Integrin beta 8 Antibody (416922) [Allophycocyanin]

WM-115 human melanoma cell line was stained with Mouse Anti-Human Integrin beta 8 APC-conjugated Monoclonal Antibody (Catalog # FAB4775A, filled histogram) or isotype control antibody (Catalog # IC0041A, open histogram). View our protocol for Staining Membrane-associated Proteins.

• Reactivity: Hu
• Applications: Flow
• Clone: 416922
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Allophycocyanin

Integrin beta 8 Antibody (416922) [Allophycocyanin] Summary

• Immunogen: Mouse myeloma cell line NS0-derived recombinant human Integrin beta 8
  Glu43-Arg684 (predicted)
  Accession # P26012
• Specificity: Detects human Integrin beta 8 in direct ELISAs. In direct ELISAs, no cross-reactivity with recombinant human Integrins beta 1, beta 2, beta 3, beta 4, beta 5, beta 6 beta 7, or recombinant mouse Integrin beta 8 is observed.
• Source: N/A
• Isotype: IgG2b
• Clonality: Monoclonal
• Host: Mouse
• Gene: ITGB8
• Purity Statement: Protein A or G purified from hybridoma culture supernatant

Applications/Dilutions

• Dilutions:
  • Flow Cytometry 10 uL/10^6 cells

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze.
  • 12 months from date of receipt, 2 to 8 °C as supplied.
• Buffer: Supplied in a saline solution containing BSA and Sodium Azide.
• Preservative: Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Integrin beta 8 Antibody (416922) [Allophycocyanin]

• Integrin beta 8
• integrin beta-8
• integrin, beta 8
• ITGB8

Background

Integrin beta 8 (Integrin beta 8) is a 90 kDa type I transmembrane glycoprotein of the Integrin family of adhesion molecules. It associates with Integrin alpha V to form a receptor for vitronectin, fibrin, and the latency associated peptide (LAP). Binding to LAP promotes the proteolytic release of active TGF-beta from LAP. Integrin alpha V beta 8 is required for vascular morphogenesis in the embryonic brain and yolk sac. Within the extracellular domain, human Integrin  beta 8 shares 87% aa sequence identity with mouse and rat Integrin  beta 8.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for Integrin beta 8 Antibody (FAB4775A)(1)

Publication using FAB4775A

• Stefano Tomassi, Vincenzo Maria D’Amore, Francesco Saverio Di Leva, Andrea Vannini, Giacomo Quilici, Michael Weinmüller et al. Halting the Spread of Herpes Simplex Virus-1: The Discovery of an Effective Dual alpha v beta 6/ alpha v beta 8 Integrin Ligand Journal of Medicinal Chemistry 2021-05-27 [PMID: 33961417]

Bioinformatics

• Gene Symbol: ITGB8
• Uniprot:
  • P26012()