Integrin alpha 6/CD49f Antibody (MP4F10) - BSA Free

Product Discontinued

Integrin alpha 6/CD49f Antibody (MP4F10) - BSA Free Summary

• Immunogen: SW1222 human colorectal cell line.
• Localization: Cell Membrane
• Clonality: Monoclonal
• Host: Mouse
• Gene: ITGA6
• Purity: Protein A purified

Applications/Dilutions

• Dilutions:
  • CyTOF-ready
  • Flow Cytometry 1:10 - 1:1000
  • Immunocytochemistry/ Immunofluorescence
  • Immunohistochemistry 1:10 - 1:500
  • Immunoprecipitation 1:10 - 1:500
  • Western Blot
• Application Notes: This antibody is Cytof ready. Use in Immunocytochemistry/immunofluorescence reported in scientific literature (PMID: 30042176).

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: PBS
• Preservative: 0.02% Sodium Azide
• Concentration: 1 mg/ml
• Purity: Protein A purified

Alternate Names for Integrin alpha 6/CD49f Antibody (MP4F10) - BSA Free

• CD49 antigen-like family member F
• CD49f antigen
• CD49f
• DKFZp686J01244
• FLJ18737
• Integrin alpha 6
• integrin alpha-6
• integrin alpha6B
• integrin, alpha 6
• ITGA6
• ITGA6B
• Platelet gpl
• VLA-6

Background

Integrins are important extracellular matrix (ECM) receptor proteins located on cell surfaces. They are hetrodimers composed of an alpha and a beta transmembrane glycoprotein subunit. Around twenty two different integrins (different alpha/ beta subunit combinations) are found in nature. Integrins are generally present in high concentrations at the cell surface, but, unlike most other cell surface receptors, they bind ligands with very low affinity. Due to their weak individual binding, integrins need to cluster and bind in groups in order to effectively bind the ECM. Integrins bind many different ligands including laminin. Each integrin is made up of a large N terminal extracellular domain that binds the ECM ligand and a small C terminal cytoplasmic domain that mediates interaction with the actin cytoskeleton and signaling function. Integrin alpha 6 complexes are receptors for laminins, which are components of basement membranes. Integrin alpha 6 complexes may play an important role in embryogenesis.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for Integrin alpha 6/CD49f Antibody (NB100-2676)(1)

Publication using NB100-2676

• Eke I, Makinde AY, Aryankalayil MJ et al. Long-Term Tumor Adaptation after Radiotherapy: Therapeutic Implications for Targeting Integrins in Prostate Cancer Mol. Cancer Res. 2018-07-24 [PMID: 30042176] (ICC/IF)

Bioinformatics

• Gene Symbol: ITGA6
• Entrez:
  • 3655(Human)