Kir2.1 Products

Antibodies
Kir2.1 Antibody (S112B-14)
Kir2.1 Antibody (S112B-14)
NBP2-12900
Species: Mu
Applications: WB, ICC/IF, IHC, IHC-P
Host: Mouse Monoclonal
Kir2.1 Antibody
Kir2.1 Antibody
NBP1-87709
Species: Hu, Mouse, Rat
Applications: IHC, IHC-P
Host: Rabbit Polyclonal
Proteins
Kir2.1 Partial Recombinant Pr ...
Kir2.1 Partial Recombinant Protein
H00003759-Q01
Species: Hu
Applications: WB, ELISA, PA
Kir2.1 Recombinant Protein An ...
Kir2.1 Recombinant Protein Antigen
NBP1-87709PEP
Species: Hu
Applications: AC
RNAi
Kir2.1 RNAi
Kir2.1 RNAi
H00003759-R01
Species: Hu

Description

FUNCTION: Probably participates in establishing action potential waveform and excitability of neuronal and muscle tissues. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium or cesium.; Tissue specificity: Heart, brain, placenta, lung, skeletal muscle, and kidney. Diffusely distributed throughout the brain.; Subcellular location: Membrane, Multi-pass membrane protein.; Involvement in disease: Defects in KCNJ2 are the cause of long QT syndrome type 7 (LQT7); also called Andersen syndrome or Andersen cardiodysrhythmic periodic paralysis. Long QT syndromes are heart disorders characterized by a prolonged QT interval on the ECG and polymorphic ventricular arrhythmias. They cause syncope and sudden death in response to excercise or emotional stress. LQT7 manifests itself as a clinical triad consisting of potassium-sensitive periodic paralysis, ventricular ectopy and dysmorphic features.; Defects in KCNJ2 are the cause of short QT syndrome type 3 (SQT3). Short QT syndromes are heart disorders characterized by idiopathic persistently and uniformly short QT interval on ECG in the absence of structural heart disease in affected individuals. They cause syncope and sudden death. SQT3 has a unique ECG phenotype characterized by asymmetrical T waves.

Bioinformatics

Entrez Human
Uniprot Human
Human
Product By Gene ID 3759
Alternate Names
  • HHIRK1
  • inward rectifier potassium channel 2
  • hIRK1
  • inward rectifier K+ channel KIR2.1
  • IRK-1
  • HHBIRK1
  • Potassium channel, inwardly rectifying subfamily J member 2
  • Kir2.1
  • Inward rectifier K(+) channel Kir2.1
  • SQT3
  • Cardiac inward rectifier potassium channel
  • IRK1LQT7
  • KIR2.1
  • potassium inwardly-rectifying channel, subfamily J, member 2

PTMs for Kir2.1

Learn more about PTMs related to Kir2.1.

Phosphorylation
Nitrosylation
Dephosphorylation

Bioinformatics Tool for Kir2.1

Discover related pathways, diseases and genes to Kir2.1. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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