Integrin beta 7 Antibody (332418)

• Reactivity: Mu
• Applications: Flow, CyTOF-ready
• Clone: 332418
• Clonality: Monoclonal
• Host: Rat
• Conjugate: Unconjugated
• Concentration: LYOPH

Integrin beta 7 Antibody (332418) Summary

• Immunogen: Chinese hamster ovary cell line CHO-derived recombinant mouse Integrin beta 7
  Glu20-His722
  Accession # P26011
• Specificity: Detects mouse Integrin beta 7 extracellular domain in direct ELISAs.
• Source: N/A
• Isotype: IgG2a
• Clonality: Monoclonal
• Host: Rat
• Gene: ITGB7
• Purity Statement: Protein A or G purified from hybridoma culture supernatant

Applications/Dilutions

• Dilutions:
  • CyTOF-ready
  • Flow Cytometry 2.5 ug/10^6 cells

Packaging, Storage & Formulations

• Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  12 months from date of receipt, -20 to -70 degreesC as supplied. 1 month, 2 to 8 degreesC under sterile conditions after reconstitution. 6 months, -20 to -70 degreesC under sterile conditions after reconstitution.
• Buffer: Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
• Preservative: No Preservative
• Concentration: LYOPH
• Reconstitution Instructions: Reconstitute at 0.5 mg/mL in sterile PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Integrin beta 7 Antibody (332418)

• Gut homing receptor beta subunit
• integrin beta 7 subunit
• Integrin beta 7
• integrin beta-7
• integrin, beta 7
• ITGB7

Background

Integrin beta 7 associates with the integrin alpha 4 or alpha E subunits to form heterodimers to interact with fibronectin, VCAM, MAdCAM or E-Cadherin. It is highly expressed in leukocytes and is involved in localization of leukocytes at mucosal sites.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for Integrin beta 7 Antibody (MAB3060)(1)

Publication using MAB3060

• Richard JF, Roy M, Audoy-Remus J, Tremblay P, Vallieres L Crawling Phagocytes Recruited in the Brain Vasculature after Pertussis Toxin Exposure through IL6, ICAM1 and ITGalphaM. Brain Pathol., 2011-05-23;21(0):661. 2011-05-23 [PMID: 21418369] (Neutralization, Mouse)

Bioinformatics

• Gene Symbol: ITGB7
• Uniprot:
  • P26011()