Integrin alpha 9 Antibody [Unconjugated]

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Product Details

Summary
Reactivity MuSpecies Glossary
Applications WB, Flow, CyTOF-ready
Clonality
Polyclonal
Host
Goat
Conjugate
Unconjugated
Concentration
LYOPH

Order Details

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Catalog# & Conjugate Size Price

Integrin alpha 9 Antibody [Unconjugated] Summary

Immunogen
Mouse myeloma cell line NS0-derived recombinant mouse Integin alpha 9
Try31-Val979
Accession # NP_598482
Specificity
Detects mouse Integrin alpha 9 in direct ELISAs and Western blots. In direct ELISAs and Western blots, less than 5% cross-reactivity with recombinant human Integrin alpha 1, alpha 8, alpha 9, alpha L, recombinant mouse Integrin 3, 4, 5, E, and M is observed.
Source
N/A
Isotype
IgG
Clonality
Polyclonal
Host
Goat
Gene
ITGA9
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 0.1 ug/mL
  • Flow Cytometry 2.5 ug/10^6 cells
  • CyTOF-ready
Publications
Read Publications using
AF3827 in the following applications:

Packaging, Storage & Formulations

Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied as a 0.2 µm filtered solution in PBS.
Preservative
No Preservative
Concentration
LYOPH
Reconstitution Instructions
Reconstitute at 0.2 mg/mL in sterile PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Integrin alpha 9 Antibody [Unconjugated]

  • ALPHA-RLC
  • Integrin alpha 9
  • integrin alpha-9
  • Integrin alpha-RLC
  • integrin, alpha 9
  • ITGA4L
  • ITGA9
  • RLC
  • RLC-alpha

Background

Integrin alpha 9 is a 150 kDa type I transmembrane glycoprotein that is widely expressed and is found on smooth muscle, keratinocytes, skeletal muscle and hepatocytes. It principally associates with the beta 1 integrin. alpha 9 beta 1 binds to VEGF-C, VEGF-D, and osteopontin. The 951 amino acid (aa) extracellular domain of mouse integrin alpha 9 contains three beta -propellor repeats and multiple PheGly-GlyAlaPro repeats. A potential proteolytic cleavage site in human alpha 9 ECD is absolutely conserved in mouse alpha 9 ECD (Arg566-Val567). The ECD of mouse integrin alpha 9 shares 95% and 89% aa sequence identity to rat and human integrin alpha 9, respectively.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for Integrin alpha 9 Antibody (AF3827)(15)

We have publications tested in 2 confirmed species: Human, Mouse.

We have publications tested in 7 applications: Flow, IHC, IHC Fresh, IHC Frozen, IHC Not Specified, IHC-Fluorescent, IHC-OCT embedded.


Filter By Application
Flow
(4)
IHC
(3)
IHC Fresh
(1)
IHC Frozen
(3)
IHC Not Specified
(1)
IHC-Fluorescent
(1)
IHC-OCT embedded
(1)
All Applications
Filter By Species
Human
(2)
Mouse
(12)
All Species
Showing Publications 1 - 10 of 15. Show All 15 Publications.
Publications using AF3827 Applications Species
Integrin Alpha 9 Blockade Suppresses Lymphatic Valve Formation and Promotes Transplant Survival Invest. Ophthalmol. Vis. Sci., 2016;57(14):5935-5939. 2016 [PMID: 27806381] (IHC-Fluorescent,, Mouse) IHC-Fluorescent Mouse
Geng X, Cha B, Mahamud M, Lim K, Silasi-Mansat R, Uddin M, Miura N, Xia L, Simon A, Engel J, Chen H, Lupu F, Srinivasan R Multiple mouse models of primary lymphedema exhibit distinct defects in lymphovenous valve development. Dev Biol, 2016;409(1):218-33. 2016 [PMID: 26542011] (IHC-OCT embedded,, Mouse) IHC-OCT embedded Mouse
Ruppert R, Moser M, Sperandio M, Rognoni E, Orban M, Liu W, Schulz A, Oostendorp R, Massberg S, Fassler R Kindlin-3-mediated integrin adhesion is dispensable for quiescent but essential for activated hematopoietic stem cells. J Exp Med, 2015;212(9):1415-32. 2015 [PMID: 26282877] (Flow,, Mouse) Flow Mouse
Louveau A, Smirnov I, Keyes T, Eccles J, Rouhani S, Peske J, Derecki N, Castle D, Mandell J, Lee K, Harris T, Kipnis J Structural and functional features of central nervous system lymphatic vessels. Nature, 2015;523(7560):337-41. 2015 [PMID: 26030524] (IHC Not Specified,, Mouse) IHC Not Specified Mouse
Aspelund A, Tammela T, Antila S, Nurmi H, Leppanen V, Zarkada G, Stanczuk L, Francois M, Makinen T, Saharinen P, Immonen I, Alitalo K The Schlemm's canal is a VEGF-C/VEGFR-3-responsive lymphatic-like vessel. J Clin Invest, 2014;124(9):3975-86. 2014 [PMID: 25061878] (IHC Fresh,, Mouse) IHC Fresh Mouse
Park D, Lee J, Park I, Choi D, Lee S, Song S, Hwang Y, Hong K, Nakaoka Y, Makinen T, Kim P, Alitalo K, Hong Y, Koh G Lymphatic regulator PROX1 determines Schlemm's canal integrity and identity. J Clin Invest, 2014;124(9):3960-74. 2014 [PMID: 25061877]
Zheng W, Nurmi H, Appak S, Sabine A, Bovay E, Korhonen E, Orsenigo F, Lohela M, D'Amico G, Holopainen T, Leow C, Dejana E, Petrova T, Augustin H, Alitalo K Angiopoietin 2 regulates the transformation and integrity of lymphatic endothelial cell junctions. Genes Dev, 2014;28(14):1592-603. 2014 [PMID: 25030698] (IHC Frozen,, Mouse) IHC Frozen Mouse
Truong, Tan, Huang, Eric, Yuen, Don, Chen, Lu Corneal lymphatic valve formation in relation to lymphangiogenesis. Invest Ophthalmol Vis Sci, 2014;55(3):1876-83. 2014 [PMID: 24595382] (IHC,, Mouse) IHC Mouse
Smooth muscle-endothelial cell communication activates Reelin signaling and regulates lymphatic vessel formation. J. Cell Biol., 2012;197(6):837-49. 2012 [PMID: 22665518] (IHC,, Mouse) IHC Mouse
Sato-Nishiuchi R, Nakano I, Ozawa A, Sato Y, Takeichi M, Kiyozumi D, Yamazaki K, Yasunaga T, Futaki S, Sekiguchi K Polydom/SVEP1 Is a Ligand for Integrin alpha9beta1. J. Biol. Chem., 2012;287(30):25615-30. 2012 [PMID: 22654117] (IHC Frozen,, Mouse) IHC Frozen Mouse
Show All 15 Publications.

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Bioinformatics

Gene Symbol ITGA9
Entrez
Uniprot