Indian Hedgehog/Ihh Antibody (EP1192Y)

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Product Details

Summary
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Order Details


    • Catalog Number
      NB110-57122
    • Availability
      Product Discontinued

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Indian Hedgehog/Ihh Antibody (EP1192Y) Summary

Immunogen
A synthetic peptide corresponding to residues near the N-terminus of human IHH was used as an immunogen.
Isotype
IgG
Clonality
Monoclonal
Host
Rabbit
Gene
IHH
Purity
Tissue culture supernatant
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Paraffin 1:250-500
  • Immunoprecipitation 1:30
  • Western Blot 1:1000
Application Notes
This product is useful for: Western Blot, Immunohistochemistry-Paraffin, Immunoprecipitation. In Western blot this antibody detects a band at approximately 45kDa.
Theoretical MW
45 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Publications
Read Publications using
NB110-57122 in the following applications:

  • 1 publication
  • WB
    1 publication

Reactivity Notes

Reacts with: Mouse, Rat, Human

Packaging, Storage & Formulations

Storage
Store at -20C. Avoid freeze-thaw cycles.
Buffer
49% PBS, 0.05% BSA and 50% Glycerol
Preservative
0.01% Sodium Azide
Purity
Tissue culture supernatant

Notes

Produced using Abcam's RabMab® technology. RabMab® technology is covered by the following U.S. Patents, No. 5,675,063 and/or 7,429,487.

Alternate Names for Indian Hedgehog/Ihh Antibody (EP1192Y)

  • BDA1
  • BDA1Indian hedgehog homolog (Drosophila)
  • HHG2
  • HHG-2
  • Ihh
  • Indian hedgehog (Drosophila) homolog
  • Indian hedgehog homolog
  • indian hedgehog protein
  • Indian Hedgehog

Background

Hedgehog, WNT, FGF and BMP signaling pathways network together during embryogenesis, tissue regeneration, and carcinogenesis. Aberrant activation of Hedgehog signaling pathway leads to pathological consequences in a variety of human tumors, such as gastric cancer and pancreatic cancer (1). The hedgehog family of morphogens are regulators of cell proliferation, differentiation and cell-cell communication. These morphogens have been shown to have important roles in organogenesis, spermatogenesis, stem cell maintenance and oncogenesis. Indian hedgehog (IHH) has been shown to be expressed in the uterine epithelium under the control of the steroid hormone, progesterone (2). It has been shown that IHH, synthesized by prehypertrophic and hypertrophic chondrocytes, regulates the site of hypertrophic differentiation by signaling to the periarticular growth plate and also determines the site of bone collar formation in the adjacent perichondrium. By providing crucial local signals from prehypertrophic and hypertrophic chondrocytes to both chondrocytes and preosteoblasts, IHH couples chondrogenesis to osteogenesis in endochondral bone development (3).

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for Indian Hedgehog/Ihh Antibody (NB110-57122)(2)

We have publications tested in 1 confirmed species: Human.

We have publications tested in 2 applications: IHC-P, WB.


Filter By Application
IHC-P
(1)
WB
(1)
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Human
(1)
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Product General Protocols

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Video Protocols

WB Video Protocol

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Secondary Antibodies

 

Isotype Controls

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Bioinformatics

Gene Symbol IHH
Entrez
Uniprot