IMP2/IGF2BP2 Antibody

Product Discontinued

IMP2/IGF2BP2 Antibody Summary

• Immunogen: IMP-2 (NP_006539, 65 a.a. ~ 170 a.a) partial recombinant protein with GST tag.HGKIMEVDYSVSKKLRSRKIQIRNIPPHLQWEVLDGLLAQYGTVENVEQVNTDTETAVVNVTYATREEAKIAMEKLSGHQFENYSFKISYIPDEEVSSPSPPQRA
• Specificity: IMP-2 - IGF-II mRNA-binding protein 2
• Clonality: Polyclonal
• Host: Mouse
• Gene: IGF2BP2
• Purity: Unpurified

Applications/Dilutions

• Dilutions:
  • ELISA
  • Western Blot 1:500
• Application Notes: The quality control of this antibody is limited to Western blot on the immunizing protein. It has also been used for ELISA. Abnova's recommended working dilutions for western analysis are as follows: 1:500 dilution for ascites 1:1000 for purified Ig 1:500

Reactivity Notes

Human. Other species not tested.

Packaging, Storage & Formulations

• Storage: Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
• Buffer: Unpurified antisera so the specific antibody concentration is unknown. Contains 50% glycerol.
• Preservative: No Preservative
• Purity: Unpurified

Notes

This product is produced by and distributed for Abnova, a company based in Taiwan.

Alternate Names for IMP2/IGF2BP2 Antibody

• Hepatocellular carcinoma autoantigen p62
• IF2B2
• IGF2BP2
• IGF-II mRNA-binding protein 2
• IMP2
• IMP-2IGF2 mRNA-binding protein 2
• IMP2VICKZ family member 2
• insulin-like growth factor 2 mRNA binding protein 2
• insulin-like growth factor 2 mRNA-binding protein 2
• p62
• VICKZ2

Background

This gene encodes a member of the IGF-II mRNA-binding protein (IMP) family. The protein encoded by this gene contains several four KH domains and two RRM domains. It functions by binding to the 5' UTR of the insulin-like growth factor 2 (IGF2) mRNA and regulating IGF2 translation. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for IMP2/IGF2BP2 Antibody (H00010644-A01)(3)

Publications using H00010644-A01

• Polesskaya A, Degerny C, Pinna G et al. Genome-wide exploration of miRNA function in mammalian muscle cell differentiation. PLoS One. 2013-01-01 [PMID: 23991007] (Human)
• Rivera Vargas T, Boudoukha S, Simon A et al. Post-transcriptional regulation of cyclins D1, D3 and G1 and proliferation of human cancer cells depend on IMP-3 nuclear localization. Oncogene 2013-07-01 [PMID: 23812426]
• Boudoukha S, Cuvellier S, Polesskaya A. et al. Role of the RNA-binding protein IMP-2 in muscle cell motility. Mol Cell Biol 2010-10-18 [PMID: 20956565]

Bioinformatics

• Gene Symbol: IGF2BP2
• Entrez:
  • 10644(Human)
• OMIM:
  • 608289(Human)
• Uniprot:
  • NP_006539(Human)