Integrin beta 7 Products

Description

Integrin beta7 is a 130 kD glycoprotein, also known as integin betap. It is a member of the Ig superfamily. In association with integrin alpha4 or alphaE chain, beta7 forms alpha4/ beta7 or alphaE/ beta7 heterodimer. alpha4/ beta7 (CD49d/ beta7, LPAM-1) is expressed on majority of peripheral lymphocytes, small subsets of thymocytes and bone marrow progenitors. LPAM-1 binds to several ligands, VCAM-1, MAdCAM-1 and fibronectin, and is involved in lymphocyte adhesion, some hematopoietic progenitor cells migration. alphaE/ beta7 (CD103/ beta7, alphaIEL/ beta7) is expressed on intestinal intraepithelial lymphocytes (IEL), dendritic epidermal T cells, T regulatory cells, a subset of CD8+ T cells in lymph nodes and lamina propria. CD103/ beta7 complex is thought to play a role in lymphocyte retention via interaction with its lignd E-Cadherin. The Fib504 antibody has been reported to react with mouse and human beta7 integrin and to block beta7 integrin-mediated cell adhesion in in vitro and in vivo studies.

Bioinformatics

Entrez	16401 Mouse 16421 Mouse 3695 Human
Uniprot	NM_000889 Human NP_000880 Human NP_000880.1 Human P26010 Human P26011 Mouse
Product By Gene ID	3695
Alternate Names	Gut homing receptor beta subunit integrin beta 7 subunit integrin beta-7 integrin, beta 7

Research Areas for Integrin beta 7

Find related products by research area and learn more about each of the different research areas below.

Signal Transduction