Western Blot: Importin-7 Antibody [NBP2-27150] - Analysis of IOP7 in MCF7 cell lysate in the 1) absence and 2) presence of immunizing peptide, and 3) RAW cell lysate using this antibody. Goat anti-rabbit Ig HRP ...read more
Immunohistochemistry-Paraffin: Importin-7 Antibody [NBP2-27150] - Analysis of IOP7 in formalin-fixed, paraffin-embedded mouse spleen tissue using an isotype control (top) and this antibody (bottom) at 5 ug/ml.
The amino acid sequence used as immunogen is 88% homologous in Xenopus. Primate reactivity reported in scientific literature (PMID: 24100013). Rat reactivity reported in scientific literature (PMID: 24184208).
Packaging, Storage & Formulations
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
PBS and 0.05% BSA
0.05% Sodium Azide
Protein A purified
Alternate Names for Importin-7 Antibody
RAN binding protein 7
Ran-binding protein 7
Importin-7 (IOP7) belongs to the Importin beta family and contains an importin N-terminal domain. It functions in nuclear protein import in association with importin-beta subunit kPNB1. It mediates autonomously the nuclear import of ribosomal proteins RPL23A, RPS7 and RPL5 and the nuclear import of H2A, H2B, H3 and H4 histones in vitro. Studies suggest it acts as a nuclear import receptor for the Glucocorticoid receptors. It also acts as a receptor for nuclear localization signals (NLS) and to promote translocation of import substrates through the nuclear pore complex (NPC) by an energy requiring, Ran-dependent mechanism. Reports indicate that in HIV-1 infection, IOP7 binds and mediates the nuclear import of HIV-1 Rev.
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
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