Kir2.1 Products

Kir2.1 Antibody
Kir2.1 Antibody
Species: Hu, Mu, Rt
Applications: IHC, IHC-P
Host: Rabbit Polyclonal
Kir2.1 Antibody
Kir2.1 Antibody
Species: Hu
Applications: WB
Host: Rabbit Polyclonal
Kir2.1 Antibody
Kir2.1 Antibody
Species: Hu, Mu
Applications: WB
Host: Rabbit Polyclonal
Recombinant Human Kir2.1 GST ...
Recombinant Human Kir2.1 GST (N-Te...
Species: Hu
Applications: WB, ELISA, PA, AP


FUNCTION: Probably participates in establishing action potential waveform and excitability of neuronal and muscle tissues. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium or cesium.; Tissue specificity: Heart, brain, placenta, lung, skeletal muscle, and kidney. Diffusely distributed throughout the brain.; Subcellular location: Membrane, Multi-pass membrane protein.; Involvement in disease: Defects in KCNJ2 are the cause of long QT syndrome type 7 (LQT7); also called Andersen syndrome or Andersen cardiodysrhythmic periodic paralysis. Long QT syndromes are heart disorders characterized by a prolonged QT interval on the ECG and polymorphic ventricular arrhythmias. They cause syncope and sudden death in response to excercise or emotional stress. LQT7 manifests itself as a clinical triad consisting of potassium-sensitive periodic paralysis, ventricular ectopy and dysmorphic features.; Defects in KCNJ2 are the cause of short QT syndrome type 3 (SQT3). Short QT syndromes are heart disorders characterized by idiopathic persistently and uniformly short QT interval on ECG in the absence of structural heart disease in affected individuals. They cause syncope and sudden death. SQT3 has a unique ECG phenotype characterized by asymmetrical T waves.


Entrez Human
Uniprot Human
Product By Gene ID 3759
Alternate Names
  • HHIRK1
  • inward rectifier potassium channel 2
  • hIRK1
  • inward rectifier K+ channel KIR2.1
  • IRK-1
  • Potassium channel, inwardly rectifying subfamily J member 2
  • Kir2.1
  • Inward rectifier K(+) channel Kir2.1
  • SQT3
  • Cardiac inward rectifier potassium channel
  • IRK1LQT7
  • KIR2.1
  • potassium inwardly-rectifying channel, subfamily J, member 2

PTMs for Kir2.1

Learn more about PTMs related to Kir2.1.


Bioinformatics Tool for Kir2.1

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