JMJD2D Antibody

Product Discontinued

JMJD2D Antibody Summary

• Immunogen: JMJD2D (NP_060509.2, 1 a.a. ~ 523 a.a) full-length human protein.METMKSKANCAQNPNCNIMIFHPTKEEFNDFDKYIAYMESQGAHRAGLAKIIPPKEWKARETYDNISEILIATPLQQVASGRAGVFTQYHKKKKAMTVGEYRHLANSKKYQTPPHQNFEDLERKYWKNRIYNSPIYGADISGSLFDENTKQWNLGHLGTIQDLLEKECGVVIEGVNTPYLYFGMWKTTFAWHTEDMDLYSINYLHLGEPKTWYVVPPEHGQRLERLARELFPGSSRGCGAFLRHKVALISPTVLK
• Specificity: Reacts with jumonji domain containing 2D.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: KDM4D
• Purity: Protein A purified

Applications/Dilutions

• Dilutions:
  • ELISA
  • Immunocytochemistry/ Immunofluorescence
  • Western Blot
• Application Notes: This antibody is reactive against transfected lysate in western blot, and as a detection antibody in ELISA.

Reactivity Notes

Human

Packaging, Storage & Formulations

• Storage: Store at -20C. Avoid freeze-thaw cycles.
• Buffer: PBS (pH 7.4)
• Preservative: No Preservative
• Purity: Protein A purified

Notes

This product is produced by and distributed for Abnova, a company based in Taiwan.

Alternate Names for JMJD2D Antibody

• EC 1.14.11
• EC 1.14.11.-
• FLJ10251
• JHDM3D
• JmjC domain-containing histone demethylation protein 3D
• JMJD2D
• JMJD2Dlysine-specific demethylase 4D
• jumonji domain containing 2D
• Jumonji domain-containing protein 2D
• KDM4D
• lysine (K)-specific demethylase 4D
• MGC141909

Background

JMJD2 is a member of the family of novel JmjC domain-containing histone demethylation (JHDM) enzymes, which has been shown to perform the enzymatic removal of methyl groups from histones. Histone demethylation by JHDM proteins requires cofactors Fe(II) and alpha-ketoglutarate. Family members include JHDM1 (demethylating histone 3 at lysine 36), and JHDM2A as well as JMJD2CH3K9 (both of which demethylate histone 3 at lysine 9). Histone demethylase activity has been linked to tumor development, decreases in cell proliferation, and hormone-dependent transcriptional activation.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: KDM4D
• Entrez:
  • 55693(Human)
• Uniprot:
  • NP_060509.2(Human)