Activin A Antibody

Product Discontinued

Activin A Antibody Summary

• Immunogen: INHBA fusion protein ag1001
• Specificity: Inhibin Beta-1
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: INHBA
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Block/Neutralize
  • ELISA 1:1000-1:100000
  • Immunocytochemistry/ Immunofluorescence 1:25
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Paraffin 1:50-1:100
  • Western Blot 1:100-1:000
• Application Notes: Tested in Human, Mouse, and Rat. Other species are not tested.Blocking/Neutralizing was reported in scientific literature. Please decide the specificity by homology.
• Theoretical MW: 47 kDa.
  Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Packaging, Storage & Formulations

• Storage: Store at -20C. Avoid freeze-thaw cycles.
• Buffer: PBS (pH 7.3) and 50% Gycerol
• Preservative: 0.1% Sodium Azide
• Concentration: 0.1 mg/ml
• Purity: Immunogen affinity purified

Alternate Names for Activin A Antibody

• Activin A
• activin AB alpha polypeptide
• Activin beta-A chain
• erythroid differentiation factor
• Erythroid differentiation protein
• follicle-stimulating hormone-releasing protein
• FSH-releasing protein
• inhibin beta A chain
• inhibin beta A subunit
• Inhibin, beta-1

Background

The inhibin beta A subunit joins the alpha subunit to form a pituitary FSH secretion inhibitor. Inhibin has been shown to regulate gonadal stromal cell proliferation negatively and to have tumor-suppressor activity. In addition, serum levels of inhibin have been shown to reflect the size of granulosa-cell tumors and can therefore be used as a marker for primary as well as recurrent disease. Because expression in gonadal and various extragonadal tissues may vary severalfold in a tissue-specific fashion, it is proposed that inhibin may be both a growth/differentiation factor and a hormone. Furthermore, the beta A subunit forms a homodimer, activin A, and also joins with a beta B subunit to form a heterodimer, activin AB, both of which stimulate FSH secretion. Finally, it has been shown that the beta A subunit mRNA is identical to the erythroid differentiation factor subunit mRNA and that only one gene for this mRNA exists in the human genome.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for Activin A Antibody (NB110-61019)(5)

Publications using NB110-61019

• Sallustio F, Curci C, Aloisi A et al. Inhibin-A and Decorin Secreted by Human Adult Renal Stem/Progenitor Cells Through the TLR2 Engagement Induce Renal Tubular Cell Regeneration Sci Rep 2017 Aug 15 [PMID: 28811645] (IHC-P, Human)
• Sallustio F, Curci C, Aloisi A et al. Inhibin-A and Decorin Secreted by Human Adult Renal Stem/Progenitor Cells Through the TLR2 Engagement Induce Renal Tubular Cell Regeneration Sci Rep 2017 Aug 15 [PMID: 28811645] (B/N, Human)
• Gasi Tandefelt D, Boormans JL, van der Korput HA et al. A 36-gene Signature Predicts Clinical Progression in a Subgroup of ERG-positive Prostate Cancers. Eur Urol 2013-03-07 [PMID: 23490727] (WB, Human)
• Sallustio F, Costantino V, Cox SN et al. Human renal stem/progenitor cells repair tubular epithelial cell injury through TLR2-driven inhibin-A and microvesicle-shuttled decorin. Kidney Int 2013-01-16 [PMID: 23325086] (B/N, Human)
• Fitzgerald AM, Benz C, Clark AF, Wordinger RJ. The Effects of Transforming Growth Factor-beta2 (TGF-beta2) on the Expression of Follistatin and Activin A in Normal and Glaucoma Human Trabecular Meshwork Cells and Tissues Invest Ophthalmol Vis Sci 2012-09-25 [PMID: 23010638]

Review for Activin A Antibody (NB110-61019) (1)

Average Rating: 4

(Based on 1 review)

We have 1 review tested in 1 species: Mouse.

reviewed by: Verified Customer IHC-P Mouse 07/23/2012

Summary

• Application: Immunohistochemistry-Paraffin
• Sample Tested: Mouse tissue section from colon
• Species: Mouse
• Lot: 7112012

Bioinformatics

• Gene Symbol: INHBA
• Entrez:
  • 3624(Human)
  • 16324(Mouse)
• Uniprot:
  • P08476()