JMJD2D Products

Description

JMJD2 is a member of the family of novel JmjC domain-containing histone demethylation (JHDM) enzymes, which has been shown to perform the enzymatic removal of methyl groups from histones. Histone demethylation by JHDM proteins requires cofactors Fe(II) and alpha-ketoglutarate. Family members include JHDM1 (demethylating histone 3 at lysine 36), and JHDM2A as well as JMJD2CH3K9 (both of which demethylate histone 3 at lysine 9). Histone demethylase activity has been linked to tumor development, decreases in cell proliferation, and hormone-dependent transcriptional activation.

Bioinformatics

Entrez	55693 Human
Uniprot	NM_018039 Human NP_060509 Human NP_060509.2 Human Q6B0I6 Human
Product By Gene ID	55693
Alternate Names	EC 1.14.11 EC 1.14.11.- FLJ10251 JHDM3D JmjC domain-containing histone demethylation protein 3D JMJD2Dlysine-specific demethylase 4D jumonji domain containing 2D Jumonji domain-containing protein 2D lysine (K)-specific demethylase 4D MGC141909

Research Areas for JMJD2D

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Transcription Factors and Regulators