Isocitrate Dehydrogenase 2/IDH2 Antibody (1069032) [Alexa Fluor® 532]

• Reactivity: Hu
• Applications: IHC, Flow, ICC/IF
• Clone: 1069032
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor 532

Isocitrate Dehydrogenase 2/IDH2 Antibody (1069032) [Alexa Fluor® 532] Summary

• Immunogen: E. coli-derived recombinant human IDH-2
  Thr376-Gln452
  Accession # P48735
• Specificity: Detects human IDH-2 in direct ELISA.
• Isotype: IgG2b
• Clonality: Monoclonal
• Host: Mouse
• Purity Statement: Protein A or G purified

Applications/Dilutions

• Dilutions:
  • Immunocytochemistry
  • Immunohistochemistry
  • Intracellular Staining by Flow Cytometry

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Isocitrate Dehydrogenase 2/IDH2 Antibody (1069032) [Alexa Fluor® 532]

• D2HGA2
• ICD-M
• IDH2
• IDHM
• IDPM
• Isocitrate Dehydrogenase 2

Background

Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. Each NADP(+)-dependent isozyme is a homodimer. The protein encoded by this gene is the NADP(+)-dependent isocitrate dehydrogenase found in the mitochondria. It plays a role in intermediary metabolism and energy production. This protein may tightly associate or interact with the pyruvate dehydrogenase complex.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.