects human Kir2.1 in direct ELISAs. Detects human and mouse Kir2.1 in Immunohistochemistry.
• Isotype: IgG
• Clonality: Monoclonal
• Host: Rabbit
• Purity Statement: Protein A or G purified

Applications/Dilutions

• Dilutions:
  • Immunocytochemistry
  • Immunohistochemistry
  • Western Blot

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Kir2.1 Antibody (2153C) [Alexa Fluor® 350]

• ATFB9
• Cardiac inward rectifier potassium channel
• HHBIRK1
• HHIRK1
• HIRK1
• Inward rectifier K(+) channel Kir2.1
• inward rectifier K+ channel KIR2.1
• inward rectifier potassium channel 2
• IRK1
• IRK-1
• IRK1LQT7
• KCNJ2
• Kir2.1
• LQT7
• Potassium channel, inwardly rectifying subfamily J member 2
• potassium inwardly-rectifying channel, subfamily J, member 2
• SQT3

Background

Human Inward Rectifier Potassium Channel 2 (KIR2.1), also known as KCNJ2, is a 427 amino acid (aa) integral membrane protein with 98% homology with mouse and rat KIR2.1.   This potassium channel preferentially allows potassium to flow into the cell, which is thought to generate action potential waveform and excitability in neuronal and muscle tissues. Mutations in the KIR2.1 gene are associated with Andersen syndrome, with associated paralysis, cardiac arrhythmias and dysmorphic features. KIR2.1 is widely expressed, notably in heart, placenta, lung, skeletal muscle, kidney and spleen. Expression of KIR2.1 is necessary for development of mature cardiomyocytes from mouse embryonic stem cells.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.